Hans Clevers: Difference between revisions
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{{short description|Dutch molecular genetics and stem cell researcher}} |
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{{about|a Dutch molecular genetics and stem cell researcher|the purported horse mathematician|Clever Hans}} |
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{{Use dmy dates|date=September 2020}} |
{{Use dmy dates|date=September 2020}} |
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{{COI|date=October 2019}} |
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{{Infobox scientist |
{{Infobox scientist |
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| name = Hans Clevers |
| name = Hans Clevers |
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| image = Hans Clevers ( |
| image = Hans Clevers (2018).jpg |
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| caption = Clevers in |
| caption = Clevers in 2018 |
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| birth_name = Johannes Carolus Clevers<ref name="aaas">{{cite web |url=https://www.amacad.org/person/johannes-carolus-clevers |archive-url=https://web.archive.org/web/20220627014048/https://www.amacad.org/person/johannes-carolus-clevers |title=Johannes Carolus Clevers |publisher=[[American Academy of Arts and Sciences]] |archive-date=27 June 2022}}</ref> |
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| birth_date = {{birth date and age|1957|03|27|df=y}} |
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| birth_date = {{birth date and age|1957|03|27|df=y}}<ref name="wachter">{{cite web |title=2016 – Johannes C. Clevers |publisher=Ilse & Helmut Wachter Foundation, [[Medical University of Innsbruck]] |url=http://www.wachterstiftung.org/index.php/en/2016 |access-date=23 June 2022 |archive-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623022659/https://www.wachterstiftung.org/index.php/en/2016}}</ref><ref name="catalogus">{{cite web |title=Prof.dr. J.C. Clevers |url=https://profs.library.uu.nl/index.php/profrec/getprofdata/401/1/1/0 |publisher=[[Utrecht University]] |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623022659/https://profs.library.uu.nl/index.php/profrec/getprofdata/401/1/1/0 |archive-date=23 June 2022 |language=nl}}</ref><ref name="umc">{{cite web |title=Prof. dr. J.C. (Hans) Clevers |url=https://www.umcutrecht.nl/nl/ziekenhuis/zorgverleners/clevers-j-c |publisher=[[University Medical Center Utrecht]] |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623035053/https://www.umcutrecht.nl/nl/ziekenhuis/zorgverleners/clevers-j-c |archive-date=23 June 2022 |language=nl}}</ref> |
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| birth_place = [[Eindhoven]]<ref>[https://profs.library.uu.nl/index.php/profrec/getprofdata/401/1/1/0 Prof.dr. J.C. Clevers (1957 – )] at ''Catalogus Professorum Academiæ Rheno-Traiectinæ''.</ref> |
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| birth_place = [[Eindhoven]], [[Netherlands]]<ref name="wachter"/><ref name="catalogus"/> |
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| nationality = Dutch |
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| fields = [[Molecular genetics]] <br/> [[Cell biology]] |
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| nationality = Dutch |
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| workplaces = [[Roche]] <br/> {{ill|Prinses Máxima Centrum|lt=Princess Máxima Center|nl}} <br/> [[University Medical Center Utrecht]] <br/> [[Royal Netherlands Academy of Arts and Sciences#Research institutes|Hubrecht Institute for Developmental Biology and Stem Cell Research]] <br/>[[Utrecht University]] <br/> [[Dana–Farber Cancer Institute]] |
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| fields = Molecular genetics and Cell biology |
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| education = |
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| workplaces = Hubrecht Institute for Developmental Biology and Stem Cell Research – Utrecht University – UMC Utrecht – The Princess Maxima Center for pediatric oncology |
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| alma_mater = [[University of Utrecht]] |
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| patrons = |
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| thesis_title = Early events in lymphocyte activation |
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| education = University of Utrecht |
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| thesis_url = https://utrechtuniversity.on.worldcat.org/oclc/63836041 |
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| thesis_year = 1985 |
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| doctoral_advisor = [[Rudy Ballieux]]<ref name="cellstemcell">{{cite journal |title=Mentoring the Next Generation: Hans Clevers |journal=[[Cell Stem Cell]] |date=2018 |volume=23 |issue=6 |pages=784–786 |doi=10.1016/j.stem.2018.11.004 |s2cid=239579550 |doi-access=free }}</ref> |
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| doctoral_advisor = [[Rudy Ballieux]] |
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| known_for = [[Organoid]] generation and application |
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| awards = [[Louis-Jeantet Prize for Medicine]] |
| awards = [[Louis-Jeantet Prize for Medicine]] <br/> [[Breakthrough Prize in Life Sciences]] <br/> [[Heineken Prizes|Dr A. H. Heineken Prize for Medicine]] <br/> [[Körber European Science Prize]] |
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| spouse = Eefke Petersen<ref>{{cite magazine |last=Clevers |first=Hans |date=1 October 2021 |title=The development of organoids for cancer research: an ode to the scientific method |url=https://cancerworld.net/the-development-of-organoids-for-cancer-research-an-ode-to-the-scientific-method/ |magazine=Cancer World |location= |access-date=29 June 2022 |archive-url=https://web.archive.org/web/20220629083458/https://cancerworld.net/the-development-of-organoids-for-cancer-research-an-ode-to-the-scientific-method/ |archive-date=29 June 2022}}</ref> |
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| children = 2<ref name="wachter"/> |
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| website = https://www.hubrecht.eu/research-groups/clevers-group/ |
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'''Johannes (Hans) Carolus Clevers''' (born 27 March 1957)<ref name="wachter"/><ref name="catalogus"/> is a Dutch [[Molecular genetics|molecular geneticist]], [[Cell biology|cell biologist]] and [[stem cell]] researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the [[Switzerland|Swiss]] healthcare company [[Roche]] in 2022.<ref name="cv">{{cite web |title=CURRICULUM VITAE |url=https://www.hubrecht.eu/app/uploads/2015/08/CV-Hans-Clevers-April-2022.pdf |publisher=[[University of Utrecht]] |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623022211/https://www.hubrecht.eu/app/uploads/2015/08/CV-Hans-Clevers-April-2022.pdf |archive-date=23 June 2022}}</ref><ref name="roche">{{cite web |title=Prof. Dr. Hans Clevers |url=https://www.roche.com/about/leadership/hans-clevers |publisher=[[Roche]] |access-date=23 June 2022 |archive-url=https://archive.today/20220623032533/https://www.roche.com/about/leadership/hans-clevers |archive-date=23 June 2022}}</ref> Previously, he headed a research group at the [[Royal Netherlands Academy of Arts and Sciences#Research institutes|Hubrecht Institute for Developmental Biology and Stem Cell Research]]<ref name="hubrecht">{{cite web |title=Clevers: Adult stem cell-based organoids |url=https://www.hubrecht.eu/research-groups/clevers-group/ |publisher=University of Utrecht |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623022110/https://www.hubrecht.eu/research-groups/clevers-group/ |archive-date=23 June 2022}}</ref> and at the {{ill|Prinses Máxima Centrum|lt=Princess Máxima Center|nl}};<ref name="princess">{{cite web |title=Clevers group |url=https://research.prinsesmaximacentrum.nl/en/research-groups/clevers-group |publisher={{ill|Prinses Máxima Centrum|lt=Princess Máxima Center|nl}} |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623032209/https://research.prinsesmaximacentrum.nl/en/research-groups/clevers-group |archive-date=23 June 2022}}</ref> he remained as an advisor and guest scientist or visiting researcher to both groups.<ref name="cv"/> He is also a [[Professor]] in Molecular Genetics at the [[University of Utrecht]].<ref name="roche"/> |
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'''Johannes Carolus (Hans) Clevers''' (born 27 March 1957)<ref name="Wachter">{{cite web | title=2016 – Johannes C. Clevers | website=Ilse & Helmut Wachter Stiftung | url=http://www.wachterstiftung.org/index.php/en/2016 | access-date=18 September 2020}}</ref> is Principal Investigator at the [[Hubrecht Institute]] for Developmental Biology and Stem Cell Research (KNAW) and the Princess Máxima Center for Pediatric Oncology, Professor at [[Utrecht University]] and [[Oncode]] Investigator. Clevers was the first to identify living stem cells in the intestine and is one of the world's leading researchers on adult stem cells, their role in cancer and their potential for regenerative therapy.<ref name="irb">{{cite web|url=http://www.irbbarcelona.org/index.php/en/news/irb-news/corporative/hans-cleversevery-day-new-research-is-showing-us-that-many-types-of-cancers-are-fed-by-tumour-stem-cells|title=Hans Clevers: "Every day new research is showing us that many types of cancers are fed by tumour stem cells"|work=IRB Barcelona}}</ref> |
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By culturing living stem cells from the intestinal tract, he developed the first organoids: 3D-mini-organs that behave cellularly and molecularly like the organ the stem cell derived from. Organoids can now be grown from a large number of tissues and are increasingly being used to study the physiology and pathology of many human organs and to develop personalized treatments and new drugs. |
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== Early life and education== |
== Early life and education== |
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Hans Clevers was born in [[Eindhoven]], the [[Netherlands]] in 1957.<ref name="umc"/> He began studying [[biology]] at the [[University of Utrecht]] in 1975, but also started taking [[medicine]] in 1978,<ref name="cv"/> in part due to his interest and in part because his friends and brothers were in the medical profession.<ref name="dmm">{{cite journal |title=A gutsy approach to stem cells and signalling: an interview with Hans Clevers |journal=[[Disease Models & Mechanisms]] |date=2013 |volume=6 |issue=5 |pages=1053–1056 |doi=10.1242/dmm.013367 |pmid=24046385 |url=https://journals.biologists.com/dmm/article/6/5/1053/3555/A-gutsy-approach-to-stem-cells-and-signalling-an |access-date=23 June 2022 |pmc=3759325 |archive-url=https://web.archive.org/web/20220623041806/https://journals.biologists.com/dmm/article/6/5/1053/3555/A-gutsy-approach-to-stem-cells-and-signalling-an |archive-date=23 June 2022|last1=Clevers |first1=H. }}</ref> He spent 1 year in [[Nairobi]], [[Kenya]], and half a year at the [[National Institutes of Health]] in [[Bethesda, Maryland|Bethesda]], [[United States]], for biology rotations.<ref name="dmm"/><ref>{{cite web |title=Hans Clevers on Becoming a Scientist |publisher=[[Cold Spring Harbor Laboratory]] |url=http://library.cshl.edu/oralhistory/interview/scientific-experience/becoming-scientist/hans-clevers-becoming-scientist/ |archive-date=23 June 2022 |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623034720/http://library.cshl.edu/oralhistory/interview/scientific-experience/becoming-scientist/hans-clevers-becoming-scientist/}}</ref> He received a [[Doctorandus|''Doctoraal'']] (equivalent to an [[Master of Science|MSc]]) in Biology in 1982 and an ''Artsexamen'' (equivalent to an [[Doctor of Medicine|MD]]) in 1984. Mostly because of his research background, Clevers was selected for a training position in [[paediatrics]], and then went to pursue a [[Doctor of Philosophy|PhD]] in 1985, under the supervision of [[Rudy Ballieux]].<ref name="cellstemcell"/><ref>{{cite news |first1=Roos |last1=Menkhorst |url=http://www.roosmenkhorst.nl/interviews/ik-leerde-het-belang-van-vertrouwen-in-mezelf/ |title=Ik leerde het belang van vertrouwen in mezelf |language=nl |work=[[Trouw]] |date=22 June 2013 |access-date=23 June 2022 |archive-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623034720/http://www.roosmenkhorst.nl/interviews/ik-leerde-het-belang-van-vertrouwen-in-mezelf/}}</ref><ref>{{cite web |url=https://breakthroughprize.org/Laureates/2/L29 |title=Hans Clevers |publisher=[[Breakthrough Prize in Life Sciences]] |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623033308/https://breakthroughprize.org/Laureates/2/L29 |archive-date=23 June 2022}}</ref> He obtained his PhD 1 year later.<ref name="cv"/><ref name="dmm"/> |
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Hans Clevers began studying biology at the University of Utrecht in 1975, then began studying medicine as well. He spent part of his seven years of biological study in [[Nairobi, Kenya]], and also, in his words, “did some rotations” at the National Institutes of Health in Bethesda. He received an M.Sc. in Biology in 1982, an M.D. in 1984 and a Ph.D. in 1985. For his Ph.D. he studied under [[Rudy Ballieux]].<ref>{{cite news|author=Roos Menkhorst |url=http://www.trouw.nl/tr/nl/5009/Archief/article/detail/3463468/2013/06/22/Ik-leerde-het-belang-van-vertrouwen-in-mezelf.dhtml |title=Ik leerde het belang van vertrouwen in mezelf |language=nl |newspaper=[[Trouw]] |date=22 June 2013 |access-date=20 February 2016}}</ref><ref>{{cite web|url=https://breakthroughprize.org/Laureates/2/L29 |title=Laureates: Hans Clevers |publisher=Breakthrough Prize |access-date=20 February 2016}}</ref> From 1986 to 1989 he did postdoctoral work under the direction of [[Cox Terhorst]] at the Dana-Farber Cancer Institute at Harvard University. After his stay at Harvard, he returned to the Netherlands to start his own research group at the department of Clinical immunology of the UMC Utrecht. Describing his path to his career as a medical researcher, Clevers said the following: “There was a bit of an awkward route. I actually studied biology first, and then took up medical school at about the same time....Did two separate studies, graduated from both, was going to be a pediatrician, then decided to spend a year in science, liked it so much more that I realized I didn’t – I shouldn’t become a real doctor. I was not good with – I liked patients, but I was a little bit impatient with them. I then decided to go for a post-doc at Boston to Dana Farber, where I really learned the trade.”<ref name="cshl">{{cite web| title =Hans Clevers on Becoming a Scientist | work =Oral History Collection| url =http://library.cshl.edu/oralhistory/interview/scientific-experience/becoming-scientist/hans-clevers-becoming-scientist/}}</ref><ref name="hubr">{{cite web| title =Hans Clevers| work =Hubrecht Institute| url =http://www.hubrecht.eu/research/clevers/leader.html| access-date =15 March 2012| archive-url =https://web.archive.org/web/20111231063359/http://www.hubrecht.eu/research/clevers/leader.html| archive-date =31 December 2011| url-status =dead}}</ref><ref name="umc">{{cite web| title =prof.dr. Hans Clevers| work =UMC Utrecht | url =http://www.umcutrecht.nl/zorg/patienten/zorgverleners/C/clevers/}}</ref> |
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==Career== |
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In 1991 Clevers became a professor of [[immunology]] at the University Medical Center in Utrecht. Since 2002 he has been a professor of [[molecular genetics]] at UMC Utrecht and Utrecht University. From 2002 to 2012 he was director of the [https://www.hubrecht.eu Hubrecht Institute] for Developmental Biology and Stem-Cell Research at the [[Royal Netherlands Academy of Arts and Sciences]]. |
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In 2008 and 2015 he received ERC Advanced Investigator Grants. In 2013 he was awarded the $3 million [[Breakthrough Prize in Life Sciences]] for his work. In March 2012, Clevers, who since 2000 had been a member of the Royal Netherlands Academy of Arts and Sciences, was elected its president, succeeding Robbert Dijkgraaf. In connection with his election to this position, he resigned as director from the Hubrecht Institute but kept his research lab there.<ref name=cshl/><ref name=hubr/><ref name=umc/><ref name=knaw>{{cite web| title =Het spijt ons, maar deze pagina bestaat niet| work =KNAW| url =http://www.knaw.nl/Pages/DEF/33/351.bGFuZz1FTkc.html| url-status =dead| archive-url =https://web.archive.org/web/20130806101828/http://www.knaw.nl/Pages/DEF/33/351.bGFuZz1FTkc.html| archive-date =6 August 2013}}</ref><ref name=neth>{{cite web| title =Heineken Prize and presidency for Hans Clevers| work =Netherlands Proteomics Centre| url =http://www.netherlandsproteomicscentre.nl/npc/publications/npc-news/clevers-new-president-knaw.html }}</ref> From 2012–2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). From 2015–2019 he was director Research of the Princess Maxima Center for paediatric oncology, located on the Utrecht Science Park close to the Hubrecht where he maintains his lab. Presently, Clevers leads research groups, at the Hubrecht Institute as well as at the Princess Maxima Center. |
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{{Commons category}} |
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==Research== |
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== Career == |
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===Highlights of research=== |
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After his [[Doctor of Philosophy|PhD]], Clevers went to the [[Dana–Farber Cancer Institute]] as a [[postdoctoral researcher]] at Cox Terhorst's group.<ref name="roche"/><ref name="dmm"/><ref name="hubr">{{cite web |title=Hans Clevers |publisher=Hubrecht Institute for Developmental Biology and Stem Cell Research |url=http://www.hubrecht.eu/research/clevers/leader.html |access-date=15 March 2012 |archive-url=https://web.archive.org/web/20111231063359/http://www.hubrecht.eu/research/clevers/leader.html |archive-date=31 December 2011}}</ref><ref>{{cite web |title=Distinguished Lecture: Hans Clevers - "Gut Stem Cells, Organoids, and Precision Medicine |url=https://precisionmedicine.columbia.edu/events/distinguished-lecture-hans-clevers-gut-stem-cells-organoids-and-precision-medicine |publisher=[[Columbia University]] |access-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623070153/https://precisionmedicine.columbia.edu/events/distinguished-lecture-hans-clevers-gut-stem-cells-organoids-and-precision-medicine |archive-date=23 June 2022}}</ref> In 1989, he returned to the [[Netherlands]], joining his ''[[alma mater]]'', the [[University of Utrecht]], as an [[assistant professor]] at the Department of Clinical Immunology.<ref name="roche"/> |
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To summarise his scientific highlights, Hans Clevers identified the crucial downstream component of the Wnt signaling cascade, TCF, and the mechanism by which Wnt signals activate specific TCF target genes. With these insights and in a collaboration with Bert Vogelstein, he proposed that in APC-deficient colon cancer, it is the inappropriate activation of the Wnt pathway that transforms cells. He was the first to link Wnt signaling with adult stem cell biology, when he showed that TCF4 gene disruption leads to the abolition of crypt stem cell compartments of the gut. He went on to show that the Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological crypt stem cell program. Clevers then described the Wnt target Lgr5 as a marker for adult stem cells and wth this, discovered the stem cells of intestinal crypts. By the creation of several ingenious Lgr5-based transgenic mice, he established the intestinal crypt as one of the pre-eminent models to visualize and study adult stem cells in mammals. He described several counter-intuitive characteristics for crypt stem cells: Lgr5 stem cells are abundant, they cycle rapidly, they divide symmetrically, and utilize their Paneth cell-daughters as their niche. He then identified the Wnt signal-enhancing Rspondins as ligands of Lgr5, and exploited the Rspondin/Lgr5 axis to develop a 3D [[organoid]] culture system for indefinite expansion of normal intestinal epithelium starting from a single adult Lgr5 stem cell. Similar results were then reported by him for multiple additional human and mouse tissues. This has opened ways to replace animal experimentation to generate disease models directly from patients as well as avenues for regenerative medicine. |
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In 1991, Clevers became a [[professor]] and the chair of the Department of [[Immunology]] at the University of Utrecht.<ref name="roche"/> He moved to the [[University Medical Center Utrecht]] in 2002 as a professor in [[molecular genetics]], and started his lab at the [[Royal Netherlands Academy of Arts and Sciences#Research institutes|Hubrecht Institute for Developmental Biology and Stem Cell Research]] (Hubrecht Institute).<ref name="cv"/> At the same time, he took up the position of Director of the Hubrecht Institute.<ref name="roche"/> |
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Asked in a 2008 interview what had been the highlights of his research up to that point, Clevers said there would probably be three. There was a first one, when I just started my lab, within the first few months we cloned the gene that they call [[TCF1]], T-cell factor 1, I used to be a T-cell embryologist when we first started out. And that paper was published in ''[[EMBO]]'' in ’91. So in that paper we described cloning of this vector, which at that time maybe on the world scale was not great but for my own lab to clone this gene was my first thing I ever did alone. This gene then in ’96 we found to be the crucial missing component of what’s called the Wnt signaling pathway.<ref name=cshl/> |
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In March 2012, Clevers was elected the president of the Royal Netherlands Academy of Arts and Sciences, succeeding [[Robbert Dijkgraaf]].<ref>{{cite news |last1=van Aartsen |first1=Carina |title=Hans Clevers volgt KNAW-president Robbert Dijkgraaf op |url=https://www.zorgvisie.nl/hans-clevers-volgt-knaw-president-robbert-dijkgraaf-op-zvs013602w/ |access-date=23 June 2022 |work=Zorgvisie |date=26 March 2012 |archive-url=https://web.archive.org/web/20220623072658/https://www.zorgvisie.nl/hans-clevers-volgt-knaw-president-robbert-dijkgraaf-op-zvs013602w/ |archive-date=23 June 2022 |language=nl}}</ref><ref>{{cite web |title=President: Hans Clevers |publisher=[[Royal Netherlands Academy of Arts and Sciences]] |url=http://knaw.nl/Pages/DEF/33/351.bGFuZz1FTkc.html |archive-url=https://web.archive.org/web/20130201064042/http://knaw.nl/Pages/DEF/33/351.bGFuZz1FTkc.html |archive-date=1 February 2013}}</ref> His term concluded in 2015, and he started another lab at the {{ill|Prinses Máxima Centrum|lt=Princess Máxima Center|nl}},<ref name="roche"/> focusing on [[childhood cancer]],<ref name="princess"/> and became the Director Research and Chief Scientific Officer there until 2019.<ref name="roche"/> |
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[[File:Chemist Hans Clevers replaces worn-down body parts with organoids created outside the body-VPRO-The Mind of the Universe.ogv|thumb|left|Hans Clevers whilst being interviewed for the Dutch TV-show The Mind of the Universe.]] |
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Clevers and his team thus showed that “there is that this TCF transcription factor, there is a small family of them, they occur in every animal on the planet, they are the end point of the signal transcription cascade, and they control virtually every decision in a developing animal. When we realized this we started changing our model systems, we used to work on lymphocytes, and we changed it, first to frogs and flies, drosophila, where the Wnt pathway had been studied by many other people that way we could use assays of those people. We then realized that in mammals Wnt signaling...was not only important in embryos but also crucial in adults, which is novel. And we switched to the gut, we found that one of our knockouts, the TCF4 knockout, one of the four members of that family had no stem cells in the gut. And this is the first link in the literature, this was also a ’97 paper in Nature Genetics, between Wnt signaling and stem cells in adults. And in that same year we found in a collaboration with Bert Vogelstein that colon cancer comes about by the disregulation of TCF4, and those two phenomena are really linked. So stem cells need TCF4, cancers disregulate TCF4 by mutating a gene upstream in that pathway called APC. After this Clevers's team continued to work on the intestine. |
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Clevers left University Medical Center Utrecht and was appointed [[Professor]] in Molecular Genetics at the [[University of Utrecht]] in 2020.<ref name="cv"/> |
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==Other activities== |
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===Corporate boards=== |
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Clevers is inventor on multiple patents and was involved in the establishment of the biotech firm Ubisys, which, with Ton Logtenberg as CEO, later merged with Introgene to become Crucell. In addition, his corporate roles include: |
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* [[Hoffmann-La Roche|Roche]], Non-Executive Member of the Board of Directors (since 2019)<ref>[https://www.roche.com/about/governance/board_of_directors.htm Board of Directors] [[Hoffmann-La Roche|Roche]].</ref> |
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* Decibel Therapeutics, Member of the Scientific Advisory Board (since 2016)<ref>[https://www.decibeltx.com/decibel-therapeutics-assembles-world-class-scientific-advisory-board/ Decibel Therapeutics Assembles World-Class Scientific Advisory Board] Decibel Therapeutics, press release of 1 November 2016.</ref> |
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* Surrozen, Co-Founder |
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In 2022, Clevers joined the [[Switzerland|Swiss]] healthcare company [[Roche]] as its Head of Pharma, Research and Early Development and a member of its Corporate Executive Committee.<ref>{{cite news |title=New challenge for Hans Clevers at Roche |url=https://www.hubrecht.eu/new-challenge-for-hans-clevers-at-roche/ |access-date=23 June 2022 |publisher=Hubrecht Institute for Developmental Biology and Stem Cell Research |date=1 February 2022 |archive-url=https://web.archive.org/web/20220623041238/https://www.hubrecht.eu/new-challenge-for-hans-clevers-at-roche/ |archive-date=23 June 2022}}</ref><ref>{{cite press release |title=Changes to the Roche Board of Directors and the Corporate Executive Committee |url=https://finance.yahoo.com/news/changes-roche-board-directors-corporate-170500257.html |publisher=Roche |location=[[Basel]] |date=1 February 2022 |access-date=23 June 2022 |archive-date=23 June 2022 |archive-url=https://web.archive.org/web/20220623034356/https://finance.yahoo.com/news/changes-roche-board-directors-corporate-170500257.html}}</ref> He remains an advisor and guest scientist or visiting researcher to his research groups at the Princess Máxima Center and Hubrecht Institute.<ref name="hubrecht"/><ref name="princess"/> |
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===Editorial boards=== |
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He is on the editorial board of several scientific journals, including ''[[Cell (journal)|Cell]]'', ''[[Cell Stem Cell]]'', ''[[Stem Cell Reports]]''. He is also an honorary professor at Central South University in Changsha, Hunan, China and honorary director of the organoid center of Fudan University, Shanghai. |
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Since 2017, Clevers is an investigator at the Oncode Institute in [[Utrecht]].<ref name="cv"/><ref>{{cite web |title=Hans Clevers Group |url=https://www.oncode.nl/research/groups/hans-clevers-group |publisher=Oncode Institute |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624072251/https://www.oncode.nl/research/groups/hans-clevers-group |archive-date=24 June 2022}}</ref> |
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===Non-profit organizations=== |
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* [[Francis Crick Institute]], Member of the Scientific Advisory Board |
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* Research Institute of Molecular Pathology (IMP), Member of the Scientific Advisory Board |
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Clevers has served at a number of scientific organizations, including on the board of directors of the [[American Association for Cancer Research]] (2013-2016),<ref>{{cite web |title=American Association for Cancer Research Councilors and Directors |url=https://www.aacr.org/wp-content/uploads/2020/08/2020-07-30-AACR-Directors-and-Councilors.pdf |publisher=[[American Association for Cancer Research]] |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624075704/https://www.aacr.org/wp-content/uploads/2020/08/2020-07-30-AACR-Directors-and-Councilors.pdf |archive-date=24 June 2022}}</ref> and the Scientific Advisory Board of the [[Swiss Institute for Experimental Cancer Research]] at the [[École Polytechnique Fédérale de Lausanne]] (2005-2015),<ref name="roche"/> the [[Research Institute of Molecular Pathology]] in [[Vienna]] (2015-2021)<ref>{{cite web |title=Former SAB Members |url=https://www.imp.ac.at/research/advisory-board/ |publisher=[[Research Institute of Molecular Pathology]] |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624080114/https://www.imp.ac.at/research/advisory-board/ |archive-date=24 June 2022}}</ref> and the [[Francis Crick Institute]] in [[London]].<ref>{{cite web |title=Hans Clevers |url=https://www.crick.ac.uk/about-us/leadership-structure/board/scientific-advisory-board/hans-clevers |publisher=[[Francis Crick Institute]] |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624080941/https://www.crick.ac.uk/about-us/leadership-structure/board/scientific-advisory-board/hans-clevers |archive-date=24 June 2022}}</ref> He is currently on the advisory board of various [[scientific journal]]s, including ''[[The EMBO Journal]]'',<ref>{{cite web |title=Advisory Board Biographies |url=https://www.embopress.org/page/journal/14602075/boardbios |publisher=[[The EMBO Journal]] |access-date=24 June 2022 |archive-url=https://archive.today/20220627031741/https://www.embopress.org/page/journal/14602075/boardbios |archive-date=27 June 2022}}</ref> ''[[Disease Models & Mechanisms]]'',<ref>{{cite web |title=Editors and Board |url=https://journals.biologists.com/dmm/pages/edboard |publisher=[[Disease Models & Mechanisms]] |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624072638/https://journals.biologists.com/dmm/pages/edboard |archive-date=24 June 2022}}</ref> ''[[Cell (journal)|Cell]]'',<ref>{{cite web |title=Staff and advisory board |url=https://www.cell.com/cell/editorial-board |publisher=[[Cell (journal)|Cell]] |access-date=24 June 2022 |archive-url=https://archive.today/20220627032010/https://www.cell.com/cell/editorial-board |archive-date=27 June 2022}}</ref> ''[[Cell Stem Cell]]''<ref>{{cite web |title=Advisory board |url=https://www.cell.com/cell-stem-cell/advisory-board |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624073322/https://www.cell.com/cell-stem-cell/advisory-board |publisher=[[Cell Stem Cell]] |archive-date=24 June 2022}}</ref> and ''[[EMBO Molecular Medicine]]''.<ref>{{cite web |title=Advisory Board Biographies |url=https://www.embopress.org/page/journal/17574684/boardbios |publisher=[[EMBO Molecular Medicine]] |access-date=24 June 2022 |archive-date=27 June 2022 |archive-url=https://archive.today/20220627032516/https://www.embopress.org/page/journal/17574684/boardbios}}</ref> From 2014 to 2022, he was also on the editorial committee of the ''[[Annual Review of Cancer Biology]]''.<ref name="cv"/> |
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==Honors and awards== |
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Clevers has been recognized for his research on a number of occasions: |
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Outside the academia, Clevers has been a scientific advisor to numerous [[biotechnology]] companies.<ref name="cv"/> He also co-founded [[California]]-based Surrozen<ref>{{cite web |title=Hans Clevers, MD, PhD |url=https://www.surrozen.com/team/hans-clevers |publisher=Surrozen |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624073719/https://www.surrozen.com/team/hans-clevers |archive-date=24 June 2022}}</ref> in 2016<ref>{{cite press release |title=Surrozen to Present at Cowen and Company 40th Annual Health Care Conference |url=https://www.surrozen.com/press-releases/surrozen-to-present-at-cowen-and-company-40th-annual-health-care-conference |access-date=24 June 2022 |work=Surrozen |date=2 March 2020 |archive-url=https://web.archive.org/web/20220624074629/https://www.surrozen.com/press-releases/surrozen-to-present-at-cowen-and-company-40th-annual-health-care-conference |archive-date=24 June 2022 |location=[[South San Francisco, California]]}}</ref> and [[Shanghai]]-based D1 Medical Technology<ref>{{cite web |title=创始团队 |url=http://www.d1med.com/h-col-111.html |publisher=D1 Medical Technology |access-date=24 June 2022 |archive-url=https://web.archive.org/web/20220624082243/http://www.d1med.com/h-col-111.html |archive-date=24 June 2022 |language=zh}}</ref> in 2019.<ref>{{cite news |title=丹望医疗完成数千万元天使轮融资,凯风创投领投 |url=https://finance.sina.com.cn/tech/2021-02-08/doc-ikftssap4842394.shtml |access-date=24 June 2022 |work=[[Sina Corporation|Sina]] |date=8 February 2021 |archive-url=https://web.archive.org/web/20220624083207/https://finance.sina.com.cn/tech/2021-02-08/doc-ikftssap4842394.shtml |archive-date=24 June 2022 |language=zh}}</ref> |
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*1999: Elected member of the [[European Molecular Biology Organization]] (EMBO)<ref>{{cite web|url=https://people.embo.org/profile/hans-c-clevers |title=Hans C. Clevers |publisher=European Molecular Biology Organization |access-date=16 May 2020}}</ref> |
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*2000: Elected member of the [[Royal Netherlands Academy of Arts and Sciences]]<ref>{{cite web|url=https://www.knaw.nl/en/members/members/3984 |archive-url=https://web.archive.org/web/20190816073032/https://www.knaw.nl/en/members/members/3984 |title=Hans Clevers |publisher=Royal Netherlands Academy of Arts and Sciences |archive-date=16 August 2019}}</ref> |
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*2000: Catharijne-prize for medical science<ref>{{cite web |title=Hans Clevers wins Keio Medical Science Prize |url=https://www.uu.nl/en/news/hans-clevers-wins-keio-medical-science-prize |publisher=Utrecht University |access-date=22 August 2021 |date=18 September 2019}}</ref> |
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*2001: Award from the European Society for Clinical Investigation |
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*2001: [[Spinoza Prize]] (Netherlands)<ref>{{cite web|url=http://www.nwo.nl/en/research-and-results/programmes/spinoza+prize/spinoza+laureates/overview+by+year/2001 |title=NWO Spinoza Prize 2001 |publisher=Netherlands Organisation for Scientific Research |date=5 September 2014 |access-date=30 January 2016}}</ref> |
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*2004: [[Louis-Jeantet Prize for Medicine]] (Switzerland)<ref name="Louis-Jeantet Prize" /><ref>{{cite web |title=Professor Hans CLEVERS Winner of the 2004 Louis-Jeantet Prize for medecine |url=https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2004-en/professeur-hans-clevers/ |access-date=22 August 2021}}</ref> |
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*2004: Named [[Chevalier of the Légion d'honneur]] (France) |
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*2005: Memorial Sloan-Kettering Katharine Berkan Judd Award (U.S.) |
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*2005: Science and Society Prize |
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*2006: Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research (Israel) |
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*2008: Josephine Nefkens Prize for Cancer Research from Erasmus MC Rotterdam (Netherlands) |
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*2008: [[Meyenburg Prize|Meyenburg Cancer Research Award (Germany)]] |
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*2009: Dutch Cancer Society Award |
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*2009: Elected member of [[Academia Europaea]]<ref>{{cite web|url=https://www.ae-info.org/ae/Member/Clevers_Hans |archive-url=https://web.archive.org/web/20190328131625/https://www.ae-info.org/ae/Member/Clevers_Hans |title=Hans Clevers |publisher=Academia Europaea |archive-date=28 March 2019}}</ref> |
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*2010: United European Gastroenterology Federation (UEGF) Research Prize |
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*2011: [[Ernst Jung Prize|Ernst Jung Prize for Medicine]] from the Jung Foundation for Science and Research (Germany)<ref>{{cite web|url=https://jung-stiftung.de/en/the-awards/ernst-jung-prize-for-medicine/laureates-1976-to-2018/ |archive-url=https://web.archive.org/web/20200331090401/https://jung-stiftung.de/en/the-awards/ernst-jung-prize-for-medicine/laureates-1976-to-2018/ |title=Laureates 1976 to 2018 |publisher=Ernst Jung Foundation |archive-date=31 March 2020}}</ref> |
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*2012: Elected international honorary member of the [[American Academy of Arts and Sciences]]<ref>{{cite web|url=https://www.amacad.org/person/hans-clevers |archive-url=https://web.archive.org/web/20200524142310/https://www.amacad.org/person/hans-clevers |title=Professor Dr. Hans Clevers |publisher=American Academy of Arts and Sciences |archive-date=24 May 2020}}</ref> |
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*2012: Léopold Griffuel Prize from Association pour la Recherche sur le Cancer (France)<ref>{{cite web |title=Prix Léopold Griffuel awarded to Hans Clevers |url=https://knaw.nl/en/news/news/hans-clevers-ontvangt-prestigieuze-franse-prijs |access-date=22 August 2021 |date=20 December 2011}}</ref> |
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*2012: Kolff Prize<ref>{{cite web |title=Kolff Prize 2011 awarded to Hans Clevers |url=https://www.knaw.nl/en/news/news/kolff-prijs-2011-voor-hans-clevers |access-date=22 August 2021 |date=4 October 2011}}</ref> |
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*2012: Knight of the [[Order of the Netherlands Lion]] (Netherlands)<ref>{{cite web|url=https://www.uu.nl/organisatie/koninklijke-onderscheidingen-2012 |archive-url=https://web.archive.org/web/20150509192405/https://www.uu.nl/organisatie/koninklijke-onderscheidingen-2012 |title=Koninklijke onderscheidingen 2012 |language=nl |publisher=Utrecht University |archive-date=9 May 2015}}</ref> |
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*2012: [[William Beaumont Prize]] of the American Gastroenterology Association |
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*2012: [[Heineken Prizes|Dr A.H. Heineken Prize for Medicine]] (Netherlands)<ref name="hubr" /><ref name="umc" /> |
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*2013: [[Breakthrough Prize in Life Sciences]]<ref>{{cite journal|title=A gutsy approach to stem cells and signalling: an interview with Hans Clevers|journal=Disease Models & Mechanisms|volume=6|issue=5|pages=1053–1056|doi=10.1242/dmm.013367|pmid=24046385|year=2013|doi-access=free|last1=Clevers|first1=H.|pmc=3759325}}</ref> |
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*2014: Elected foreign associate of the [[National Academy of Sciences]] (United States)<ref>{{cite web|url=http://www.nasonline.org/member-directory/members/20019189.html |archive-url=https://web.archive.org/web/20190324142102/http://www.nasonline.org/member-directory/members/20019189.html |title=Hans Clevers |publisher=National Academy of Sciences |archive-date=24 March 2019}}</ref> |
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*2014: Massachusetts General Hospital Award in Cancer Research |
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*2014: TEFAF Oncology Chair 2014 |
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*2014: Elected Fellow of the [[List of fellows of the AACR Academy|AACR Academy]]<ref>{{cite web|url=https://www.aacr.org/professionals/membership/aacr-academy/fellows/hans-clevers-md-phd/ |archive-url=https://web.archive.org/web/20200524144159/https://www.aacr.org/professionals/membership/aacr-academy/fellows/hans-clevers-md-phd/ |title=Hans Clevers, MD, PhD |publisher=American Association for Cancer Research |archive-date=24 May 2020}}</ref> |
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*2014: Struyvenberg European Society for Clinical Investigation (ESCI) medal |
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*2015: Elected foreign associate of the [[French Academy of Sciences]]<ref>{{cite web|url=https://www.academie-sciences.fr/en/Liste-des-membres-de-l-Academie-des-sciences-/-C/hans-clevers.html |archive-url=https://web.archive.org/web/20200524143402/https://www.academie-sciences.fr/en/Liste-des-membres-de-l-Academie-des-sciences-/-C/hans-clevers.html |title=Hans Clevers |language=fr |publisher=French Academy of Sciences |archive-date=24 May 2020}}</ref> |
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*2015: ISSCR-McEwen Award for Innovation |
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*2016: [[Pour le Mérite]] (Germany)<ref>{{cite web|url=http://www.orden-pourlemerite.de/mitglieder/hans-clevers |archive-url=https://web.archive.org/web/20200516155313/http://www.orden-pourlemerite.de/mitglieder/hans-clevers |title=Hans Clevers |language=de |publisher=orden-pourlemerite.de |url-status=live |archive-date=16 May 2020}}</ref> |
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*2016: Royal Netherlands Academy of Arts and Sciences Professor Prize<ref>{{cite web|url=https://www.knaw.nl/en/news/news/academy-professor-prize-awarded-to-ineke-sluiter-and-hans-clevers |title=Academy Professor Prize Awarded to Ineke Sluiter and Hans Clevers |publisher=Royal Netherlands Academy of Arts and Sciences |date=28 April 2016 |access-date=10 May 2016}}</ref> |
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*2016: Kazemi Prize of Royan Research Institute (Iran) |
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*2016: [[Körber European Science Prize]] |
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*2016: Swammerdam medaille (Het Genootschap ter Bevordering van Natuur-, Genees- en Heelkunde) |
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*2016: The Ilse & Helmut Wachter award<ref name="Wachter" /> |
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*2017: Princess Takamatsu Award of Merit (Japan) |
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*2017: Knight Commander's Cross of the [[Order of Merit of the Federal Republic of Germany]] (Großes Verdienstkreuz mit Stern) (Germany) |
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*2018: Academia Europaea Erasmus Medal (Spain) |
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*2019: Elected Foreign Member of the [[Royal Society]] (United Kingdom)<ref>{{cite web|url=https://royalsociety.org/people/hans-clevers-14084/ |archive-url=https://web.archive.org/web/20191023204815/https://royalsociety.org/people/hans-clevers-14084/ |title=Hans Clevers |publisher=The Royal Society |archive-date=23 October 2019}}</ref> |
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*2019: Honorary Fellow of the [[Royal Society of Edinburgh]]<ref>{{Cite web|url=https://www.rse.org.uk/fellow/hans-clevers/|title=Professor Johannes Carolus Clevers HonFRSE|date=15 March 2019|website=The Royal Society of Edinburgh|language=en-GB|access-date=15 March 2019}}</ref> (UK) |
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*2019: [[Keio Medical Science Prize]] of the Keio University (Japan) |
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*2019: Citation Laureate, Web of Science Group |
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*2021: Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research{{div col}}{{div col end}} |
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[[File:Chemist Hans Clevers replaces worn-down body parts with organoids created outside the body-VPRO-The Mind of the Universe.ogv|thumb|Hans Clevers interviewed for the Dutch [[television show]] The Mind of the Universe]] |
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==Publications== |
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== Research == |
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Clevers has more than 700 publications to his name and has been cited a total of more than 120,000 times. All his publications can be found on [https://www.ncbi.nlm.nih.gov/pubmed/?term=Clevers+H%5BAuthor%5D pubmed]. |
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Clevers's early career focused on the [[Wnt signaling pathway]].<ref>{{cite journal |last1=Sinha |first1=Gunjan |title=The organoid architect |journal=Science |date=2017 |volume=357 |issue=6353 |pages=746–749 |doi=10.1126/science.357.6353.746 |pmid=28839056 |url=https://www.science.org/doi/full/10.1126/science.357.6353.746 |access-date=28 June 2022 |archive-date=28 June 2022 |archive-url=https://archive.today/20220628041747/https://www.science.org/doi/full/10.1126/science.357.6353.746}}</ref> His group identified the [[TCF7|TCF1]] protein, a member of the [[TCF/LEF family|TCF gene family]] and a crucial downstream component of the Wnt signaling pathway, making it central in [[immune response]]s, [[Human embryonic development|embryonic development]] and tissue repair.<ref>{{cite journal |last1=van de Wetering |first1=Marc |last2=Oosterwegel |first2=Mariette |last3=Dooijes |first3=Dennis |last4=Clevers |first4=Hans |title=Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box |journal=The EMBO Journal |date=1991 |volume=10 |issue=1 |pages=123–132 |doi=10.1002/j.1460-2075.1991.tb07928.x |pmid=1989880 |pmc=452620 }}</ref> His interest in the [[gastrointestinal tract]] began with the discovery that another TCF family member, the [[TCF7L2|TCF4]] protein, is required in forming [[Intestinal gland|intestinal crypts]].<ref>{{cite journal |last1=Korinek |first1=Vladimir |last2=Barker |first2=Nick |last3=Moerer |first3=Petra |last4=van Donselaar |first4=Elly |last5=Huls |first5=Gerwin |last6=Peters |first6=Peter J. |last7=Clevers |first7=Hans |title=Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 |journal=[[Nature Genetics]] |date=1997 |volume=19 |issue=4 |pages=379–383 |doi=10.1038/1270 |pmid=9697701 |s2cid=1052683 |url=https://www.nature.com/articles/ng0898_379 |access-date=28 June 2022 |url-access=subscription}}</ref> Collaborating with [[Bert Vogelstein]], he found that in [[Colorectal cancer|colon cancer]] where the [[Adenomatous polyposis coli|APC]] gene is doubly mutated, TCF family members activate [[catenin beta-1]], which then enhances the expression of many genes that cause [[Carcinogenesis|cancer transformation]],<ref>{{cite journal |last1=Korinek |first1=Vladimir |last2=Barker |first2=Nick |last3=Morin |first3=Patrice J. |last4=van Wichen |first4=Dick |last5=de Weger |first5=Roel |last6=Kinzler |first6=Kenneth W. |last7=Vogelstein |first7=Bert |last8=Clevers |first8=Hans |title=Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC<sup>−/−</sup> Colon Carcinoma |journal=[[Science (journal)|Science]] |date=1997 |volume=275 |issue=5307 |pages=1784–1787 |doi=10.1126/science.275.5307.1784 |pmid=9065401 |s2cid=33935423 |url=https://www.science.org/doi/10.1126/science.275.5307.1784 |access-date=28 June 2022 |url-access=subscription}}</ref> connecting the Wnt signaling pathway with colon cancer. |
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In 2007, Clevers's group identified a marker for [[stem cell]]s of the [[Small intestine|small]] and [[large intestine]]s, [[LGR5]], itself also a target of the Wnt signaling pathway.<ref>{{cite journal |last1=Barker |first1=Nick |last2=van Es |first2=Johan H. |last3=Kuipers |first3=Jeroen |last4=Kujala |first4=Pekka |last5=van den Born |first5=Maaike |last6=Cozijnsen |first6=Miranda |last7=Haegebarth |first7=Andrea |last8=Korving |first8=Jeroen |last9=Begthel |first9=Harry |last10=Peters |first10=Peter J. |last11=Clevers |first11=Hans |title=Identification of stem cells in small intestine and colon by marker gene Lgr5 |journal=[[Nature (journal)|Nature]] |date=2007 |volume=449 |issue=7165 |pages=1003–1007 |doi=10.1038/nature06196 |pmid=17934449 |bibcode=2007Natur.449.1003B |s2cid=4349637 |url=https://www.nature.com/articles/nature06196 |access-date=23 June 2022 |url-access=subscription}}</ref> This led to his finding that LGR5 is a stem cell marker in other [[Organ (biology)|organs]] as well, including the [[stomach]]<ref name="stomachorganoid">{{cite journal |first1=Nick |last1=Barker |first2=Meritxell |last2=Huch |first3=Pekka |last3=Kujala |first4=Marc |last4=van de Wetering |first5=Hugo J. |last5=Snippert |first6=Johan H. |last6=van Es |first7=Toshiro |last7=Sato |first8=Daniel E. |last8=Stange |first9=Harry |last9=Begthel |first10=Maaike |last10=van den Born |first11=Esther |last11=Danenberg |first12=Stieneke |last12=van den Brink |first13=Jeroen |last13=Korving |first14=Arie |last14=Abo |first15=Peter J. |last15=Peters |first16=Nick |last16=Wright |first17=Richard |last17=Poulsom |first18=Hans |last18=Clevers |title=Lgr5<sup>+ve</sup> Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro |journal=Cell Stem Cell |date=2010 |volume=6 |issue=1 |pages=25–36 |doi=10.1016/j.stem.2009.11.013 |pmid=20085740 |doi-access=free }}</ref> and [[hair follicle]]s.<ref>{{cite journal |last1=Jaks |first1=Viljar |last2=Barker |first2=Nick |last3=Kasper |first3=Maria |last4=van Es |first4=Johan H |last5=Snippert |first5=Hugo J |last6=Clevers |first6=Hans |last7=Toftgård |first7=Rune |title=Lgr5 marks cycling, yet long-lived, hair follicle stem cells |journal=Nature Genetics |date=2008 |volume=40 |issue=11 |pages=1291–1299 |doi=10.1038/ng.239 |pmid=18849992 |s2cid=10883817 |access-date=23 June 2022 |url=https://www.nature.com/articles/ng.239 |url-access=subscription}}</ref> |
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Building on this discovery, in 2009, his group published a landmark paper, describing for the first time how [[organoid]]s, which are [[Three-dimensional space|3-dimensional]] ''[[in vitro]]'' structures that behave [[Anatomy|anatomically]] and [[Molecular biology|molecularly]] like the organ from which they are derived, were generated from [[adult stem cell]]s, creating organoids of the [[small intestine]].<ref>{{cite journal |last1=Sato |first1=Toshiro |last2=Vries |first2=Robert G. |last3=Snippert |first3=Hugo J. |last4=van de Wetering |first4=Marc |last5=Barker |first5=Nick |last6=Stange |first6=Daniel E. |last7=van Es |first7=Johan H. |last8=Abo |first8=Arie |last9=Kujala |first9=Pekka |last10=Peters |first10=Peter J. |last11=Clevers |first11=Hans |title=Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche |journal=Nature |date=2009 |volume=459 |issue=7244 |pages=262–265 |doi=10.1038/nature07935 |pmid=19329995 |bibcode=2009Natur.459..262S |s2cid=4373784 |url=https://www.nature.com/articles/nature07935 |access-date=23 June 2022 |url-access=subscription}}</ref> Clevers's group has applied this technology to [[Cell culture|culturing]] organoids from other organs, such as the stomach<ref name="stomachorganoid"/> and [[liver]],<ref>{{cite journal |first1=Meritxell |last1=Huch |first2=Craig |last2=Dorrell |first3=Sylvia F. |last3=Boj |first4=Johan H. |last4=van Es |first5=Marc |last5=van de Wetering |first6=Vivian S.W. |last6=Li |first7=Karien |last7=Hamer |first8=Nobuo |last8=Sasaki |first9=Milton J. |last9=Finegold |first10=Annelise |last10=Haft |first11=Markus |last11=Grompe |first12=Hans |last12=Clevers |title=In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration |journal=Nature |date=2013 |volume=494 |issue=7436 |pages=247–250 |doi=10.1038/nature11826 |pmid=23354049 |pmc=3634804 |bibcode=2013Natur.494..247H }}</ref> as well as from various [[cancer]] types, including cancer of the [[Breast cancer|breast]]<ref>{{cite journal |first1=Norman |last1=Sachs |first2=Joep |last2=de Ligt |first3=Oded |last3=Kopper |first4=Ewa |last4=Gogola |first5=Gergana |last5=Bounova |first6=Fleur |last6=Weeber |first7=Anjali |last7=Vanita Balgobind |first8=Karin |last8=Wind |first9=Ana |last9=Gracanin |first10=Harry |last10=Begthel |first11=Jeroen |last11=Korving |first12=Ruben |last12=van Boxtel |first13=Alexandra |last13=Alves Duarte |first14=Daphne |last14=Lelieveld |first15=Arne |last15=van Hoeck |first16=Robert Frans |last16=Ernst |first17=Francis |last17=Blokzijl |first18=Isaac Johannes |last18=Nijman |first19=Marlous |last19=Hoogstraat |first20=Marieke |last20=van de Ven |first21=David Anthony |last21=Egan |first22=Vittoria |last22=Zinzalla |first23=Jurgen |last23=Moll |first24=Sylvia |last24=Fernandez Boj |first25=Emile Eugene |last25=Voest |first26=Lodewyk |last26=Wessels |first27=Paul Joannes |last27=van Diest |first28=Sven |last28=Rottenberg |first29=Robert Gerhardus Jacob |last29=Vries |first30=Edwin |last30=Cuppen |first31=Hans |last31=Clevers |title=A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity |journal=[[Cell (journal)|Cell]] |date=2018 |volume=172 |issue=1–2 |pages=373–386 |doi=10.1016/j.cell.2017.11.010 |pmid=29224780 |s2cid=8951522 |doi-access=free }}</ref> and the [[Ovarian cancer|ovaries]].<ref>{{cite journal |first1=Oded |last1=Kopper |first2=Chris J. |last2=de Witte |first3=Kadi |last3=Lõhmussaar |first4=Jose Espejo |last4=Valle-Inclan |first5=Nizar |last5=Hami |first6=Lennart |last6=Kester |first7=Anjali |last7=Vanita Balgobind |first8=Jeroen |last8=Korving |first9=Natalie |last9=Proost |first10=Harry |last10=Begthel |first11=Lise M |last11=van Wijk |first12=Sonia |last12=Aristín Revilla |first13=Rebecca |last13=Theeuwsen |first14=Marieke |last14=van de Ven |first15=Markus J |last15=van Roosmalen |first16=Bas |last16=Ponsioen |first17=Victor W. H. |last17=Ho |first18=Benjamin G. |last18=Neel |first19=Tjalling |last19=Bosse |first20=Katja N. |last20=Gaarenstroom |first21=Harry |last21=Vrieling |first22=Maaike P. G. |last22=Vreeswijk |first23=Paul J. |last23=van Diest |first24=Petronella O. |last24=Witteveen |first25=Trudy |last25=Jonges |first26=Johannes L. |last26=Bos |first27=Alexander |last27=van Oudenaarden |first28=Ronald P. |last28=Zweemer |first29=Hugo J. G. |last29=Snippert |first30=Wigard P. |last30=Kloosterman 14, Hans Clevers |title=An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity |journal=[[Nature Medicine]] |date=2019 |volume=25 |issue=5 |pages=838–849 |doi=10.1038/s41591-019-0422-6 |pmid=31011202 |s2cid=126428230 |url=https://www.nature.com/articles/s41591-019-0422-6 |access-date=29 June 2022 |url-access=subscription}}</ref> This platform has since been applied in [[personalized medicine]], by generating organoids from specific patients to screen for drugs.<ref>{{cite journal |last1=Bartfeld |first1=Sina |title=Realizing the potential of organoids—an interview with Hans Clevers |journal=[[Journal of Molecular Medicine]] |date=2021 |volume=99 |issue=4 |pages=443–447 |doi=10.1007/s00109-020-02025-3 |pmid=33464358 |pmc=8026466 }}</ref><ref>{{cite journal |last1=Bender |first1=Eric |title=Q&A: Hans Clevers |journal=Nature |date=2015 |volume=521 |issue=7551 |page=S15 |doi=10.1038/521S15a |pmid=25970453 |bibcode=2015Natur.521S..15B |s2cid=4452738 |doi-access=free }}</ref> This is not limited to cancer but is applicable to other diseases as well (for example, cystic fibrosis).<ref>{{cite journal |last1=Saini |first1=Angela |title=Cystic Fibrosis Patients Benefit from Mini Guts |journal=Cell Stem Cell |date=2016 |volume=19 |issue=4 |pages=425–427 |doi=10.1016/j.stem.2016.09.001 |url=https://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30295-8.pdf |access-date=26 June 2022 |archive-date=25 June 2022 |archive-url=https://web.archive.org/web/20220625160459/https://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30295-8.pdf}}</ref> His current major research interest is in using organoids derived from adult stem cells to study the molecular mechanism of [[Tissue growth|tissue]] and [[Carcinogenesis|cancer development]]. |
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During the [[COVID-19 pandemic]], Clevers's group modelled the infection of [[SARS-CoV-2]] using [[lung]] organoids.<ref>{{cite journal |first1=Mart M |last1=Lamers |first2=Jelte |last2=van der Vaart |first3=Kèvin |last3=Knoops |first4=Samra |last4=Riesebosch |first5=Tim I |last5=Breugem |first6=Anna Z |last6=Mykytyn |first7=Joep |last7=Beumer |first8=Debby |last8=Schipper |first9=Karel |last9=Bezstarosti |first10=Charlotte D |last10=Koopman |first11=Nathalie |last11=Groen |first12=Raimond B G |last12=Ravelli |first13=Hans Q |last13=Duimel |first14=Jeroen A A |last14=Demmers |first15=Georges M G M |last15=Verjans |first16=Marion P G |last16=Koopmans |first17=Mauro J |last17=Muraro |first18=Peter J |last18=Peters |first19=Hans |last19=Clevers |first20=Bart L |last20=Haagmans |title=An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells |journal=The EMBO Journal |date=2021 |volume=40 |issue=5 |page=e105912 |doi=10.15252/embj.2020105912 |pmid=33283287 |pmc=7883112 }}</ref> |
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== Honours and awards == |
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* [[EMBO Membership|Member]] of the [[European Molecular Biology Organization]] (1999)<ref>{{cite web|url=https://people.embo.org/profile/hans-c-clevers |title=Hans C. Clevers |publisher=[[European Molecular Biology Organization]] |access-date=26 June 2022 |archive-date=26 June 2022 |archive-url=https://web.archive.org/web/20220626132717/https://people.embo.org/profile/hans-c-clevers}}</ref> |
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* [[Members of the Royal Netherlands Academy of Arts and Sciences|Member]] of the [[Royal Netherlands Academy of Arts and Sciences]] (2000)<ref>{{cite web |url=https://www.knaw.nl/en/members/members/3984 |archive-url=https://web.archive.org/web/20190816073032/https://www.knaw.nl/en/members/members/3984 |title=Hans Clevers |publisher=Royal Netherlands Academy of Arts and Sciences |archive-date=16 August 2019 |access-date=16 August 2019}}</ref> |
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* [[Spinoza Prize]] (2001)<ref>{{cite web |url=https://www.nwo.nl/en/research-and-results/programmes/spinoza+prize/spinoza+laureates/overview+by+year/2001 |title=NWO Spinoza Prize 2001 |archive-url=https://web.archive.org/web/20201031222948/https://www.nwo.nl/en/research-and-results/programmes/spinoza+prize/spinoza+laureates/overview+by+year/2001 |archive-date=31 October 2020 |publisher=[[Dutch Research Council]] |access-date=31 October 2020}}</ref> |
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* [[Louis-Jeantet Prize for Medicine]] (2004)<ref>{{cite web |url=https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2004-en/professeur-hans-clevers/ |title=Professor Hans CLEVERS |date=October 2017 |publisher=[[Louis-Jeantet Foundation]] |access-date=26 June 2022 |archive-date=26 June 2022 |archive-url=https://web.archive.org/web/20220626133933/https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2004-en/professeur-hans-clevers/}}</ref> |
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* [[Legion of Honour|Knight of the Legion of Honour]] (2005)<ref name="cv"/> |
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* [[Meyenburg Prize]] (2008)<ref>{{cite web |title=Die Preisträger |date=30 April 2005 |url=http://www.meyenburg-stiftung.de/2preis.htm |publisher=[[Meyenburg Prize|Meyenburg Foundation]] |access-date=26 June 2022 |archive-url=https://web.archive.org/web/20220404175758/http://meyenburg-stiftung.de/2preis.htm |archive-date=4 April 2022 |language=de}}</ref> |
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* Member of [[Academia Europaea]] (2009)<ref>{{cite web |url=https://www.ae-info.org/ae/Member/Clevers_Hans |archive-url=https://web.archive.org/web/20220626135235/https://www.ae-info.org/ae/Member/Clevers_Hans |title=Hans Clevers |publisher=[[Academia Europaea]] |archive-date=26 June 2022 |access-date=26 June 2022}}</ref> |
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* [[United European Gastroenterology|United European Gastroenterology Federation Research Prize]] (2010)<ref name="uegfrp2010">{{cite book |title=UEGW Barcelona 2010 : 18th United European Gastroenterology Week : Final Programme |date=2010 |publisher=[[United European Gastroenterology Federation]] (UEGF) |page=20 |url=https://www.yumpu.com/en/document/read/2082328/barcelona-2010-uegw-2010-united-european-gastroenterology |access-date=6 January 2024 |archive-url=https://web.archive.org/web/20240106083105/https://www.yumpu.com/en/document/read/2082328/barcelona-2010-uegw-2010-united-european-gastroenterology |archive-date=6 January 2024 |chapter=Awards & Grants : UEGF Research Prize : EUR 100.000 awarded for the most outstanding research programme}}</ref> |
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* [[Ernst Jung Prize|Ernst Jung Prize for Medicine]] (2011)<ref>{{cite web |url=https://jung-stiftung.de/en/the-awards/ernst-jung-prize-for-medicine/laureates-1976-to-2021/ |archive-url=https://web.archive.org/web/20220627013523/https://jung-stiftung.de/en/the-awards/ernst-jung-prize-for-medicine/laureates-1976-to-2021/ |title=Laureates 1976 to 2021 |publisher=[[Ernst Jung Prize|Ernst Jung Foundation]] |archive-date=27 June 2022 |access-date=27 June 2022}}</ref> |
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* International Honorary Member of the [[American Academy of Arts and Sciences]] (2012)<ref name="aaas"/> |
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* [[William Beaumont Prize]] (2012)<ref>{{cite web |title=William Beaumont Prize in Gastroenterology |url=https://gastro.org/membership/recognition-awards/william-beaumont-prize-in-gastroenterology/ |publisher=[[American Gastroenterological Association]] |access-date=27 June 2022 |archive-url=https://web.archive.org/web/20220627014255/https://gastro.org/membership/recognition-awards/william-beaumont-prize-in-gastroenterology/ |archive-date=27 June 2022}}</ref> |
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* [[Heineken Prizes|Dr A.H. Heineken Prize for Medicine]] (2012)<ref>{{cite web |title=Hans Clevers |url=https://www.heinekenprizes.org/portfolio-items/hans-clevers/?portfolioCats=12%2C13%2C14%2C15%2C16%2C17 |publisher=[[Heineken Prizes]] |access-date=27 June 2022 |archive-url=https://web.archive.org/web/20220627015520/https://www.heinekenprizes.org/portfolio-items/hans-clevers/?portfolioCats=12%2C13%2C14%2C15%2C16%2C17 |archive-date=27 June 2022}}</ref> |
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* Knight of the [[Order of the Netherlands Lion]] (2012)<ref>{{cite web |url=https://www.uu.nl/organisatie/koninklijke-onderscheidingen-2012 |archive-url=https://web.archive.org/web/20150509192405/https://www.uu.nl/organisatie/koninklijke-onderscheidingen-2012 |title=Koninklijke onderscheidingen 2012 |language=nl |publisher=Utrecht University |archive-date=9 May 2015 |access-date=9 May 2015}}</ref> |
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* Member of [[Koninklijke Hollandsche Maatschappij der Wetenschappen]] (2012)<ref>{{cite magazine |title=NIEUWE LEDEN |url=https://khmw.nl/wp-content/uploads/Jaarverslag-2012.pdf |archive-date=27 June 2022 |access-date=27 June 2022 |magazine=Jaarverslag 2012 |publisher=Koninklijke Hollandsche Maatschappij der Wetenschappen |archive-url=https://web.archive.org/web/20220627020324/https://khmw.nl/wp-content/uploads/Jaarverslag-2012.pdf}}</ref> |
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* [[Breakthrough Prize in Life Sciences]] (2013)<ref>{{cite web |title=Hans Clevers |url=https://breakthroughprize.org/Laureates/2/L29 |publisher=[[Breakthrough Prize in Life Sciences]] |access-date=16 April 2022 |archiveurl=https://web.archive.org/web/20220214084527/https://breakthroughprize.org/Laureates/2/L29 |archive-date=14 February 2022}}</ref> |
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* International Member of the [[National Academy of Sciences]] (2014)<ref>{{cite web|url=http://www.nasonline.org/member-directory/members/20019189.html |archive-url=https://web.archive.org/web/20220627020945/http://www.nasonline.org/member-directory/members/20019189.html |title=Hans Clevers |publisher=[[National Academy of Sciences]] |archive-date=27 June 2022 |access-date=27 June 2022}}</ref> |
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* Fellow of the [[American Association for Cancer Research]] Academy<ref>{{cite web |url=https://www.aacr.org/professionals/membership/aacr-academy/fellows/hans-clevers-md-phd/ |archive-url=https://web.archive.org/web/20220627021106/https://www.aacr.org/professionals/membership/aacr-academy/fellows/hans-clevers-md-phd/ |title=Hans Clevers, MD, PhD |publisher=American Association for Cancer Research |archive-date=27 June 2022 |access-date=27 June 2022}}</ref> |
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* Foreign Associate of the [[French Academy of Sciences]] (2015)<ref>{{cite web |url=https://www.academie-sciences.fr/en/Liste-des-membres-de-l-Academie-des-sciences-/-C/hans-clevers.html |archive-url=https://web.archive.org/web/20220628055503/https://www.academie-sciences.fr/en/Liste-des-membres-de-l-Academie-des-sciences-/-C/hans-clevers.html |title=Hans Clevers |language=fr |publisher=[[French Academy of Sciences]] |archive-date=28 June 2022 |access-date=27 June 2022}}</ref> |
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* [[Pour le Mérite]] (2016)<ref>{{cite web |url=https://www.orden-pourlemerite.de/mitglieder/hans-clevers |title=Hans Clevers |language=de |publisher=[[Pour le Mérite|Pour le Mérite für Wissenschaften und Künste]] |archive-date=28 June 2022 |archive-url=https://web.archive.org/web/20220628055635/https://www.orden-pourlemerite.de/mitglieder/hans-clevers |access-date=27 June 2022}}</ref><ref>{{cite web |title=Hans CLEVERS |url=https://www.orden-pourlemerite.de/sites/default/files/vita/hans-clevers-vita_0.pdf |publisher=Pour le Mérite für Wissenschaften und Künste |access-date=27 June 2022 |archive-url=https://web.archive.org/web/20220627023152/https://www.orden-pourlemerite.de/sites/default/files/vita/hans-clevers-vita_0.pdf |archive-date=27 June 2022}}</ref> |
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* [[Körber European Science Prize]] (2016)<ref>{{cite web |title=Hans Clevers (2016): Replacement organs from a petri dish |url=https://koerber-stiftung.de/en/projects/koerber-european-science-prize/previous-prizewinners/#s18440 |publisher=[[Körber Foundation]] |access-date=27 June 2022 |archive-url=https://web.archive.org/web/20220627023649/https://koerber-stiftung.de/en/projects/koerber-european-science-prize/previous-prizewinners/#s18440 |archive-date=27 June 2022}}</ref> |
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* Knight Commander's Cross of the [[Order of Merit of the Federal Republic of Germany]] (2018)<ref>{{cite news |title=German award for Hans Clevers |url=https://research.prinsesmaximacentrum.nl/en/news-events/news/german-award-for-hans-clevers |publisher=Princess Máxima Center |access-date=27 June 2022 |archive-url=https://web.archive.org/web/20220627025931/https://research.prinsesmaximacentrum.nl/en/news-events/news/german-award-for-hans-clevers|archive-date=27 June 2022 |date=2 March 2018}}</ref> |
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* [[Fellow of the Royal Society|Foreign Member]] of the [[Royal Society]] (2019)<ref>{{cite web |url=https://royalsociety.org/people/hans-clevers-14084/ |archive-url=https://web.archive.org/web/20220623022414/https://royalsociety.org/people/hans-clevers-14084/ |title=Hans Clevers |publisher=[[Royal Society]] |archive-date=23 June 2022 |access-date=23 June 2022}}</ref> |
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* [[Fellowship of the Royal Society of Edinburgh|Honorary Fellow]] of the [[Royal Society of Edinburgh]] (2019)<ref>{{cite web |url=https://www.rse.org.uk/fellow/hans-clevers/ |title=Professor Johannes Carolus Clevers ForMemRS, HonFRSE |publisher=[[Royal Society of Edinburgh]] |access-date=1 August 2020 |archive-date=1 August 2020 |archive-url=https://web.archive.org/web/20200801125007/https://www.rse.org.uk/fellow/hans-clevers/}}</ref> |
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* [[Keio Medical Science Prize]] (2019)<ref>{{cite web |title=Hans C. Clevers |url=https://www.ms-fund.keio.ac.jp/prize/024.html |publisher=[[Keio University]] |access-date=27 June 2022 |archive-url=https://web.archive.org/web/20200515052135/https://www.ms-fund.keio.ac.jp/prize/024.html |archive-date=15 May 2020 |language=ja}}</ref> |
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* [https://www.pezcoller.it/en/awards/the-pezcoller-foundation-%E2%80%93-aacr-international-award/2021---hans-clevers/ The Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research] (2021) |
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Revision as of 00:00, 29 March 2024
Hans Clevers | |
---|---|
![]() Clevers in 2018 | |
Born | Johannes Carolus Clevers[2] 27 March 1957[3][4][5] |
Nationality | Dutch |
Alma mater | University of Utrecht |
Known for | Organoid generation and application |
Spouse | Eefke Petersen[6] |
Children | 2[3] |
Awards | Louis-Jeantet Prize for Medicine Breakthrough Prize in Life Sciences Dr A. H. Heineken Prize for Medicine Körber European Science Prize |
Scientific career | |
Fields | Molecular genetics Cell biology |
Institutions | Roche Princess Máxima Center University Medical Center Utrecht Hubrecht Institute for Developmental Biology and Stem Cell Research Utrecht University Dana–Farber Cancer Institute |
Thesis | Early events in lymphocyte activation (1985) |
Doctoral advisor | Rudy Ballieux[1] |
Johannes (Hans) Carolus Clevers (born 27 March 1957)[3][4] is a Dutch molecular geneticist, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Swiss healthcare company Roche in 2022.[7][8] Previously, he headed a research group at the Hubrecht Institute for Developmental Biology and Stem Cell Research[9] and at the Princess Máxima Center ;[10] he remained as an advisor and guest scientist or visiting researcher to both groups.[7] He is also a Professor in Molecular Genetics at the University of Utrecht.[8]
Early life and education
Hans Clevers was born in Eindhoven, the Netherlands in 1957.[5] He began studying biology at the University of Utrecht in 1975, but also started taking medicine in 1978,[7] in part due to his interest and in part because his friends and brothers were in the medical profession.[11] He spent 1 year in Nairobi, Kenya, and half a year at the National Institutes of Health in Bethesda, United States, for biology rotations.[11][12] He received a Doctoraal (equivalent to an MSc) in Biology in 1982 and an Artsexamen (equivalent to an MD) in 1984. Mostly because of his research background, Clevers was selected for a training position in paediatrics, and then went to pursue a PhD in 1985, under the supervision of Rudy Ballieux.[1][13][14] He obtained his PhD 1 year later.[7][11]
![](http://upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png)
Career
After his PhD, Clevers went to the Dana–Farber Cancer Institute as a postdoctoral researcher at Cox Terhorst's group.[8][11][15][16] In 1989, he returned to the Netherlands, joining his alma mater, the University of Utrecht, as an assistant professor at the Department of Clinical Immunology.[8]
In 1991, Clevers became a professor and the chair of the Department of Immunology at the University of Utrecht.[8] He moved to the University Medical Center Utrecht in 2002 as a professor in molecular genetics, and started his lab at the Hubrecht Institute for Developmental Biology and Stem Cell Research (Hubrecht Institute).[7] At the same time, he took up the position of Director of the Hubrecht Institute.[8]
In March 2012, Clevers was elected the president of the Royal Netherlands Academy of Arts and Sciences, succeeding Robbert Dijkgraaf.[17][18] His term concluded in 2015, and he started another lab at the Princess Máxima Center ,[8] focusing on childhood cancer,[10] and became the Director Research and Chief Scientific Officer there until 2019.[8]
Clevers left University Medical Center Utrecht and was appointed Professor in Molecular Genetics at the University of Utrecht in 2020.[7]
In 2022, Clevers joined the Swiss healthcare company Roche as its Head of Pharma, Research and Early Development and a member of its Corporate Executive Committee.[19][20] He remains an advisor and guest scientist or visiting researcher to his research groups at the Princess Máxima Center and Hubrecht Institute.[9][10]
Since 2017, Clevers is an investigator at the Oncode Institute in Utrecht.[7][21]
Clevers has served at a number of scientific organizations, including on the board of directors of the American Association for Cancer Research (2013-2016),[22] and the Scientific Advisory Board of the Swiss Institute for Experimental Cancer Research at the École Polytechnique Fédérale de Lausanne (2005-2015),[8] the Research Institute of Molecular Pathology in Vienna (2015-2021)[23] and the Francis Crick Institute in London.[24] He is currently on the advisory board of various scientific journals, including The EMBO Journal,[25] Disease Models & Mechanisms,[26] Cell,[27] Cell Stem Cell[28] and EMBO Molecular Medicine.[29] From 2014 to 2022, he was also on the editorial committee of the Annual Review of Cancer Biology.[7]
Outside the academia, Clevers has been a scientific advisor to numerous biotechnology companies.[7] He also co-founded California-based Surrozen[30] in 2016[31] and Shanghai-based D1 Medical Technology[32] in 2019.[33]
Research
Clevers's early career focused on the Wnt signaling pathway.[34] His group identified the TCF1 protein, a member of the TCF gene family and a crucial downstream component of the Wnt signaling pathway, making it central in immune responses, embryonic development and tissue repair.[35] His interest in the gastrointestinal tract began with the discovery that another TCF family member, the TCF4 protein, is required in forming intestinal crypts.[36] Collaborating with Bert Vogelstein, he found that in colon cancer where the APC gene is doubly mutated, TCF family members activate catenin beta-1, which then enhances the expression of many genes that cause cancer transformation,[37] connecting the Wnt signaling pathway with colon cancer.
In 2007, Clevers's group identified a marker for stem cells of the small and large intestines, LGR5, itself also a target of the Wnt signaling pathway.[38] This led to his finding that LGR5 is a stem cell marker in other organs as well, including the stomach[39] and hair follicles.[40]
Building on this discovery, in 2009, his group published a landmark paper, describing for the first time how organoids, which are 3-dimensional in vitro structures that behave anatomically and molecularly like the organ from which they are derived, were generated from adult stem cells, creating organoids of the small intestine.[41] Clevers's group has applied this technology to culturing organoids from other organs, such as the stomach[39] and liver,[42] as well as from various cancer types, including cancer of the breast[43] and the ovaries.[44] This platform has since been applied in personalized medicine, by generating organoids from specific patients to screen for drugs.[45][46] This is not limited to cancer but is applicable to other diseases as well (for example, cystic fibrosis).[47] His current major research interest is in using organoids derived from adult stem cells to study the molecular mechanism of tissue and cancer development.
During the COVID-19 pandemic, Clevers's group modelled the infection of SARS-CoV-2 using lung organoids.[48]
Honours and awards
- Member of the European Molecular Biology Organization (1999)[49]
- Member of the Royal Netherlands Academy of Arts and Sciences (2000)[50]
- Spinoza Prize (2001)[51]
- Louis-Jeantet Prize for Medicine (2004)[52]
- Knight of the Legion of Honour (2005)[7]
- Meyenburg Prize (2008)[53]
- Member of Academia Europaea (2009)[54]
- United European Gastroenterology Federation Research Prize (2010)[55]
- Ernst Jung Prize for Medicine (2011)[56]
- International Honorary Member of the American Academy of Arts and Sciences (2012)[2]
- William Beaumont Prize (2012)[57]
- Dr A.H. Heineken Prize for Medicine (2012)[58]
- Knight of the Order of the Netherlands Lion (2012)[59]
- Member of Koninklijke Hollandsche Maatschappij der Wetenschappen (2012)[60]
- Breakthrough Prize in Life Sciences (2013)[61]
- International Member of the National Academy of Sciences (2014)[62]
- Fellow of the American Association for Cancer Research Academy[63]
- Foreign Associate of the French Academy of Sciences (2015)[64]
- Pour le Mérite (2016)[65][66]
- Körber European Science Prize (2016)[67]
- Knight Commander's Cross of the Order of Merit of the Federal Republic of Germany (2018)[68]
- Foreign Member of the Royal Society (2019)[69]
- Honorary Fellow of the Royal Society of Edinburgh (2019)[70]
- Keio Medical Science Prize (2019)[71]
- The Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research (2021)
References
- ^ a b "Mentoring the Next Generation: Hans Clevers". Cell Stem Cell. 23 (6): 784–786. 2018. doi:10.1016/j.stem.2018.11.004. S2CID 239579550.
- ^ a b "Johannes Carolus Clevers". American Academy of Arts and Sciences. Archived from the original on 27 June 2022.
- ^ a b c d "2016 – Johannes C. Clevers". Ilse & Helmut Wachter Foundation, Medical University of Innsbruck. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ a b c "Prof.dr. J.C. Clevers" (in Dutch). Utrecht University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ a b "Prof. dr. J.C. (Hans) Clevers" (in Dutch). University Medical Center Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ Clevers, Hans (1 October 2021). "The development of organoids for cancer research: an ode to the scientific method". Cancer World. Archived from the original on 29 June 2022. Retrieved 29 June 2022.
- ^ a b c d e f g h i j "CURRICULUM VITAE" (PDF). University of Utrecht. Archived from the original (PDF) on 23 June 2022. Retrieved 23 June 2022.
- ^ a b c d e f g h i "Prof. Dr. Hans Clevers". Roche. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ a b "Clevers: Adult stem cell-based organoids". University of Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ a b c "Clevers group". Princess Máxima Center . Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ a b c d Clevers, H. (2013). "A gutsy approach to stem cells and signalling: an interview with Hans Clevers". Disease Models & Mechanisms. 6 (5): 1053–1056. doi:10.1242/dmm.013367. PMC 3759325. PMID 24046385. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ "Hans Clevers on Becoming a Scientist". Cold Spring Harbor Laboratory. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ Menkhorst, Roos (22 June 2013). "Ik leerde het belang van vertrouwen in mezelf". Trouw (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ "Hans Clevers". Breakthrough Prize in Life Sciences. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ "Hans Clevers". Hubrecht Institute for Developmental Biology and Stem Cell Research. Archived from the original on 31 December 2011. Retrieved 15 March 2012.
- ^ "Distinguished Lecture: Hans Clevers - "Gut Stem Cells, Organoids, and Precision Medicine". Columbia University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ van Aartsen, Carina (26 March 2012). "Hans Clevers volgt KNAW-president Robbert Dijkgraaf op". Zorgvisie (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ "President: Hans Clevers". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 1 February 2013.
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- ^ "Changes to the Roche Board of Directors and the Corporate Executive Committee" (Press release). Basel: Roche. 1 February 2022. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
- ^ "Hans Clevers Group". Oncode Institute. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
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- ^ "Former SAB Members". Research Institute of Molecular Pathology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
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- ^ "Surrozen to Present at Cowen and Company 40th Annual Health Care Conference". Surrozen (Press release). South San Francisco, California. 2 March 2020. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
- ^ "创始团队" (in Chinese). D1 Medical Technology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
- ^ "丹望医疗完成数千万元天使轮融资,凯风创投领投". Sina (in Chinese). 8 February 2021. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
- ^ Sinha, Gunjan (2017). "The organoid architect". Science. 357 (6353): 746–749. doi:10.1126/science.357.6353.746. PMID 28839056. Archived from the original on 28 June 2022. Retrieved 28 June 2022.
- ^ van de Wetering, Marc; Oosterwegel, Mariette; Dooijes, Dennis; Clevers, Hans (1991). "Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box". The EMBO Journal. 10 (1): 123–132. doi:10.1002/j.1460-2075.1991.tb07928.x. PMC 452620. PMID 1989880.
- ^ Korinek, Vladimir; Barker, Nick; Moerer, Petra; van Donselaar, Elly; Huls, Gerwin; Peters, Peter J.; Clevers, Hans (1997). "Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4". Nature Genetics. 19 (4): 379–383. doi:10.1038/1270. PMID 9697701. S2CID 1052683. Retrieved 28 June 2022.
- ^ Korinek, Vladimir; Barker, Nick; Morin, Patrice J.; van Wichen, Dick; de Weger, Roel; Kinzler, Kenneth W.; Vogelstein, Bert; Clevers, Hans (1997). "Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma". Science. 275 (5307): 1784–1787. doi:10.1126/science.275.5307.1784. PMID 9065401. S2CID 33935423. Retrieved 28 June 2022.
- ^ Barker, Nick; van Es, Johan H.; Kuipers, Jeroen; Kujala, Pekka; van den Born, Maaike; Cozijnsen, Miranda; Haegebarth, Andrea; Korving, Jeroen; Begthel, Harry; Peters, Peter J.; Clevers, Hans (2007). "Identification of stem cells in small intestine and colon by marker gene Lgr5". Nature. 449 (7165): 1003–1007. Bibcode:2007Natur.449.1003B. doi:10.1038/nature06196. PMID 17934449. S2CID 4349637. Retrieved 23 June 2022.
- ^ a b Barker, Nick; Huch, Meritxell; Kujala, Pekka; van de Wetering, Marc; Snippert, Hugo J.; van Es, Johan H.; Sato, Toshiro; Stange, Daniel E.; Begthel, Harry; van den Born, Maaike; Danenberg, Esther; van den Brink, Stieneke; Korving, Jeroen; Abo, Arie; Peters, Peter J.; Wright, Nick; Poulsom, Richard; Clevers, Hans (2010). "Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro". Cell Stem Cell. 6 (1): 25–36. doi:10.1016/j.stem.2009.11.013. PMID 20085740.
- ^ Jaks, Viljar; Barker, Nick; Kasper, Maria; van Es, Johan H; Snippert, Hugo J; Clevers, Hans; Toftgård, Rune (2008). "Lgr5 marks cycling, yet long-lived, hair follicle stem cells". Nature Genetics. 40 (11): 1291–1299. doi:10.1038/ng.239. PMID 18849992. S2CID 10883817. Retrieved 23 June 2022.
- ^ Sato, Toshiro; Vries, Robert G.; Snippert, Hugo J.; van de Wetering, Marc; Barker, Nick; Stange, Daniel E.; van Es, Johan H.; Abo, Arie; Kujala, Pekka; Peters, Peter J.; Clevers, Hans (2009). "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche". Nature. 459 (7244): 262–265. Bibcode:2009Natur.459..262S. doi:10.1038/nature07935. PMID 19329995. S2CID 4373784. Retrieved 23 June 2022.
- ^ Huch, Meritxell; Dorrell, Craig; Boj, Sylvia F.; van Es, Johan H.; van de Wetering, Marc; Li, Vivian S.W.; Hamer, Karien; Sasaki, Nobuo; Finegold, Milton J.; Haft, Annelise; Grompe, Markus; Clevers, Hans (2013). "In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration". Nature. 494 (7436): 247–250. Bibcode:2013Natur.494..247H. doi:10.1038/nature11826. PMC 3634804. PMID 23354049.
- ^ Sachs, Norman; de Ligt, Joep; Kopper, Oded; Gogola, Ewa; Bounova, Gergana; Weeber, Fleur; Vanita Balgobind, Anjali; Wind, Karin; Gracanin, Ana; Begthel, Harry; Korving, Jeroen; van Boxtel, Ruben; Alves Duarte, Alexandra; Lelieveld, Daphne; van Hoeck, Arne; Ernst, Robert Frans; Blokzijl, Francis; Nijman, Isaac Johannes; Hoogstraat, Marlous; van de Ven, Marieke; Egan, David Anthony; Zinzalla, Vittoria; Moll, Jurgen; Fernandez Boj, Sylvia; Voest, Emile Eugene; Wessels, Lodewyk; van Diest, Paul Joannes; Rottenberg, Sven; Vries, Robert Gerhardus Jacob; Cuppen, Edwin; Clevers, Hans (2018). "A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity". Cell. 172 (1–2): 373–386. doi:10.1016/j.cell.2017.11.010. PMID 29224780. S2CID 8951522.
- ^ Kopper, Oded; de Witte, Chris J.; Lõhmussaar, Kadi; Valle-Inclan, Jose Espejo; Hami, Nizar; Kester, Lennart; Vanita Balgobind, Anjali; Korving, Jeroen; Proost, Natalie; Begthel, Harry; van Wijk, Lise M; Aristín Revilla, Sonia; Theeuwsen, Rebecca; van de Ven, Marieke; van Roosmalen, Markus J; Ponsioen, Bas; Ho, Victor W. H.; Neel, Benjamin G.; Bosse, Tjalling; Gaarenstroom, Katja N.; Vrieling, Harry; Vreeswijk, Maaike P. G.; van Diest, Paul J.; Witteveen, Petronella O.; Jonges, Trudy; Bos, Johannes L.; van Oudenaarden, Alexander; Zweemer, Ronald P.; Snippert, Hugo J. G.; Kloosterman 14, Hans Clevers, Wigard P. (2019). "An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity". Nature Medicine. 25 (5): 838–849. doi:10.1038/s41591-019-0422-6. PMID 31011202. S2CID 126428230. Retrieved 29 June 2022.
{{cite journal}}
: CS1 maint: numeric names: authors list (link) - ^ Bartfeld, Sina (2021). "Realizing the potential of organoids—an interview with Hans Clevers". Journal of Molecular Medicine. 99 (4): 443–447. doi:10.1007/s00109-020-02025-3. PMC 8026466. PMID 33464358.
- ^ Bender, Eric (2015). "Q&A: Hans Clevers". Nature. 521 (7551): S15. Bibcode:2015Natur.521S..15B. doi:10.1038/521S15a. PMID 25970453. S2CID 4452738.
- ^ Saini, Angela (2016). "Cystic Fibrosis Patients Benefit from Mini Guts" (PDF). Cell Stem Cell. 19 (4): 425–427. doi:10.1016/j.stem.2016.09.001. Archived from the original (PDF) on 25 June 2022. Retrieved 26 June 2022.
- ^ Lamers, Mart M; van der Vaart, Jelte; Knoops, Kèvin; Riesebosch, Samra; Breugem, Tim I; Mykytyn, Anna Z; Beumer, Joep; Schipper, Debby; Bezstarosti, Karel; Koopman, Charlotte D; Groen, Nathalie; Ravelli, Raimond B G; Duimel, Hans Q; Demmers, Jeroen A A; Verjans, Georges M G M; Koopmans, Marion P G; Muraro, Mauro J; Peters, Peter J; Clevers, Hans; Haagmans, Bart L (2021). "An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells". The EMBO Journal. 40 (5): e105912. doi:10.15252/embj.2020105912. PMC 7883112. PMID 33283287.
- ^ "Hans C. Clevers". European Molecular Biology Organization. Archived from the original on 26 June 2022. Retrieved 26 June 2022.
- ^ "Hans Clevers". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 16 August 2019. Retrieved 16 August 2019.
- ^ "NWO Spinoza Prize 2001". Dutch Research Council. Archived from the original on 31 October 2020. Retrieved 31 October 2020.
- ^ "Professor Hans CLEVERS". Louis-Jeantet Foundation. October 2017. Archived from the original on 26 June 2022. Retrieved 26 June 2022.
- ^ "Die Preisträger" (in German). Meyenburg Foundation. 30 April 2005. Archived from the original on 4 April 2022. Retrieved 26 June 2022.
- ^ "Hans Clevers". Academia Europaea. Archived from the original on 26 June 2022. Retrieved 26 June 2022.
- ^ "Awards & Grants : UEGF Research Prize : EUR 100.000 awarded for the most outstanding research programme". UEGW Barcelona 2010 : 18th United European Gastroenterology Week : Final Programme. United European Gastroenterology Federation (UEGF). 2010. p. 20. Archived from the original on 6 January 2024. Retrieved 6 January 2024.
- ^ "Laureates 1976 to 2021". Ernst Jung Foundation. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
- ^ "William Beaumont Prize in Gastroenterology". American Gastroenterological Association. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
- ^ "Hans Clevers". Heineken Prizes. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
- ^ "Koninklijke onderscheidingen 2012" (in Dutch). Utrecht University. Archived from the original on 9 May 2015. Retrieved 9 May 2015.
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- ^ "Hans Clevers". Breakthrough Prize in Life Sciences. Archived from the original on 14 February 2022. Retrieved 16 April 2022.
- ^ "Hans Clevers". National Academy of Sciences. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
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- ^ "Hans Clevers" (in French). French Academy of Sciences. Archived from the original on 28 June 2022. Retrieved 27 June 2022.
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External links
- Hans Clevers publications indexed by Google Scholar
- 1957 births
- Living people
- Dutch geneticists
- Dutch immunologists
- Fellows of the AACR Academy
- Fellows of the American Academy of Arts and Sciences
- Foreign associates of the National Academy of Sciences
- Foreign Members of the Royal Society
- Honorary Fellows of the Royal Society of Edinburgh
- Knights Commander of the Order of Merit of the Federal Republic of Germany
- Knights of the Order of the Netherlands Lion
- Members of Academia Europaea
- Members of the European Molecular Biology Organization
- Members of the French Academy of Sciences
- Members of the Royal Netherlands Academy of Arts and Sciences
- Recipients of the Pour le Mérite (civil class)
- People from Eindhoven
- Spinoza Prize winners
- Stem cell researchers
- Utrecht University alumni
- Academic staff of Utrecht University
- Winners of the Heineken Prize
- Recipients of the Legion of Honour
- Members of the Koninklijke Hollandsche Maatschappij der Wetenschappen