Stepholidine: Difference between revisions
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|OtherNames=''l''-Stepholidine |
|OtherNames=''l''-Stepholidine |
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|Section1={{Chembox Identifiers |
|Section1={{Chembox Identifiers |
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| CASNo= |
| CASNo=16562-13-3 |
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| PubChem=5290 |
| PubChem=5290 |
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| SMILES=COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O |
| SMILES=COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O |
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Revision as of 23:19, 11 May 2009
-Stepholidine.svg)
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| Names | |
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| IUPAC name
(13aS)-3,9-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,10-diol
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| Other names
l-Stepholidine
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| Identifiers | |
3D model (JSmol)
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| MeSH | Stepholidine |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C19H21NO4 | |
| Molar mass | 327.374 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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(−)-Stepholidine is a naturally-occurring chemical compound found in the herb Stephania intermedia. Stepholidine is a dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.[1][2][3][4]
See also
References
- ^ Natesan S, Reckless GE, Barlow KB; et al. (2008). "The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist". Psychopharmacology (Berl.). 199 (2): 275–89. doi:10.1007/s00213-008-1172-1. PMID 18521575.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X (2007). "Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications". Curr. Med. Chem. 14 (28): 2996–3002. doi:10.2174/092986707782794050. PMID 18220736.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Jin GZ, Zhu ZT, Fu Y (2002). "(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions". Trends Pharmacol. Sci. 23 (1): 4–7. doi:10.1016/S0165-6147(00)01929-5. PMID 11804640.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Fu W, Shen J, Luo X; et al. (2007). "Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations". Biophys. J. 93 (5): 1431–41. doi:10.1529/biophysj.106.088500. PMID 17468175.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
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