Elaine Mardis: Difference between revisions
m WP:CHECKWIKI error fix for #61. Punctuation goes before References. Do general fixes if a problem exists. - using AWB (8853) |
removed Category:Washington University in St. Louis faculty using HotCat |
||
(45 intermediate revisions by 29 users not shown) | |||
Line 1: | Line 1: | ||
{{short description|American geneticist}} |
|||
{{Infobox scientist |
{{Infobox scientist |
||
| name = Elaine Mardis |
| name = Elaine Mardis |
||
| image = |
| image = |
||
| |
| caption = |
||
| |
| birth_date = |
||
| |
| birth_place = |
||
⚫ | |||
| birth_date = {{Birth date and age|1962|09|28}} {{Citation needed|date=August 2011}} |
|||
| |
| death_place = |
||
⚫ | |||
| death_date = <!-- {{Death date and age|YYYY|MM|DD|YYYY|MM|DD}} (death date then birth date) --> |
|||
| |
| alma_mater = [[University of Oklahoma]] |
||
⚫ | |||
| residence = |
|||
'''Elaine R. Mardis''' (born September 28, 1962) is the co-executive director of the Institute for Genomic Medicine at [[Nationwide Children's Hospital]], where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine.<ref name=":0">{{cite web|url=https://www.nationwidechildrens.org/find-a-doctor/profiles/elaine-r-mardis|title=Nationwide Children's Hospital: Find a Doctor|accessdate=May 1, 2019}}</ref> She also is professor of pediatrics at the [[Ohio State University College of Medicine]].<ref>{{cite web|url=https://www.thelantern.com/2018/06/letter-to-the-editor-nation-leading-osu-cancer-researchers-worry-will-bidens-moonshot-continue/|title=The Lantern|date=26 June 2018|accessdate=May 1, 2019}}</ref> Mardis’s research focuses on the genomic characterization of cancer and its implications for cancer medicine.<ref name=":1">{{cite web|url=http://2017duke.pmwcintl.com/elaine-mardis/|title=PMWC Speaker Biography|accessdate=May 1, 2019}}</ref> She was part of the team that reported the first next-generation-based sequencing of a whole cancer genome,<ref>{{cite journal|title=DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome|journal=[[Nature (journal)|Nature]]|volume=456|issue=7218|pages=66–72|year=2008|doi=10.1038/nature07485|pmc=2603574|pmid=18987736|last1=Ley|first1=Timothy J.|last2=Mardis|first2=Elaine R.|last3=Ding|first3=Li|last4=Fulton|first4=Bob|last5=McLellan|first5=Michael D.|last6=Chen|first6=Ken|last7=Dooling|first7=David|last8=Dunford-Shore|first8=Brian H.|last9=McGrath|first9=Sean|last10=Hickenbotham|first10=Matthew|last11=Cook|first11=Lisa|last12=Abbott|first12=Rachel|last13=Larson|first13=David E.|last14=Koboldt|first14=Dan C.|last15=Pohl|first15=Craig|last16=Smith|first16=Scott|last17=Hawkins|first17=Amy|last18=Abbott|first18=Scott|last19=Locke|first19=Devin|last20=Hillier|first20=Ladeana W.|last21=Miner|first21=Tracie|last22=Fulton|first22=Lucinda|last23=Magrini|first23=Vincent|last24=Wylie|first24=Todd|last25=Glasscock|first25=Jarret|last26=Conyers|first26=Joshua|last27=Sander|first27=Nathan|last28=Shi|first28=Xiaoqi|last29=Osborne|first29=John R.|last30=Minx|first30=Patrick|display-authors=29|bibcode=2008Natur.456...66L}}</ref><ref>{{cite news|url=https://www.nytimes.com/2008/11/06/health/research/06cancer.html|title="Scientists Decode Set of Cancer Genes." New York Times, November 5, 2008.|author=Grady, Denise|date=November 6, 2008|work=[[The New York Times]]|accessdate=May 1, 2019}}</ref> and participated extensively in [[The Cancer Genome Atlas]] (TCGA) and the Pediatric Cancer Genome Project (PCGP).<ref name=":1"/><ref>{{cite web|url=https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga/history/timeline|title=The Cancer Genome Atlas Timeline & Milestones.|publisher=National Cancer Institute|accessdate=May 1, 2019|date=2018-06-13}}</ref><ref name=":2">{{cite journal|title=Comprehensive genomic characterization defines human glioblastoma genes and core pathways|journal=Nature|volume=455|issue=7216|pages=1061–1068|year=2008|doi=10.1038/nature07385|pmc=2671642|pmid=18772890|author1=Cancer Genome Atlas Research Network|bibcode=2008Natur.455.1061M|last2=Friedman|first2=Allan|last3=Bigner|first3=Darrell|last4=Van Meir|first4=Erwin G.|last5=Brat|first5=Daniel J.|last6=m. Mastrogianakis|first6=Gena|last7=Olson|first7=Jeffrey J.|last8=Mikkelsen|first8=Tom|last9=Lehman|first9=Norman|last10=Aldape|first10=Ken|last11=Alfred Yung|first11=W. K.|last12=Bogler|first12=Oliver|last13=Vandenberg|first13=Scott|last14=Berger|first14=Mitchel|last15=Prados|first15=Michael|last16=Muzny|first16=Donna|last17=Morgan|first17=Margaret|last18=Scherer|first18=Steve|last19=Sabo|first19=Aniko|last20=Nazareth|first20=Lynn|last21=Lewis|first21=Lora|last22=Hall|first22=Otis|last23=Zhu|first23=Yiming|last24=Ren|first24=Yanru|last25=Alvi|first25=Omar|last26=Yao|first26=Jiqiang|last27=Hawes|first27=Alicia|last28=Jhangiani|first28=Shalini|last29=Fowler|first29=Gerald|last30=San Lucas|first30=Anthony|display-authors=29}}</ref><ref>{{cite journal|title=Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas|journal=[[Nature Genetics]]|year=2013|volume=45|issue=6|pages=602–612|doi=10.1038/ng.2611|pmc=3727232|pmid=23583981|last1=Zhang|first1=J.|last2=Wu|first2=G.|last3=Miller|first3=C. P.|last4=Tatevossian|first4=R. G.|last5=Dalton|first5=J. D.|last6=Tang|first6=B.|last7=Orisme|first7=W.|last8=Punchihewa|first8=C.|last9=Parker|first9=M.|last10=Qaddoumi|first10=I.|last11=Boop|first11=F. A.|last12=Lu|first12=C.|last13=Kandoth|first13=C.|last14=Ding|first14=L.|last15=Lee|first15=R.|last16=Huether|first16=R.|last17=Chen|first17=X.|last18=Hedlund|first18=E.|last19=Nagahawatte|first19=P.|last20=Rusch|first20=M.|last21=Boggs|first21=K.|last22=Cheng|first22=J.|last23=Becksfort|first23=J.|last24=Ma|first24=J.|last25=Song|first25=G.|last26=Li|first26=Y.|last27=Wei|first27=L.|last28=Wang|first28=J.|last29=Shurtleff|first29=S.|last30=Easton|first30=J.|display-authors=29}}</ref> |
|||
| citizenship = |
|||
| nationality = |
|||
| fields = |
|||
⚫ | |||
⚫ | |||
| doctoral_advisor = |
|||
| academic_advisors = |
|||
| doctoral_students = |
|||
| notable_students = |
|||
| known_for = |
|||
| author_abbrev_bot = |
|||
| author_abbrev_zoo = |
|||
| influences = |
|||
| influenced = |
|||
| awards = |
|||
| signature = <!--(filename only)--> |
|||
| signature_alt = |
|||
| footnotes = |
|||
| spouse = |
|||
}}'''Elaine R Mardis''' (born September 28, 1962) is an American Professor of [[Genetics]], with an adjunct appointment in the Department of [[Molecular microbiology]] at [[Washington University in St. Louis]]<ref>[http://genome.wustl.edu/people/mardis_elaine WUSTL Bio]</ref> and Co-Director of [[The Genome Institute]]. Dr. Mardis is also the Director of The Genome Institute's Technology Development group, a group that researches, tests and implements new sequencing technologies.<ref>{{cite pmid| 21307932 }}</ref><ref>[http://genome.wustl.edu/people/mardis_elaine Genome Institute Bio]</ref><ref>{{cite doi|10.1038/35057062}}</ref> Using next-generation sequencing technology,<ref>{{cite doi|10.1186.2Fgb-2006-7-7-112}}</ref> her group is developing applications and processes for use in The Genome Institute’s sequencing projects.<ref>[http://www.genomeweb.com/sequencing/qa-wash-us-elaine-mardis-testing-new-sequencing-tech-large-genome-center "Q&A: Wash U's Elaine Mardis on Testing New Sequencing Tech for a Large Genome Center."] ''GenomeWeb In Sequence''. 17 February 2009.</ref> Dr. Mardis also helped lead the group that sequenced the first whole cancer genome<ref>[http://www.cbsnews.com/stories/2008/11/06/eveningnews/main4580721.shtml "Scientists Decode Cancer Cell DNA."] ''CBS Evening News''. 6 November 2008.</ref> and has since gone on to sequence many other cancer genomes to determine the genetic changes that may lead to cancer.<ref>{{cite pmid|19657110}}</ref><ref>[http://news.bbc.co.uk/2/hi/health/8184950.stm "Cancer gene complexity revealed"] ''BBC News.'' 7 August 2009.</ref> Other research Dr. Mardis participates in includes human genetic variation<ref>[http://www.1000genomes.org/page.php?page=participants Steering Committee Member,] [[1000 Genomes Project]]</ref> and genomics education.<ref>[http://gep.wustl.edu/sidetables/members_info.php Member, Genomics Education Partnership]</ref> |
|||
==Biography== |
|||
Dr. Mardis serves as chair of the Basic and Translational Sciences Committee for the [[American College of Surgeons Oncology Group]] (ACOSOG).<ref>[http://www.facs.org/news/genome-acosog032610.html Chair, ACOSOG Basic and Translational Sciences Committee]. American College of Surgeons Oncology Group. 2010.</ref> In 2011, she received the Distinguished Alumni Award from the [[University of Oklahoma College of Arts and Sciences]].<ref>[http://cas.ou.edu/2011-daa-and-dsa Distinguished Alumni Award]. University of Oklahoma. 2011.</ref> She also received the Scripps Translational Research award for her work on cancer genomics in 2010.<ref>[http://www.genomeweb.com/people-news-67 Scripps Genomic Medicine award]. Scripps Research Institute. 2010.</ref> |
|||
Mardis was born in [[North Platte, Nebraska]]. She gained a passion for science at an early age, and credits her father, a chemistry professor for more than 30 years, for nurturing this passion.<ref name=":3">{{cite journal|title=Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis|journal=Disease Models & Mechanisms|volume=7|year=2014|issue=3|pages=313–317|doi=10.1242/dmm.015396|pmid=24609032|pmc=3944491|last1=Mardis|first1=E.|last2=Dhillon|first2=P.}}</ref><ref name=":4">{{cite web |author=Arbanas, Caroline |date=September 10, 2008 |title=Genome technology wizard |url=https://source.wustl.edu/2008/09/genome-technology-wizard/ |accessdate=May 1, 2019 |publisher=The Source, [[Washington University in St. Louis]]}}</ref> |
|||
She received her undergraduate degree in Zoology from the [[University of Oklahoma]] in 1984.<ref name=":0"/> During her senior year she took a course in biochemistry that was taught by Bruce Roe, PhD, which says opened her eyes to the world of molecular biology.<ref name=":3"/> She stayed at the University of Oklahoma for her doctoral studies under the supervision of Dr. Roe, who was one of the first academic scientists to have a fluorescent DNA sequencer in the laboratory.<ref name=":4"/> As a result, during her doctoral work Mardis learned the art of DNA sequencing, at a time when few others were doing this.<ref name=":3"/><ref name=":4"/> |
|||
Prior to joining the Washington University faculty, she was a senior research scientist at [[Bio-Rad Laboratories]] in [[Hercules, California]]. She received her [[Bachelor of Science]] degree in 1984 and her [[Ph.D.]] in 1989 from the [[University of Oklahoma]].<ref>[http://www.genomeweb.com/sequencing/qa-wash-us-elaine-mardis-testing-new-sequencing-tech-large-genome-center "Q&A: Wash U's Elaine Mardis on Testing New Sequencing Tech for a Large Genome Center"] ''GenomeWeb In Sequence.'' 17 February 2009.</ref> |
|||
After obtaining her PhD in chemistry and biochemistry in 1989, Mardis did postgraduate work in industry at [[Bio-Rad Laboratories]] in [[Hercules, California]].<ref name=":0"/> |
|||
In 1993, Mardis joined the faculty of [[Washington University School of Medicine]].<ref name=":0"/> Over the next 23 years, she held several and academic and leadership roles at the University, including serving as co-director of the [[McDonnell Genome Institute]].<ref name=":1"/> In that position, she contributed substantially to the sequencing and analysis of the human genome,<ref>{{cite web|url=https://source.wustl.edu/2004/10/genome-center-is-major-contributor-to-finished-human-genome-sequence/|author=Purddy, Michael C.|title=Genome center is major contributor to 'finished' human genome sequence|publisher=Washington University in St. Louis|date=October 21, 2004|accessdate=May 1, 2019}}</ref> and was instrumental in establishing the utility of massively parallel sequencing technologies for understanding cancer biology.<ref name=":1"/> Her work in cancer genetics and genomics has provided insights into the genetic drivers of many types of cancer, including [[acute myeloid leukemia]],<ref name=":2"/><ref>{{cite journal|title=Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome|journal=[[The New England Journal of Medicine]]|year=2009|volume=361|issue=11|pages=1058–1066|doi=10.1056/NEJMoa0903840|pmc=3201812|pmid=19657110|last1=Mardis|first1=Elaine R.|last2=Ding|first2=Li|last3=Dooling|first3=David J.|last4=Larson|first4=David E.|last5=McLellan|first5=Michael D.|last6=Chen|first6=Ken|last7=Koboldt|first7=Daniel C.|last8=Fulton|first8=Robert S.|last9=Delehaunty|first9=Kim D.|last10=McGrath|first10=Sean D.|last11=Fulton|first11=Lucinda A.|last12=Locke|first12=Devin P.|last13=Magrini|first13=Vincent J.|last14=Abbott|first14=Rachel M.|last15=Vickery|first15=Tammi L.|last16=Reed|first16=Jerry S.|last17=Robinson|first17=Jody S.|last18=Wylie|first18=Todd|last19=Smith|first19=Scott M.|last20=Carmichael|first20=Lynn|last21=Eldred|first21=James M.|last22=Harris|first22=Christopher C.|last23=Walker|first23=Jason|last24=Peck|first24=Joshua B.|last25=Du|first25=Feiyu|last26=Dukes|first26=Adam F.|last27=Sanderson|first27=Gabriel E.|last28=Brummett|first28=Anthony M.|last29=Clark|first29=Eric|last30=McMichael|first30=Joshua F.|display-authors=29}}</ref><ref>{{cite journal|title=Clonal evolution in relapsed acute myeloid leukemia revealed by whole-genome sequencing|journal=Nature|year=2012|volume=481|issue=7382|pages=506–10|doi=10.1038/nature10738|pmc=3267864|pmid=22237025|last1=Ding|first1=Li|last2=Ley|first2=Timothy J.|last3=Larson|first3=David E.|last4=Miller|first4=Christopher A.|last5=Koboldt|first5=Daniel C.|last6=Welch|first6=John S.|last7=Ritchey|first7=Julie K.|last8=Young|first8=Margaret A.|last9=Lamprecht|first9=Tamara|last10=McLellan|first10=Michael D.|last11=McMichael|first11=Joshua F.|last12=Wallis|first12=John W.|last13=Lu|first13=Charles|last14=Shen|first14=Dong|last15=Harris|first15=Christopher C.|last16=Dooling|first16=David J.|last17=Fulton|first17=Robert S.|last18=Fulton|first18=Lucinda L.|last19=Chen|first19=Ken|last20=Schmidt|first20=Heather|last21=Kalicki-Veizer|first21=Joelle|last22=Magrini|first22=Vincent J.|last23=Cook|first23=Lisa|last24=McGrath|first24=Sean D.|last25=Vickery|first25=Tammi L.|last26=Wendl|first26=Michael C.|last27=Heath|first27=Sharon|last28=Watson|first28=Mark A.|last29=Link|first29=Daniel C.|last30=Tomasson|first30=Michael H.|display-authors=29|bibcode=2012Natur.481..506D}}</ref> [[breast cancer]],<ref>{{cite journal|title=Whole-genome analysis informs breast cancer response to aromatase inhibition.|journal=Nature|year=2012|volume=486|issue=7403|pages=353–60|doi=10.1038/nature11143|pmc=3383766|pmid=22722193|last1=Ellis|first1=Matthew J.|last2=Ding|first2=Li|last3=Shen|first3=Dong|last4=Luo|first4=Jingqin|last5=Suman|first5=Vera J.|last6=Wallis|first6=John W.|last7=Van Tine|first7=Brian A.|last8=Hoog|first8=Jeremy|last9=Goiffon|first9=Reece J.|last10=Goldstein|first10=Theodore C.|last11=Ng|first11=Sam|last12=Lin|first12=Li|last13=Crowder|first13=Robert|last14=Snider|first14=Jacqueline|last15=Ballman|first15=Karla|last16=Weber|first16=Jason|last17=Chen|first17=Ken|last18=Koboldt|first18=Daniel C.|last19=Kandoth|first19=Cyriac|last20=Schierding|first20=William S.|last21=McMichael|first21=Joshua F.|last22=Miller|first22=Christopher A.|last23=Lu|first23=Charles|last24=Harris|first24=Christopher C.|last25=McLellan|first25=Michael D.|last26=Wendl|first26=Michael C.|last27=Deschryver|first27=Katherine|last28=Allred|first28=D. Craig|last29=Esserman|first29=Laura|last30=Unzeitig|first30=Gary|display-authors=29|bibcode=2012Natur.486..353E}}</ref><ref>{{cite journal|title=The prognostic effects of somatic mutations in ER-positive breast cancer.|journal=[[Nature Communications]]|year=2018|volume=9|issue=1|page=3476|doi=10.1038/s41467-018-05914-x|pmc=6123466|pmid=30181556|last1=Griffith|first1=Obi L.|last2=Spies|first2=Nicholas C.|last3=Anurag|first3=Meenakshi|last4=Griffith|first4=Malachi|last5=Luo|first5=Jingqin|last6=Tu|first6=Dongsheng|last7=Yeo|first7=Belinda|last8=Kunisaki|first8=Jason|last9=Miller|first9=Christopher A.|last10=Krysiak|first10=Kilannin|last11=Hundal|first11=Jasreet|last12=Ainscough|first12=Benjamin J.|last13=Skidmore|first13=Zachary L.|last14=Campbell|first14=Katie|last15=Kumar|first15=Runjun|last16=Fronick|first16=Catrina|last17=Cook|first17=Lisa|last18=Snider|first18=Jacqueline E.|last19=Davies|first19=Sherri|last20=Kavuri|first20=Shyam M.|last21=Chang|first21=Eric C.|last22=Magrini|first22=Vincent|last23=Larson|first23=David E.|last24=Fulton|first24=Robert S.|last25=Liu|first25=Shuzhen|last26=Leung|first26=Samuel|last27=Voduc|first27=David|last28=Bose|first28=Ron|last29=Dowsett|first29=Mitch|last30=Wilson|first30=Richard K.|display-authors=29|bibcode=2018NatCo...9.3476G}}</ref> [[glioblastoma]],<ref>{{cite journal|title=Comprehensive genomic characterization defines human glioblastoma genes and core pathways.|journal=Nature|year=2008|volume=455|issue=7216|pages=1061–8|doi=10.1038/nature07385|pmc=2671642|pmid=18772890|bibcode=2008Natur.455.1061M|last1=McLendon|first1=Roger|last2=Friedman|first2=Allan|last3=Bigner|first3=Darrell|last4=Van Meir|first4=Erwin G.|last5=Brat|first5=Daniel J.|last6=m. Mastrogianakis|first6=Gena|last7=Olson|first7=Jeffrey J.|last8=Mikkelsen|first8=Tom|last9=Lehman|first9=Norman|last10=Aldape|first10=Ken|last11=Alfred Yung|first11=W. K.|last12=Bogler|first12=Oliver|last13=Vandenberg|first13=Scott|last14=Berger|first14=Mitchel|last15=Prados|first15=Michael|last16=Muzny|first16=Donna|last17=Morgan|first17=Margaret|last18=Scherer|first18=Steve|last19=Sabo|first19=Aniko|last20=Nazareth|first20=Lynn|last21=Lewis|first21=Lora|last22=Hall|first22=Otis|last23=Zhu|first23=Yiming|last24=Ren|first24=Yanru|last25=Alvi|first25=Omar|last26=Yao|first26=Jiqiang|last27=Hawes|first27=Alicia|last28=Jhangiani|first28=Shalini|last29=Fowler|first29=Gerald|last30=San Lucas|first30=Anthony|display-authors=29}}</ref> and [[Adenocarcinoma of the lung|lung adenocarcinoma]].<ref>{{cite journal|title=Somatic mutations affect key pathways in lung adenocarcinoma.|journal=Nature|year=2008|volume=455|issue=7216|pages=1069–75|doi=10.1038/nature07423|pmc=2694412|pmid=18948947|last1=Ding|first1=Li|last2=Getz|first2=Gad|last3=Wheeler|first3=David A.|last4=Mardis|first4=Elaine R.|last5=McLellan|first5=Michael D.|last6=Cibulskis|first6=Kristian|last7=Sougnez|first7=Carrie|last8=Greulich|first8=Heidi|last9=Muzny|first9=Donna M.|last10=Morgan|first10=Margaret B.|last11=Fulton|first11=Lucinda|last12=Fulton|first12=Robert S.|last13=Zhang|first13=Qunyuan|last14=Wendl|first14=Michael C.|last15=Lawrence|first15=Michael S.|last16=Larson|first16=David E.|last17=Chen|first17=Ken|last18=Dooling|first18=David J.|last19=Sabo|first19=Aniko|last20=Hawes|first20=Alicia C.|last21=Shen|first21=Hua|last22=Jhangiani|first22=Shalini N.|last23=Lewis|first23=Lora R.|last24=Hall|first24=Otis|last25=Zhu|first25=Yiming|last26=Mathew|first26=Tittu|last27=Ren|first27=Yanru|last28=Yao|first28=Jiqiang|last29=Scherer|first29=Steven E.|last30=Clerc|first30=Kerstin|display-authors=29|bibcode=2008Natur.455.1069D}}</ref><ref>{{cite journal|title=Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.|journal=Nature Communications|year=2018|volume=9|issue=1|pages=3787|doi=10.1038/s41467-018-06162-9|pmc=6141466|pmid=30224629|last1 = Wagner|first1 = Alex H.|last2 = Devarakonda|first2 = Siddhartha|last3 = Skidmore|first3 = Zachary L.|last4 = Krysiak|first4 = Kilannin|last5 = Ramu|first5 = Avinash|last6 = Trani|first6 = Lee|last7 = Kunisaki|first7 = Jason|last8 = Masood|first8 = Ashiq|last9 = Waqar|first9 = Saiama N.|last10 = Spies|first10 = Nicholas C.|last11 = Morgensztern|first11 = Daniel|last12 = Waligorski|first12 = Jason|last13 = Ponce|first13 = Jennifer|last14 = Fulton|first14 = Robert S.|last15 = Maggi|first15 = Leonard B.|last16 = Weber|first16 = Jason D.|last17 = Watson|first17 = Mark A.|last18 = o'Conor|first18 = Christopher J.|last19 = Ritter|first19 = Jon H.|last20 = Olsen|first20 = Rachelle R.|last21 = Cheng|first21 = Haixia|last22 = Mukhopadhyay|first22 = Anandaroop|last23 = Can|first23 = Ismail|last24 = Cessna|first24 = Melissa H.|last25 = Oliver|first25 = Trudy G.|last26 = Mardis|first26 = Elaine R.|last27 = Wilson|first27 = Richard K.|last28 = Griffith|first28 = Malachi|last29 = Griffith|first29 = Obi L.|last30 = Govindan|first30 = Ramaswamy|bibcode = 2018NatCo...9.3787W}}</ref> By better defining the landscape of germline and somatic alterations, this research helps drive new strategies for treating cancer, and is central to the concept of [[precision medicine]]. |
|||
Since joining Nationwide Children's Hospital in 2016, Dr. Mardis has turned the focus of her research to the incorporation of next-generation sequencing assays and established knowledge about cancer genomics into clinical and therapeutic decision-making, and into the design of new approaches to cancer immunotherapy.<ref name=":1"/><ref>{{cite journal|title=Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma|journal=Oncoimmunology|year=2019|volume=8|issue=4|page= e1561106|pmc=6422384|pmid=30906654|doi=10.1080/2162402x.2018.1561106|last1=Johanns|first1=Tanner M.|last2=Miller|first2=Christopher A.|last3=Liu|first3=Connor J.|last4=Perrin|first4=Richard J.|last5=Bender|first5=Diane|last6=Kobayashi|first6=Dale K.|last7=Campian|first7=Jian L.|last8=Chicoine|first8=Michael R.|last9=Dacey|first9=Ralph G.|last10=Huang|first10=Jiayi|last11=Fritsch|first11=Edward F.|last12=Gillanders|first12=William E.|last13=Artyomov|first13=Maxim N.|last14=Mardis|first14=Elaine R.|last15=Schreiber|first15=Robert D.|last16=Dunn|first16=Gavin P.}}</ref><ref>{{cite web|url=https://cancer.osu.edu/research-and-education/find-a-researcher/search-researcher-directory/elaine-r-mardis|title=Elaine R Mardis, PhD|publisher=Ohio State University|accessdate=May 1, 2019}}</ref> |
|||
In 2015, Mardis helped launch an open access, precision medicine journal, ''Molecular Case Studies'', in conjunction with Cold Spring Harbor Laboratory Press.<ref>{{cite press release|url=https://cshlpress.com/Molecular_Case_Studies_Press_Release_Cold_Spring_Harbor_Laboratory_Press.pdf|title=Press release. Cold Spring Harbor Laboratory Press.|accessdate=May 1, 2019}}</ref> She currently serves as Editor-in-Chief.<ref>{{cite web|url=http://molecularcasestudies.cshlp.org/site/misc/about.xhtml|title=About Cold Spring Harbor Molecular Case Studies|accessdate=May 1, 2019}}</ref> In 2020 she was Deputy Editor-in-Chief of ''[[Disease Models & Mechanisms]]'' journal, with [[Elizabeth Patton]] the Editor-in-Chief.<ref>{{Cite web|title=Editor biographies {{!}} Disease Models & Mechanisms {{!}} The Company of Biologists {{!}} Disease Models & Mechanisms {{!}} The Company of Biologists|url=https://journals.biologists.com/dmm/pages/editor-bios|access-date=2021-08-11|website=journals.biologists.com}}</ref> |
|||
Mardis was elected as president of the [[American Association for Cancer Research]] for 2019–2020.<ref>{{cite press release|url=https://www.nationwidechildrens.org/newsroom/news-releases/2018/03/elaine-r-mardis-phd-named-american-association-for-cancer-research-president-elect-2018-2019|title=Elaine R. Mardis, PhD, Named American Association for Cancer Research President-Elect 2018-2019|publisher=Nationwide Children's Hospital|date=March 21, 2012|accessdate=May 1, 2019}}</ref> |
|||
==Awards and honors== |
==Awards and honors== |
||
*2010: Scripps Translational Research Award<ref name=":1"/> |
|||
*[http://cas.ou.edu/2011-daa-and-dsa Distinguished Alumni Award, [[University of Oklahoma]], 2011] |
|||
*2011: Distinguished Alumna Award from the College of Arts and Sciences, Oklahoma University<ref>{{cite web|url=http://www.ou.edu/cas/alumni-and-friends/distinguished-alumni|title=Distinguished Alumni|publisher=Oklahoma University|accessdate=May 1, 2019}}</ref> |
|||
*[http://www.genomeweb.com/people-news-67 Scripps Genomic Medicine Award], [[The Scripps Research Institute|Scripps Research Institute]], 2010 |
|||
*2016: Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics from the American Association for Clinical Chemistry<ref>{{cite web|url=https://www.aacc.org/community/awards/the-morton-k,-d-,-schwartz-award-for-significant-contributions-in-cancer-research-diagnostics|title=The Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics|publisher=AACC|accessdate=May 1, 2019}}</ref> |
|||
*[http://genomebiology.com/about/edboard Editorial Board,] [[Genome Biology]] |
|||
*2017: Precision Medicine World Congress 2017 Luminary Award<ref>{{Cite web|url=https://2017duke.pmwcintl.com/awards/|title=PMWC Speaker biography: Awards|accessdate=May 1, 2019}}</ref> |
|||
*[http://genome.cshlp.org/site/misc/about.xhtml Editorial Board, Genome Research] |
|||
*2019: Elected to the 2019 class of Fellows of the American Association for Cancer Research (AACR) Academy<ref>{{Cite web|url=https://www.aacr.org/Newsroom/Pages/News-Release-Detail.aspx?ItemID=1284|title=American Association for Cancer Research Announces 2019 Class of Fellows of the AACR Academy|publisher=AACR|date=March 25, 2019|accessdate=May 1, 2019}}</ref> |
|||
*[http://www.facs.org/news/genome-acosog032610.html Chair, Basic and Translational Science Committee,] [[American College of Surgeons Oncology Group]] |
|||
==References== |
==References== |
||
{{Reflist}} |
|||
<references/> |
|||
==External links== |
==External links== |
||
{{Scholia|author}} |
|||
*[http://genome.wustl.edu/people/mardis_elaine |
*[https://web.archive.org/web/20100601232716/http://genome.wustl.edu/people/mardis_elaine McDonnell Institute Bio] |
||
*[ |
*[https://www.ncbi.nlm.nih.gov/pubmed?term=%22Mardis%20ER%22[Author] PubMed Citations] |
||
*[http://health.usnews.com/health-news/family-health/cancer/articles/2009/06/30/elaine-mardis-and-richard-wilson-taking-cancers-genetic-measure.html "Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure."] ''US News & World Report.'' 30 June 2009. |
*[http://health.usnews.com/health-news/family-health/cancer/articles/2009/06/30/elaine-mardis-and-richard-wilson-taking-cancers-genetic-measure.html "Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure."] ''US News & World Report.'' 30 June 2009. |
||
*[http://dmm.biologists.org/content/7/3/313 "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis."] Disease Models & Mechanisms 2014 7: 313-317; doi: 10.1242/dmm.015396 |
|||
*[http://www.technologyreview.com/biomedicine/25094/ "Genetic Clues to Cancer's Spread."] ''Technology Review.'' 14 April 2010. |
*[http://www.technologyreview.com/biomedicine/25094/ "Genetic Clues to Cancer's Spread."] ''Technology Review.'' 14 April 2010. |
||
*[http://www.genomeweb.com/sequencing/washington-university-team-sequences-aml-relapse-tumor "Washington University Team Sequences AML Relapse Tumor."] ''GenomeWeb Daily News.'' 12 May 2010. |
*[http://www.genomeweb.com/sequencing/washington-university-team-sequences-aml-relapse-tumor "Washington University Team Sequences AML Relapse Tumor."] ''GenomeWeb Daily News.'' 12 May 2010. |
||
*[http://www.nature.com/nature/podcast/v464/n7291/nature-2010-04-15.html ''Nature'' Podcast.] 15 April 2010. |
*[http://www.nature.com/nature/podcast/v464/n7291/nature-2010-04-15.html ''Nature'' Podcast.] 15 April 2010. |
||
*[http://www.cancer.gov/ncicancerbulletin/012610/page5 "A Conversation about Sequencing Cancer Genomes with Dr. Elaine Mardis."] ''NCI Cancer Bulletin''. 26 January 2010. |
*[http://www.cancer.gov/ncicancerbulletin/012610/page5 "A Conversation about Sequencing Cancer Genomes with Dr. Elaine Mardis."] {{Webarchive|url=https://web.archive.org/web/20100824025434/http://www.cancer.gov/ncicancerbulletin/012610/page5 |date=2010-08-24 }} ''NCI Cancer Bulletin''. 26 January 2010. |
||
{{Authority control |
{{Authority control}} |
||
{{Persondata <!-- Metadata: see [[Wikipedia:Persondata]]. --> |
|||
| NAME =Mardis, Elaine |
|||
| ALTERNATIVE NAMES = |
|||
| SHORT DESCRIPTION = |
|||
| DATE OF BIRTH =28 September 1962 |
|||
| PLACE OF BIRTH = |
|||
| DATE OF DEATH = |
|||
| PLACE OF DEATH = |
|||
⚫ | |||
{{DEFAULTSORT:Mardis, Elaine}} |
{{DEFAULTSORT:Mardis, Elaine}} |
||
[[Category:1962 births]] |
[[Category:1962 births]] |
||
[[Category:Cancer genomics]] |
|||
[[Category:Human Genome Project scientists]] |
|||
[[Category:Living people]] |
[[Category:Living people]] |
||
[[Category:American geneticists]] |
[[Category:American geneticists]] |
||
[[Category: |
[[Category:University of Oklahoma alumni]] |
||
[[Category:Members of the National Academy of Medicine]] |
|||
[[Category:Washington University School of Medicine faculty]] |
|||
[[Category:Ohio State University faculty]] |
Latest revision as of 21:36, 9 February 2024
Elaine Mardis | |
---|---|
Alma mater | University of Oklahoma |
Scientific career | |
Institutions | McDonnell Genome Institute Washington University School of Medicine Bio-Rad Laboratories |
Elaine R. Mardis (born September 28, 1962) is the co-executive director of the Institute for Genomic Medicine at Nationwide Children's Hospital, where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine.[1] She also is professor of pediatrics at the Ohio State University College of Medicine.[2] Mardis’s research focuses on the genomic characterization of cancer and its implications for cancer medicine.[3] She was part of the team that reported the first next-generation-based sequencing of a whole cancer genome,[4][5] and participated extensively in The Cancer Genome Atlas (TCGA) and the Pediatric Cancer Genome Project (PCGP).[3][6][7][8]
Biography
[edit]Mardis was born in North Platte, Nebraska. She gained a passion for science at an early age, and credits her father, a chemistry professor for more than 30 years, for nurturing this passion.[9][10]
She received her undergraduate degree in Zoology from the University of Oklahoma in 1984.[1] During her senior year she took a course in biochemistry that was taught by Bruce Roe, PhD, which says opened her eyes to the world of molecular biology.[9] She stayed at the University of Oklahoma for her doctoral studies under the supervision of Dr. Roe, who was one of the first academic scientists to have a fluorescent DNA sequencer in the laboratory.[10] As a result, during her doctoral work Mardis learned the art of DNA sequencing, at a time when few others were doing this.[9][10]
After obtaining her PhD in chemistry and biochemistry in 1989, Mardis did postgraduate work in industry at Bio-Rad Laboratories in Hercules, California.[1]
In 1993, Mardis joined the faculty of Washington University School of Medicine.[1] Over the next 23 years, she held several and academic and leadership roles at the University, including serving as co-director of the McDonnell Genome Institute.[3] In that position, she contributed substantially to the sequencing and analysis of the human genome,[11] and was instrumental in establishing the utility of massively parallel sequencing technologies for understanding cancer biology.[3] Her work in cancer genetics and genomics has provided insights into the genetic drivers of many types of cancer, including acute myeloid leukemia,[7][12][13] breast cancer,[14][15] glioblastoma,[16] and lung adenocarcinoma.[17][18] By better defining the landscape of germline and somatic alterations, this research helps drive new strategies for treating cancer, and is central to the concept of precision medicine.
Since joining Nationwide Children's Hospital in 2016, Dr. Mardis has turned the focus of her research to the incorporation of next-generation sequencing assays and established knowledge about cancer genomics into clinical and therapeutic decision-making, and into the design of new approaches to cancer immunotherapy.[3][19][20]
In 2015, Mardis helped launch an open access, precision medicine journal, Molecular Case Studies, in conjunction with Cold Spring Harbor Laboratory Press.[21] She currently serves as Editor-in-Chief.[22] In 2020 she was Deputy Editor-in-Chief of Disease Models & Mechanisms journal, with Elizabeth Patton the Editor-in-Chief.[23]
Mardis was elected as president of the American Association for Cancer Research for 2019–2020.[24]
Awards and honors
[edit]- 2010: Scripps Translational Research Award[3]
- 2011: Distinguished Alumna Award from the College of Arts and Sciences, Oklahoma University[25]
- 2016: Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics from the American Association for Clinical Chemistry[26]
- 2017: Precision Medicine World Congress 2017 Luminary Award[27]
- 2019: Elected to the 2019 class of Fellows of the American Association for Cancer Research (AACR) Academy[28]
References
[edit]- ^ a b c d "Nationwide Children's Hospital: Find a Doctor". Retrieved May 1, 2019.
- ^ "The Lantern". 26 June 2018. Retrieved May 1, 2019.
- ^ a b c d e f "PMWC Speaker Biography". Retrieved May 1, 2019.
- ^ Ley, Timothy J.; Mardis, Elaine R.; Ding, Li; Fulton, Bob; McLellan, Michael D.; Chen, Ken; Dooling, David; Dunford-Shore, Brian H.; McGrath, Sean; Hickenbotham, Matthew; Cook, Lisa; Abbott, Rachel; Larson, David E.; Koboldt, Dan C.; Pohl, Craig; Smith, Scott; Hawkins, Amy; Abbott, Scott; Locke, Devin; Hillier, Ladeana W.; Miner, Tracie; Fulton, Lucinda; Magrini, Vincent; Wylie, Todd; Glasscock, Jarret; Conyers, Joshua; Sander, Nathan; Shi, Xiaoqi; Osborne, John R.; et al. (2008). "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome". Nature. 456 (7218): 66–72. Bibcode:2008Natur.456...66L. doi:10.1038/nature07485. PMC 2603574. PMID 18987736.
- ^ Grady, Denise (November 6, 2008). ""Scientists Decode Set of Cancer Genes." New York Times, November 5, 2008". The New York Times. Retrieved May 1, 2019.
- ^ "The Cancer Genome Atlas Timeline & Milestones". National Cancer Institute. 2018-06-13. Retrieved May 1, 2019.
- ^ a b Cancer Genome Atlas Research Network; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; m. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman; Aldape, Ken; Alfred Yung, W. K.; Bogler, Oliver; Vandenberg, Scott; Berger, Mitchel; Prados, Michael; Muzny, Donna; Morgan, Margaret; Scherer, Steve; Sabo, Aniko; Nazareth, Lynn; Lewis, Lora; Hall, Otis; Zhu, Yiming; Ren, Yanru; Alvi, Omar; Yao, Jiqiang; Hawes, Alicia; Jhangiani, Shalini; Fowler, Gerald; et al. (2008). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–1068. Bibcode:2008Natur.455.1061M. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
- ^ Zhang, J.; Wu, G.; Miller, C. P.; Tatevossian, R. G.; Dalton, J. D.; Tang, B.; Orisme, W.; Punchihewa, C.; Parker, M.; Qaddoumi, I.; Boop, F. A.; Lu, C.; Kandoth, C.; Ding, L.; Lee, R.; Huether, R.; Chen, X.; Hedlund, E.; Nagahawatte, P.; Rusch, M.; Boggs, K.; Cheng, J.; Becksfort, J.; Ma, J.; Song, G.; Li, Y.; Wei, L.; Wang, J.; Shurtleff, S.; et al. (2013). "Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas". Nature Genetics. 45 (6): 602–612. doi:10.1038/ng.2611. PMC 3727232. PMID 23583981.
- ^ a b c Mardis, E.; Dhillon, P. (2014). "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis". Disease Models & Mechanisms. 7 (3): 313–317. doi:10.1242/dmm.015396. PMC 3944491. PMID 24609032.
- ^ a b c Arbanas, Caroline (September 10, 2008). "Genome technology wizard". The Source, Washington University in St. Louis. Retrieved May 1, 2019.
- ^ Purddy, Michael C. (October 21, 2004). "Genome center is major contributor to 'finished' human genome sequence". Washington University in St. Louis. Retrieved May 1, 2019.
- ^ Mardis, Elaine R.; Ding, Li; Dooling, David J.; Larson, David E.; McLellan, Michael D.; Chen, Ken; Koboldt, Daniel C.; Fulton, Robert S.; Delehaunty, Kim D.; McGrath, Sean D.; Fulton, Lucinda A.; Locke, Devin P.; Magrini, Vincent J.; Abbott, Rachel M.; Vickery, Tammi L.; Reed, Jerry S.; Robinson, Jody S.; Wylie, Todd; Smith, Scott M.; Carmichael, Lynn; Eldred, James M.; Harris, Christopher C.; Walker, Jason; Peck, Joshua B.; Du, Feiyu; Dukes, Adam F.; Sanderson, Gabriel E.; Brummett, Anthony M.; Clark, Eric; et al. (2009). "Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome". The New England Journal of Medicine. 361 (11): 1058–1066. doi:10.1056/NEJMoa0903840. PMC 3201812. PMID 19657110.
- ^ Ding, Li; Ley, Timothy J.; Larson, David E.; Miller, Christopher A.; Koboldt, Daniel C.; Welch, John S.; Ritchey, Julie K.; Young, Margaret A.; Lamprecht, Tamara; McLellan, Michael D.; McMichael, Joshua F.; Wallis, John W.; Lu, Charles; Shen, Dong; Harris, Christopher C.; Dooling, David J.; Fulton, Robert S.; Fulton, Lucinda L.; Chen, Ken; Schmidt, Heather; Kalicki-Veizer, Joelle; Magrini, Vincent J.; Cook, Lisa; McGrath, Sean D.; Vickery, Tammi L.; Wendl, Michael C.; Heath, Sharon; Watson, Mark A.; Link, Daniel C.; et al. (2012). "Clonal evolution in relapsed acute myeloid leukemia revealed by whole-genome sequencing". Nature. 481 (7382): 506–10. Bibcode:2012Natur.481..506D. doi:10.1038/nature10738. PMC 3267864. PMID 22237025.
- ^ Ellis, Matthew J.; Ding, Li; Shen, Dong; Luo, Jingqin; Suman, Vera J.; Wallis, John W.; Van Tine, Brian A.; Hoog, Jeremy; Goiffon, Reece J.; Goldstein, Theodore C.; Ng, Sam; Lin, Li; Crowder, Robert; Snider, Jacqueline; Ballman, Karla; Weber, Jason; Chen, Ken; Koboldt, Daniel C.; Kandoth, Cyriac; Schierding, William S.; McMichael, Joshua F.; Miller, Christopher A.; Lu, Charles; Harris, Christopher C.; McLellan, Michael D.; Wendl, Michael C.; Deschryver, Katherine; Allred, D. Craig; Esserman, Laura; et al. (2012). "Whole-genome analysis informs breast cancer response to aromatase inhibition". Nature. 486 (7403): 353–60. Bibcode:2012Natur.486..353E. doi:10.1038/nature11143. PMC 3383766. PMID 22722193.
- ^ Griffith, Obi L.; Spies, Nicholas C.; Anurag, Meenakshi; Griffith, Malachi; Luo, Jingqin; Tu, Dongsheng; Yeo, Belinda; Kunisaki, Jason; Miller, Christopher A.; Krysiak, Kilannin; Hundal, Jasreet; Ainscough, Benjamin J.; Skidmore, Zachary L.; Campbell, Katie; Kumar, Runjun; Fronick, Catrina; Cook, Lisa; Snider, Jacqueline E.; Davies, Sherri; Kavuri, Shyam M.; Chang, Eric C.; Magrini, Vincent; Larson, David E.; Fulton, Robert S.; Liu, Shuzhen; Leung, Samuel; Voduc, David; Bose, Ron; Dowsett, Mitch; et al. (2018). "The prognostic effects of somatic mutations in ER-positive breast cancer". Nature Communications. 9 (1): 3476. Bibcode:2018NatCo...9.3476G. doi:10.1038/s41467-018-05914-x. PMC 6123466. PMID 30181556.
- ^ McLendon, Roger; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; m. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman; Aldape, Ken; Alfred Yung, W. K.; Bogler, Oliver; Vandenberg, Scott; Berger, Mitchel; Prados, Michael; Muzny, Donna; Morgan, Margaret; Scherer, Steve; Sabo, Aniko; Nazareth, Lynn; Lewis, Lora; Hall, Otis; Zhu, Yiming; Ren, Yanru; Alvi, Omar; Yao, Jiqiang; Hawes, Alicia; Jhangiani, Shalini; Fowler, Gerald; et al. (2008). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–8. Bibcode:2008Natur.455.1061M. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
- ^ Ding, Li; Getz, Gad; Wheeler, David A.; Mardis, Elaine R.; McLellan, Michael D.; Cibulskis, Kristian; Sougnez, Carrie; Greulich, Heidi; Muzny, Donna M.; Morgan, Margaret B.; Fulton, Lucinda; Fulton, Robert S.; Zhang, Qunyuan; Wendl, Michael C.; Lawrence, Michael S.; Larson, David E.; Chen, Ken; Dooling, David J.; Sabo, Aniko; Hawes, Alicia C.; Shen, Hua; Jhangiani, Shalini N.; Lewis, Lora R.; Hall, Otis; Zhu, Yiming; Mathew, Tittu; Ren, Yanru; Yao, Jiqiang; Scherer, Steven E.; et al. (2008). "Somatic mutations affect key pathways in lung adenocarcinoma". Nature. 455 (7216): 1069–75. Bibcode:2008Natur.455.1069D. doi:10.1038/nature07423. PMC 2694412. PMID 18948947.
- ^ Wagner, Alex H.; Devarakonda, Siddhartha; Skidmore, Zachary L.; Krysiak, Kilannin; Ramu, Avinash; Trani, Lee; Kunisaki, Jason; Masood, Ashiq; Waqar, Saiama N.; Spies, Nicholas C.; Morgensztern, Daniel; Waligorski, Jason; Ponce, Jennifer; Fulton, Robert S.; Maggi, Leonard B.; Weber, Jason D.; Watson, Mark A.; o'Conor, Christopher J.; Ritter, Jon H.; Olsen, Rachelle R.; Cheng, Haixia; Mukhopadhyay, Anandaroop; Can, Ismail; Cessna, Melissa H.; Oliver, Trudy G.; Mardis, Elaine R.; Wilson, Richard K.; Griffith, Malachi; Griffith, Obi L.; Govindan, Ramaswamy (2018). "Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer". Nature Communications. 9 (1): 3787. Bibcode:2018NatCo...9.3787W. doi:10.1038/s41467-018-06162-9. PMC 6141466. PMID 30224629.
- ^ Johanns, Tanner M.; Miller, Christopher A.; Liu, Connor J.; Perrin, Richard J.; Bender, Diane; Kobayashi, Dale K.; Campian, Jian L.; Chicoine, Michael R.; Dacey, Ralph G.; Huang, Jiayi; Fritsch, Edward F.; Gillanders, William E.; Artyomov, Maxim N.; Mardis, Elaine R.; Schreiber, Robert D.; Dunn, Gavin P. (2019). "Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma". Oncoimmunology. 8 (4): e1561106. doi:10.1080/2162402x.2018.1561106. PMC 6422384. PMID 30906654.
- ^ "Elaine R Mardis, PhD". Ohio State University. Retrieved May 1, 2019.
- ^ "Press release. Cold Spring Harbor Laboratory Press" (PDF) (Press release). Retrieved May 1, 2019.
- ^ "About Cold Spring Harbor Molecular Case Studies". Retrieved May 1, 2019.
- ^ "Editor biographies | Disease Models & Mechanisms | The Company of Biologists | Disease Models & Mechanisms | The Company of Biologists". journals.biologists.com. Retrieved 2021-08-11.
- ^ "Elaine R. Mardis, PhD, Named American Association for Cancer Research President-Elect 2018-2019" (Press release). Nationwide Children's Hospital. March 21, 2012. Retrieved May 1, 2019.
- ^ "Distinguished Alumni". Oklahoma University. Retrieved May 1, 2019.
- ^ "The Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics". AACC. Retrieved May 1, 2019.
- ^ "PMWC Speaker biography: Awards". Retrieved May 1, 2019.
- ^ "American Association for Cancer Research Announces 2019 Class of Fellows of the AACR Academy". AACR. March 25, 2019. Retrieved May 1, 2019.
External links
[edit]- McDonnell Institute Bio
- [Author] PubMed Citations
- "Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure." US News & World Report. 30 June 2009.
- "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis." Disease Models & Mechanisms 2014 7: 313-317; doi: 10.1242/dmm.015396
- "Genetic Clues to Cancer's Spread." Technology Review. 14 April 2010.
- "Washington University Team Sequences AML Relapse Tumor." GenomeWeb Daily News. 12 May 2010.
- Nature Podcast. 15 April 2010.
- "A Conversation about Sequencing Cancer Genomes with Dr. Elaine Mardis." Archived 2010-08-24 at the Wayback Machine NCI Cancer Bulletin. 26 January 2010.