Hans Clevers: Difference between revisions

Hans Clevers
Hans Clevers
	Clevers in 2018
Born	Johannes Carolus Clevers; 27 March 1957 (age 67); Eindhoven, Netherlands
Nationality	Dutch
Alma mater	University of Utrecht
Known for	Organoid generation and application
Spouse	Eefke Petersen
Children	2
Awards	Louis-Jeantet Prize for Medicine ; Breakthrough Prize in Life Sciences ; Dr A. H. Heineken Prize for Medicine ; Körber European Science Prize
	Scientific career
Fields	Molecular genetics ; Cell biology
Institutions	Roche ; Princess Máxima Center [nl] ; University Medical Center Utrecht ; Hubrecht Institute for Developmental Biology and Stem Cell Research ; Utrecht University ; Dana–Farber Cancer Institute
Thesis	Early events in lymphocyte activation (1985)
Doctoral advisor	Rudy Ballieux

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Johannes (Hans) Carolus Clevers (born 27 March 1957)^[3]^[4] is a Dutch molecular geneticist, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Swiss healthcare company Roche in 2022.^[7]^[8] Previously, he headed a research group at the Hubrecht Institute for Developmental Biology and Stem Cell Research^[9] and at the Princess Máxima Center [nl];^[10] he remained as an advisor and guest scientist or visiting researcher to both groups.^[7] He is also a Professor in Molecular Genetics at the University of Utrecht.^[8]

Early life and education

Hans Clevers was born in Eindhoven, the Netherlands in 1957.^[5] He began studying biology at the University of Utrecht in 1975, but also started taking medicine in 1978,^[7] in part due to his interest and in part because his friends and brothers were in the medical profession.^[11] He spent 1 year in Nairobi, Kenya, and half a year at the National Institutes of Health in Bethesda, United States, for biology rotations.^[11]^[12] He received a Doctoraal (equivalent to an MSc) in Biology in 1982 and an Artsexamen (equivalent to an MD) in 1984. Mostly because of his research background, Clevers was selected for a training position in paediatrics, and then went to pursue a PhD in 1985, under the supervision of Rudy Ballieux.^[1]^[13]^[14] He obtained his PhD 1 year later.^[7]^[11]

Scholia has a profile for Hans Clevers (Q1579050).

Career

After his PhD, Clevers went to the Dana–Farber Cancer Institute as a postdoctoral researcher at Cox Terhorst's group.^[8]^[11]^[15]^[16] In 1989, he returned to the Netherlands, joining his alma mater, the University of Utrecht, as an assistant professor at the Department of Clinical Immunology.^[8]

In 1991, Clevers became a professor and the chair of the Department of Immunology at the University of Utrecht.^[8] He moved to the University Medical Center Utrecht in 2002 as a professor in molecular genetics, and started his lab at the Hubrecht Institute for Developmental Biology and Stem Cell Research (Hubrecht Institute).^[7] At the same time, he took up the position of Director of the Hubrecht Institute.^[8]

In March 2012, Clevers was elected the president of the Royal Netherlands Academy of Arts and Sciences, succeeding Robbert Dijkgraaf.^[17]^[18] His term concluded in 2015, and he started another lab at the Princess Máxima Center [nl],^[8] focusing on childhood cancer,^[10] and became the Director Research and Chief Scientific Officer there until 2019.^[8]

Clevers left University Medical Center Utrecht and was appointed Professor in Molecular Genetics at the University of Utrecht in 2020.^[7]

In 2022, Clevers joined the Swiss healthcare company Roche as its Head of Pharma, Research and Early Development and a member of its Corporate Executive Committee.^[19]^[20] He remains an advisor and guest scientist or visiting researcher to his research groups at the Princess Máxima Center and Hubrecht Institute.^[9]^[10]

Since 2017, Clevers is an investigator at the Oncode Institute in Utrecht.^[7]^[21]

Clevers has served at a number of scientific organizations, including on the board of directors of the American Association for Cancer Research (2013-2016),^[22] and the Scientific Advisory Board of the Swiss Institute for Experimental Cancer Research at the École Polytechnique Fédérale de Lausanne (2005-2015),^[8] the Research Institute of Molecular Pathology in Vienna (2015-2021)^[23] and the Francis Crick Institute in London.^[24] He is currently on the advisory board of various scientific journals, including The EMBO Journal,^[25] Disease Models & Mechanisms,^[26] Cell,^[27] Cell Stem Cell^[28] and EMBO Molecular Medicine.^[29] From 2014 to 2022, he was also on the editorial committee of the Annual Review of Cancer Biology.^[7]

Outside the academia, Clevers has been a scientific advisor to numerous biotechnology companies.^[7] He also co-founded California-based Surrozen^[30] in 2016^[31] and Shanghai-based D1 Medical Technology^[32] in 2019.^[33]

Hans Clevers interviewed for the Dutch television show The Mind of the Universe

Research

Clevers's early career focused on the Wnt signaling pathway.^[34] His group identified the TCF1 protein, a member of the TCF gene family and a crucial downstream component of the Wnt signaling pathway, making it central in immune responses, embryonic development and tissue repair.^[35] His interest in the gastrointestinal tract began with the discovery that another TCF family member, the TCF4 protein, is required in forming intestinal crypts.^[36] Collaborating with Bert Vogelstein, he found that in colon cancer where the APC gene is doubly mutated, TCF family members activate catenin beta-1, which then enhances the expression of many genes that cause cancer transformation,^[37] connecting the Wnt signaling pathway with colon cancer.

In 2007, Clevers's group identified a marker for stem cells of the small and large intestines, LGR5, itself also a target of the Wnt signaling pathway.^[38] This led to his finding that LGR5 is a stem cell marker in other organs as well, including the stomach^[39] and hair follicles.^[40]

Building on this discovery, in 2009, his group published a landmark paper, describing for the first time how organoids, which are 3-dimensional in vitro structures that behave anatomically and molecularly like the organ from which they are derived, were generated from adult stem cells, creating organoids of the small intestine.^[41] Clevers's group has applied this technology to culturing organoids from other organs, such as the stomach^[39] and liver,^[42] as well as from various cancer types, including cancer of the breast^[43] and the ovaries.^[44] This platform has since been applied in personalized medicine, by generating organoids from specific patients to screen for drugs.^[45]^[46] This is not limited to cancer but is applicable to other diseases as well (for example, cystic fibrosis).^[47] His current major research interest is in using organoids derived from adult stem cells to study the molecular mechanism of tissue and cancer development.

During the COVID-19 pandemic, Clevers's group modelled the infection of SARS-CoV-2 using lung organoids.^[48]

Honours and awards

Member of the European Molecular Biology Organization (1999)^[49]
Member of the Royal Netherlands Academy of Arts and Sciences (2000)^[50]
Spinoza Prize (2001)^[51]
Louis-Jeantet Prize for Medicine (2004)^[52]
Knight of the Legion of Honour (2005)^[7]
Meyenburg Prize (2008)^[53]
Member of Academia Europaea (2009)^[54]
United European Gastroenterology Federation Research Prize (2010)^[55]
Ernst Jung Prize for Medicine (2011)^[56]
International Honorary Member of the American Academy of Arts and Sciences (2012)^[2]
William Beaumont Prize (2012)^[57]
Dr A.H. Heineken Prize for Medicine (2012)^[58]
Knight of the Order of the Netherlands Lion (2012)^[59]
Member of Koninklijke Hollandsche Maatschappij der Wetenschappen (2012)^[60]
Breakthrough Prize in Life Sciences (2013)^[61]
International Member of the National Academy of Sciences (2014)^[62]
Fellow of the American Association for Cancer Research Academy^[63]
Foreign Associate of the French Academy of Sciences (2015)^[64]
Pour le Mérite (2016)^[65]^[66]
Körber European Science Prize (2016)^[67]
Knight Commander's Cross of the Order of Merit of the Federal Republic of Germany (2018)^[68]
Foreign Member of the Royal Society (2019)^[69]
Honorary Fellow of the Royal Society of Edinburgh (2019)^[70]
Keio Medical Science Prize (2019)^[71]
The Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research (2021)

References

^ ^a ^b "Mentoring the Next Generation: Hans Clevers". Cell Stem Cell. 23 (6): 784–786. 2018. doi:10.1016/j.stem.2018.11.004. S2CID 239579550.
^ ^a ^b "Johannes Carolus Clevers". American Academy of Arts and Sciences. Archived from the original on 27 June 2022.
^ ^a ^b ^c ^d "2016 – Johannes C. Clevers". Ilse & Helmut Wachter Foundation, Medical University of Innsbruck. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ ^a ^b ^c "Prof.dr. J.C. Clevers" (in Dutch). Utrecht University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ ^a ^b "Prof. dr. J.C. (Hans) Clevers" (in Dutch). University Medical Center Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ Clevers, Hans (1 October 2021). "The development of organoids for cancer research: an ode to the scientific method". Cancer World. Archived from the original on 29 June 2022. Retrieved 29 June 2022.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "CURRICULUM VITAE" (PDF). University of Utrecht. Archived from the original (PDF) on 23 June 2022. Retrieved 23 June 2022.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Prof. Dr. Hans Clevers". Roche. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ ^a ^b "Clevers: Adult stem cell-based organoids". University of Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ ^a ^b ^c "Clevers group". Princess Máxima Center [nl]. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ ^a ^b ^c ^d Clevers, H. (2013). "A gutsy approach to stem cells and signalling: an interview with Hans Clevers". Disease Models & Mechanisms. 6 (5): 1053–1056. doi:10.1242/dmm.013367. PMC 3759325. PMID 24046385. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "Hans Clevers on Becoming a Scientist". Cold Spring Harbor Laboratory. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ Menkhorst, Roos (22 June 2013). "Ik leerde het belang van vertrouwen in mezelf". Trouw (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "Hans Clevers". Breakthrough Prize in Life Sciences. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "Hans Clevers". Hubrecht Institute for Developmental Biology and Stem Cell Research. Archived from the original on 31 December 2011. Retrieved 15 March 2012.
^ "Distinguished Lecture: Hans Clevers - "Gut Stem Cells, Organoids, and Precision Medicine". Columbia University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ van Aartsen, Carina (26 March 2012). "Hans Clevers volgt KNAW-president Robbert Dijkgraaf op". Zorgvisie (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "President: Hans Clevers". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 1 February 2013.
^ "New challenge for Hans Clevers at Roche". Hubrecht Institute for Developmental Biology and Stem Cell Research. 1 February 2022. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "Changes to the Roche Board of Directors and the Corporate Executive Committee" (Press release). Basel: Roche. 1 February 2022. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "Hans Clevers Group". Oncode Institute. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "American Association for Cancer Research Councilors and Directors" (PDF). American Association for Cancer Research. Archived from the original (PDF) on 24 June 2022. Retrieved 24 June 2022.
^ "Former SAB Members". Research Institute of Molecular Pathology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "Hans Clevers". Francis Crick Institute. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "Advisory Board Biographies". The EMBO Journal. Archived from the original on 27 June 2022. Retrieved 24 June 2022.
^ "Editors and Board". Disease Models & Mechanisms. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "Staff and advisory board". Cell. Archived from the original on 27 June 2022. Retrieved 24 June 2022.
^ "Advisory board". Cell Stem Cell. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "Advisory Board Biographies". EMBO Molecular Medicine. Archived from the original on 27 June 2022. Retrieved 24 June 2022.
^ "Hans Clevers, MD, PhD". Surrozen. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "Surrozen to Present at Cowen and Company 40th Annual Health Care Conference". Surrozen (Press release). South San Francisco, California. 2 March 2020. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "创始团队" (in Chinese). D1 Medical Technology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ "丹望医疗完成数千万元天使轮融资，凯风创投领投". Sina (in Chinese). 8 February 2021. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
^ Sinha, Gunjan (2017). "The organoid architect". Science. 357 (6353): 746–749. doi:10.1126/science.357.6353.746. PMID 28839056. Archived from the original on 28 June 2022. Retrieved 28 June 2022.
^ van de Wetering, Marc; Oosterwegel, Mariette; Dooijes, Dennis; Clevers, Hans (1991). "Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box". The EMBO Journal. 10 (1): 123–132. doi:10.1002/j.1460-2075.1991.tb07928.x. PMC 452620. PMID 1989880.
^ Korinek, Vladimir; Barker, Nick; Moerer, Petra; van Donselaar, Elly; Huls, Gerwin; Peters, Peter J.; Clevers, Hans (1997). "Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4". Nature Genetics. 19 (4): 379–383. doi:10.1038/1270. PMID 9697701. S2CID 1052683. Retrieved 28 June 2022.
^ Korinek, Vladimir; Barker, Nick; Morin, Patrice J.; van Wichen, Dick; de Weger, Roel; Kinzler, Kenneth W.; Vogelstein, Bert; Clevers, Hans (1997). "Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC^−/− Colon Carcinoma". Science. 275 (5307): 1784–1787. doi:10.1126/science.275.5307.1784. PMID 9065401. S2CID 33935423. Retrieved 28 June 2022.
^ Barker, Nick; van Es, Johan H.; Kuipers, Jeroen; Kujala, Pekka; van den Born, Maaike; Cozijnsen, Miranda; Haegebarth, Andrea; Korving, Jeroen; Begthel, Harry; Peters, Peter J.; Clevers, Hans (2007). "Identification of stem cells in small intestine and colon by marker gene Lgr5". Nature. 449 (7165): 1003–1007. Bibcode:2007Natur.449.1003B. doi:10.1038/nature06196. PMID 17934449. S2CID 4349637. Retrieved 23 June 2022.
^ ^a ^b Barker, Nick; Huch, Meritxell; Kujala, Pekka; van de Wetering, Marc; Snippert, Hugo J.; van Es, Johan H.; Sato, Toshiro; Stange, Daniel E.; Begthel, Harry; van den Born, Maaike; Danenberg, Esther; van den Brink, Stieneke; Korving, Jeroen; Abo, Arie; Peters, Peter J.; Wright, Nick; Poulsom, Richard; Clevers, Hans (2010). "Lgr5^+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro". Cell Stem Cell. 6 (1): 25–36. doi:10.1016/j.stem.2009.11.013. PMID 20085740.
^ Jaks, Viljar; Barker, Nick; Kasper, Maria; van Es, Johan H; Snippert, Hugo J; Clevers, Hans; Toftgård, Rune (2008). "Lgr5 marks cycling, yet long-lived, hair follicle stem cells". Nature Genetics. 40 (11): 1291–1299. doi:10.1038/ng.239. PMID 18849992. S2CID 10883817. Retrieved 23 June 2022.
^ Sato, Toshiro; Vries, Robert G.; Snippert, Hugo J.; van de Wetering, Marc; Barker, Nick; Stange, Daniel E.; van Es, Johan H.; Abo, Arie; Kujala, Pekka; Peters, Peter J.; Clevers, Hans (2009). "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche". Nature. 459 (7244): 262–265. Bibcode:2009Natur.459..262S. doi:10.1038/nature07935. PMID 19329995. S2CID 4373784. Retrieved 23 June 2022.
^ Huch, Meritxell; Dorrell, Craig; Boj, Sylvia F.; van Es, Johan H.; van de Wetering, Marc; Li, Vivian S.W.; Hamer, Karien; Sasaki, Nobuo; Finegold, Milton J.; Haft, Annelise; Grompe, Markus; Clevers, Hans (2013). "In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration". Nature. 494 (7436): 247–250. Bibcode:2013Natur.494..247H. doi:10.1038/nature11826. PMC 3634804. PMID 23354049.
^ Sachs, Norman; de Ligt, Joep; Kopper, Oded; Gogola, Ewa; Bounova, Gergana; Weeber, Fleur; Vanita Balgobind, Anjali; Wind, Karin; Gracanin, Ana; Begthel, Harry; Korving, Jeroen; van Boxtel, Ruben; Alves Duarte, Alexandra; Lelieveld, Daphne; van Hoeck, Arne; Ernst, Robert Frans; Blokzijl, Francis; Nijman, Isaac Johannes; Hoogstraat, Marlous; van de Ven, Marieke; Egan, David Anthony; Zinzalla, Vittoria; Moll, Jurgen; Fernandez Boj, Sylvia; Voest, Emile Eugene; Wessels, Lodewyk; van Diest, Paul Joannes; Rottenberg, Sven; Vries, Robert Gerhardus Jacob; Cuppen, Edwin; Clevers, Hans (2018). "A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity". Cell. 172 (1–2): 373–386. doi:10.1016/j.cell.2017.11.010. PMID 29224780. S2CID 8951522.
^ Kopper, Oded; de Witte, Chris J.; Lõhmussaar, Kadi; Valle-Inclan, Jose Espejo; Hami, Nizar; Kester, Lennart; Vanita Balgobind, Anjali; Korving, Jeroen; Proost, Natalie; Begthel, Harry; van Wijk, Lise M; Aristín Revilla, Sonia; Theeuwsen, Rebecca; van de Ven, Marieke; van Roosmalen, Markus J; Ponsioen, Bas; Ho, Victor W. H.; Neel, Benjamin G.; Bosse, Tjalling; Gaarenstroom, Katja N.; Vrieling, Harry; Vreeswijk, Maaike P. G.; van Diest, Paul J.; Witteveen, Petronella O.; Jonges, Trudy; Bos, Johannes L.; van Oudenaarden, Alexander; Zweemer, Ronald P.; Snippert, Hugo J. G.; Kloosterman 14, Hans Clevers, Wigard P. (2019). "An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity". Nature Medicine. 25 (5): 838–849. doi:10.1038/s41591-019-0422-6. PMID 31011202. S2CID 126428230. Retrieved 29 June 2022.{{cite journal}}: CS1 maint: numeric names: authors list (link)
^ Bartfeld, Sina (2021). "Realizing the potential of organoids—an interview with Hans Clevers". Journal of Molecular Medicine. 99 (4): 443–447. doi:10.1007/s00109-020-02025-3. PMC 8026466. PMID 33464358.
^ Bender, Eric (2015). "Q&A: Hans Clevers". Nature. 521 (7551): S15. Bibcode:2015Natur.521S..15B. doi:10.1038/521S15a. PMID 25970453. S2CID 4452738.
^ Saini, Angela (2016). "Cystic Fibrosis Patients Benefit from Mini Guts" (PDF). Cell Stem Cell. 19 (4): 425–427. doi:10.1016/j.stem.2016.09.001. Archived from the original (PDF) on 25 June 2022. Retrieved 26 June 2022.
^ Lamers, Mart M; van der Vaart, Jelte; Knoops, Kèvin; Riesebosch, Samra; Breugem, Tim I; Mykytyn, Anna Z; Beumer, Joep; Schipper, Debby; Bezstarosti, Karel; Koopman, Charlotte D; Groen, Nathalie; Ravelli, Raimond B G; Duimel, Hans Q; Demmers, Jeroen A A; Verjans, Georges M G M; Koopmans, Marion P G; Muraro, Mauro J; Peters, Peter J; Clevers, Hans; Haagmans, Bart L (2021). "An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells". The EMBO Journal. 40 (5): e105912. doi:10.15252/embj.2020105912. PMC 7883112. PMID 33283287.
^ "Hans C. Clevers". European Molecular Biology Organization. Archived from the original on 26 June 2022. Retrieved 26 June 2022.
^ "Hans Clevers". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 16 August 2019. Retrieved 16 August 2019.
^ "NWO Spinoza Prize 2001". Dutch Research Council. Archived from the original on 31 October 2020. Retrieved 31 October 2020.
^ "Professor Hans CLEVERS". Louis-Jeantet Foundation. October 2017. Archived from the original on 26 June 2022. Retrieved 26 June 2022.
^ "Die Preisträger" (in German). Meyenburg Foundation. 30 April 2005. Archived from the original on 4 April 2022. Retrieved 26 June 2022.
^ "Hans Clevers". Academia Europaea. Archived from the original on 26 June 2022. Retrieved 26 June 2022.
^ "Awards & Grants : UEGF Research Prize : EUR 100.000 awarded for the most outstanding research programme". UEGW Barcelona 2010 : 18th United European Gastroenterology Week : Final Programme. United European Gastroenterology Federation (UEGF). 2010. p. 20. Archived from the original on 6 January 2024. Retrieved 6 January 2024.
^ "Laureates 1976 to 2021". Ernst Jung Foundation. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "William Beaumont Prize in Gastroenterology". American Gastroenterological Association. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers". Heineken Prizes. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "Koninklijke onderscheidingen 2012" (in Dutch). Utrecht University. Archived from the original on 9 May 2015. Retrieved 9 May 2015.
^ "NIEUWE LEDEN" (PDF). Jaarverslag 2012. Koninklijke Hollandsche Maatschappij der Wetenschappen. Archived from the original (PDF) on 27 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers". Breakthrough Prize in Life Sciences. Archived from the original on 14 February 2022. Retrieved 16 April 2022.
^ "Hans Clevers". National Academy of Sciences. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers, MD, PhD". American Association for Cancer Research. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers" (in French). French Academy of Sciences. Archived from the original on 28 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers" (in German). Pour le Mérite für Wissenschaften und Künste. Archived from the original on 28 June 2022. Retrieved 27 June 2022.
^ "Hans CLEVERS" (PDF). Pour le Mérite für Wissenschaften und Künste. Archived from the original (PDF) on 27 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers (2016): Replacement organs from a petri dish". Körber Foundation. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "German award for Hans Clevers". Princess Máxima Center. 2 March 2018. Archived from the original on 27 June 2022. Retrieved 27 June 2022.
^ "Hans Clevers". Royal Society. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
^ "Professor Johannes Carolus Clevers ForMemRS, HonFRSE". Royal Society of Edinburgh. Archived from the original on 1 August 2020. Retrieved 1 August 2020.
^ "Hans C. Clevers" (in Japanese). Keio University. Archived from the original on 15 May 2020. Retrieved 27 June 2022.

External links

Hans Clevers publications indexed by Google Scholar

[cellstemcell-1] "Mentoring the Next Generation: Hans Clevers". Cell Stem Cell. 23 (6): 784–786. 2018. doi:10.1016/j.stem.2018.11.004. S2CID 239579550.

[aaas-2] "Johannes Carolus Clevers". American Academy of Arts and Sciences. Archived from the original on 27 June 2022.

[wachter-3] "2016 – Johannes C. Clevers". Ilse & Helmut Wachter Foundation, Medical University of Innsbruck. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[catalogus-4] "Prof.dr. J.C. Clevers" (in Dutch). Utrecht University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[umc-5] "Prof. dr. J.C. (Hans) Clevers" (in Dutch). University Medical Center Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[6] Clevers, Hans (1 October 2021). "The development of organoids for cancer research: an ode to the scientific method". Cancer World. Archived from the original on 29 June 2022. Retrieved 29 June 2022.

[cv-7] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "CURRICULUM VITAE" (PDF). University of Utrecht. Archived from the original (PDF) on 23 June 2022. Retrieved 23 June 2022.

[roche-8] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Prof. Dr. Hans Clevers". Roche. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[hubrecht-9] "Clevers: Adult stem cell-based organoids". University of Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[princess-10] "Clevers group". Princess Máxima Center [nl]. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[dmm-11] Clevers, H. (2013). "A gutsy approach to stem cells and signalling: an interview with Hans Clevers". Disease Models & Mechanisms. 6 (5): 1053–1056. doi:10.1242/dmm.013367. PMC 3759325. PMID 24046385. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[12] "Hans Clevers on Becoming a Scientist". Cold Spring Harbor Laboratory. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[13] Menkhorst, Roos (22 June 2013). "Ik leerde het belang van vertrouwen in mezelf". Trouw (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[14] "Hans Clevers". Breakthrough Prize in Life Sciences. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[hubr-15] "Hans Clevers". Hubrecht Institute for Developmental Biology and Stem Cell Research. Archived from the original on 31 December 2011. Retrieved 15 March 2012.

[16] "Distinguished Lecture: Hans Clevers - "Gut Stem Cells, Organoids, and Precision Medicine". Columbia University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[17] van Aartsen, Carina (26 March 2012). "Hans Clevers volgt KNAW-president Robbert Dijkgraaf op". Zorgvisie (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[18] "President: Hans Clevers". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 1 February 2013.

[19] "New challenge for Hans Clevers at Roche". Hubrecht Institute for Developmental Biology and Stem Cell Research. 1 February 2022. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[20] "Changes to the Roche Board of Directors and the Corporate Executive Committee" (Press release). Basel: Roche. 1 February 2022. Archived from the original on 23 June 2022. Retrieved 23 June 2022.

[21] "Hans Clevers Group". Oncode Institute. Archived from the original on 24 June 2022. Retrieved 24 June 2022.

[22] "American Association for Cancer Research Councilors and Directors" (PDF). American Association for Cancer Research. Archived from the original (PDF) on 24 June 2022. Retrieved 24 June 2022.

[23] "Former SAB Members". Research Institute of Molecular Pathology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.

[24] "Hans Clevers". Francis Crick Institute. Archived from the original on 24 June 2022. Retrieved 24 June 2022.

[25] "Advisory Board Biographies". The EMBO Journal. Archived from the original on 27 June 2022. Retrieved 24 June 2022.

[26] "Editors and Board". Disease Models & Mechanisms. Archived from the original on 24 June 2022. Retrieved 24 June 2022.

[27] "Staff and advisory board". Cell. Archived from the original on 27 June 2022. Retrieved 24 June 2022.

[28] "Advisory board". Cell Stem Cell. Archived from the original on 24 June 2022. Retrieved 24 June 2022.

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v t e Fellows of the Royal Society elected in 2019
Fellows	Salim Abdool Karim Charles Bangham Gurdyal Besra Manjul Bhargava Caucher Birkar Benjamin Blencowe James Briscoe Peter A. Butler Lucy Carpenter Sarah Darby George Davey Smith Martin Embley Bernie Fanaroff Jonathan Flint Véronique Gouverneur Christopher Hacon Mark Handley Richard Harland Peter H. Haynes Martin Head-Gordon Matthew Hurles Richard Jozsa Gagandeep Kang Steve A. Kay John-Michael Kendall Roy Kerr Jonathan C. Knight Marta Kwiatkowska Mark Mayer Gareth H. McKinley David G. Nicholls Christine Orengo Anne Osbourn Anant Parekh Julian Peto Caetano Reis e Sousa John Rodenburg Matthew Rushworth Leonid Sazanov Gregory D. Scholes Barbara Sherwood Lollar Molly Shoichet Liz Sockett Paraskevas Sphicas Jack W. Szostak Andrew D. Taylor Robert Tibshirani Ian Tomlinson Douglass Turnbull Akshay Venkatesh Kumar Wickramasinghe
Honorary	Yusuf Hamied
Foreign	Barry Barish Hans Clevers Sandra Díaz Jack Dongarra Elaine Fuchs Inez Fung David Milstein Akkihebbal Ravishankara James Rothman Brian Staskawicz

v t e Breakthrough Prize laureates
Mathematics	Simon Donaldson, Maxim Kontsevich, Jacob Lurie, Terence Tao and Richard Taylor (2015) Ian Agol (2016) Jean Bourgain (2017) Christopher Hacon, James McKernan (2018) Vincent Lafforgue (2019) Alex Eskin (2020) Martin Hairer (2021) Takuro Mochizuki (2022) Daniel A. Spielman (2023) Simon Brendle (2024)
Fundamental physics	Nima Arkani-Hamed, Alan Guth, Alexei Kitaev, Maxim Kontsevich, Andrei Linde, Juan Maldacena, Nathan Seiberg, Ashoke Sen, Edward Witten (2012) Special: Stephen Hawking, Peter Jenni, Fabiola Gianotti (ATLAS), Michel Della Negra, Tejinder Virdee, Guido Tonelli, Joseph Incandela (CMS) and Lyn Evans (LHC) (2013) Alexander Polyakov (2013) Michael Green and John Henry Schwarz (2014) Saul Perlmutter and members of the Supernova Cosmology Project; Brian Schmidt, Adam Riess and members of the High-Z Supernova Team (2015) Special: Ronald Drever, Kip Thorne, Rainer Weiss and contributors to LIGO project (2016) Yifang Wang, Kam-Biu Luk and the Daya Bay team, Atsuto Suzuki and the KamLAND team, Kōichirō Nishikawa and the K2K / T2K team, Arthur B. McDonald and the Sudbury Neutrino Observatory team, Takaaki Kajita and Yōichirō Suzuki and the Super-Kamiokande team (2016) Joseph Polchinski, Andrew Strominger, Cumrun Vafa (2017) Charles L. Bennett, Gary Hinshaw, Norman Jarosik, Lyman Page Jr., David Spergel (2018) Special: Jocelyn Bell Burnell (2018) Charles Kane and Eugene Mele (2019) Special: Sergio Ferrara, Daniel Z. Freedman, Peter van Nieuwenhuizen (2019) The Event Horizon Telescope Collaboration (2020) Eric Adelberger, Jens H. Gundlach and Blayne Heckel (2021) Special: Steven Weinberg (2021) Hidetoshi Katori and Jun Ye (2022) Charles H. Bennett, Gilles Brassard, David Deutsch, Peter W. Shor (2023) John Cardy and Alexander Zamolodchikov (2024)
Life sciences	Cornelia Bargmann, David Botstein, Lewis C. Cantley, Hans Clevers, Titia de Lange, Napoleone Ferrara, Eric Lander, Charles Sawyers, Robert Weinberg, Shinya Yamanaka and Bert Vogelstein (2013) James P. Allison, Mahlon DeLong, Michael N. Hall, Robert S. Langer, Richard P. Lifton and Alexander Varshavsky (2014) Alim Louis Benabid, Charles David Allis, Victor Ambros, Gary Ruvkun, Jennifer Doudna and Emmanuelle Charpentier (2015) Edward Boyden, Karl Deisseroth, John Hardy, Helen Hobbs and Svante Pääbo (2016) Stephen J. Elledge, Harry F. Noller, Roeland Nusse, Yoshinori Ohsumi, Huda Zoghbi (2017) Joanne Chory, Peter Walter, Kazutoshi Mori, Kim Nasmyth, Don W. Cleveland (2018) C. Frank Bennett and Adrian R. Krainer, Angelika Amon, Xiaowei Zhuang, Zhijian Chen (2019) Jeffrey M. Friedman, Franz-Ulrich Hartl, Arthur L. Horwich, David Julius, Virginia Man-Yee Lee (2020) David Baker, Catherine Dulac, Dennis Lo, Richard J. Youle [de] (2021) Jeffery W. Kelly, Katalin Karikó, Drew Weissman, Shankar Balasubramanian, David Klenerman and Pascal Mayer (2022) Clifford P. Brangwynne, Anthony A. Hyman, Demis Hassabis, John Jumper, Emmanuel Mignot, Masashi Yanagisawa (2023) Carl June, Michel Sadelain, Sabine Hadida, Paul Negulescu, Fredrick Van Goor, Thomas Gasser, Ellen Sidransky and Andrew Singleton (2024)

v t e Heineken Prizes
Biochemistry and Biophysics	Chargaff (1964) Brachet (1967) Chance (1970) De Duve (1973) Van Deenen (1976) Klug (1979) Weissmann (1982) Julesz & Reichardt (1985) Cech (1988) Leder (1990) Borst (1992) Berridge (1994) Nurse (1996) Pawson (1998) Rothman (2000) Tsien (2002) Fire (2004) Jeffreys (2006) Szostak (2008) Hartl (2010) De Lange (2012) Dobson (2014) Doudna (2016) Zhuang (2018) Stillman (2020)
Medicine	Lauterbur (1989) Van Rood (1990) Moncada (1992) Montagnier (1994) De Wied (1996) Marshall (1998) Kandel (2000) Selkoe (2002) Blackburn (2004) King (2006) Peto (2008) Steinman (2010) Clevers (2012) Alitalo (2014) Jackson (2016) Carmeliet (2018) Deisseroth (2020)
Environmental Sciences	Lovelock (1990) Branica (1992) BirdLife International (1994) Daly (1996) Ehrlich (1998) Harremoës (2000) Thompson (2002) Levin (2004) Pimm (2006) Brunekreef (2008) Tilman (2010) Laurance (2012) Sinninghe Damsté (2014) Mace (2016) Hebert (2018) Le Quéré (2020)
History	Gay (1990) Van der Wee (1992) Brown (1994) Oberman (1996) Ozouf (1998) De Vries (2000) Schilling (2002) Le Goff (2004) Mokyr (2006) Israel (2008) McKitterick (2010) Parker (2012) Assmann (2014) Herrin (2016) McNeill (2018) Daston (2020)
Cognitive Science	Anderson (2006) Dehaene (2008) Tomasello (2010) Duncan (2012) McClelland (2014) Spelke (2016) Kanwisher (2018) Zatorre (2020)
Art	Verhoef (1988) Bot (1990) C. Visser (1992) Röling (1994) Martens (1996) Van de Pavert (1998) Geelen (2000) Mik (2002) Van Golden (2004) Koelewijn (2006) B. Visser (2008) Manders (2010) Struycken (2012) Van Oldenborgh (2014) Dröge Wendel (2016) Van Lieshout (2018) Blom (2020)

Authority control databases
International	ISNI VIAF WorldCat
National	Germany Israel United States Netherlands
Academics	Google Scholar ORCID ResearcherID Scopus