Artesunate/pyronaridine: Difference between revisions
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{{Short description|Combination medication for the treatment of malaria}} |
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| CAS_number = 884661-13-6 |
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'''Artesunate/pyronaridine''', sold under the brand name '''Pyramax''', is a [[fixed-dose combination]] medication for the treatment of [[malaria]].<ref name=WHO21st/><ref name=WHO2010/> It can be used for malaria of both the ''[[P. falciparum]]'' and ''[[P. vivax]]'' types.<ref name=WHO2010/> It combines [[artesunate]] and [[pyronaridine]].<ref name=WHO21st/> It is taken by mouth.<ref name=EMA2017>{{cite web|title=Pyramax 180 mg/60 mg Film-coated tablet|url=http://www.ema.europa.eu/docs/en_GB/document_library/Medicine_for_use_outside_EU/2012/06/WC500129288.pdf|website=EMA|access-date=13 December 2017}}</ref> |
'''Artesunate/pyronaridine''', sold under the brand name '''Pyramax''', is a [[fixed-dose combination]] medication for the treatment of [[malaria]].<ref name=WHO21st/><ref name=WHO2010/> It can be used for malaria of both the ''[[P. falciparum]]'' and ''[[P. vivax]]'' types.<ref name=WHO2010/> It combines [[artesunate]] and [[pyronaridine]].<ref name=WHO21st/> It is taken by mouth.<ref name=EMA2017>{{cite web|title=Pyramax 180 mg/60 mg Film-coated tablet|url=http://www.ema.europa.eu/docs/en_GB/document_library/Medicine_for_use_outside_EU/2012/06/WC500129288.pdf|website=EMA|access-date=13 December 2017|archive-date=14 December 2017|archive-url=https://web.archive.org/web/20171214014547/http://www.ema.europa.eu/docs/en_GB/document_library/Medicine_for_use_outside_EU/2012/06/WC500129288.pdf|url-status=dead}}</ref> |
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It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO21st">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 21st list 2019 | year = 2019 | hdl = 10665/325771 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access=free }}</ref> |
It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO21st">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 21st list 2019 | year = 2019 | hdl = 10665/325771 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access=free }}</ref> |
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==Medical uses== |
== Medical uses == |
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Artesunate/pyronaridine is used for [[malaria]] of both the ''[[P. falciparum]]'' and ''[[P. vivax]]'' types.<ref name=WHO2010/> It is not recommended for severe disease.<ref name=EMA2017/> |
Artesunate/pyronaridine is used for [[malaria]] of both the ''[[P. falciparum]]'' and ''[[P. vivax]]'' types.<ref name=WHO2010/> It is not recommended for severe disease.<ref name=EMA2017/> |
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A 2019 review found that the combination compared well to [[artemether/lumefantrine]].<ref name= |
A 2019 review (updated in 2021) found that the combination compared well to [[artemether/lumefantrine]].<ref name=":0">{{cite journal | vauthors = Pryce J, Taylor M, Fox T, Hine P | title = Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria | journal = The Cochrane Database of Systematic Reviews | volume = 2022 | issue = 6 | pages = CD006404 | date = June 2022 | pmid = 35726133 | pmc = 9209011 | doi = 10.1002/14651858.CD006404.pub4 }}</ref> Benefits also appear similar to [[mefloquine]] together with [[artesunate]].<ref name=":0" /> It is not recommended for the prevention of malaria.<ref name=EMA2017/> |
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== Research for drug repurposing == |
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There is some ''[[in vitro]]'' evidence that suggests artesunate/pyronaridine may be worthy of clinical trial study to determine whether it might have a role as a drug for COVID-19 treatment.<ref>{{cite journal | vauthors = Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, Kamarulzaman A, Sall A, Kremsner P | display-authors = 6 | title = Repurposing Antimalarials to Tackle the COVID-19 Pandemic | journal = Trends in Parasitology | volume = 37 | issue = 1 | pages = 8–11 | date = January 2021 | pmid = 33153922 | pmc = 7572038 | doi = 10.1016/j.pt.2020.10.003 }}</ref> |
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== References == |
== References == |
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Latest revision as of 10:51, 24 October 2023
| Combination of | |
|---|---|
| Artesunate | Antimalarial |
| Pyronaridine | Antimalarial |
| Clinical data | |
| Trade names | Pyramax[1] |
| Other names | Artesunate/pyronaridine tetraphosphate[1] |
| Routes of administration | By mouth[2] |
| ATC code | |
| Identifiers | |
| CAS Number | |
Artesunate/pyronaridine, sold under the brand name Pyramax, is a fixed-dose combination medication for the treatment of malaria.[3][1] It can be used for malaria of both the P. falciparum and P. vivax types.[1] It combines artesunate and pyronaridine.[3] It is taken by mouth.[2]
The combination is generally well tolerated.[1] Side effects may include headache, vomiting, or cough.[1] Use in those with severe liver disease or kidney disease is not recommended.[2] Use is not generally recommended in early pregnancy.[2] However, there are no other options and if treatment may save the mother's life it may be used.[2] The two components work by different mechanisms.[2]
It is on the World Health Organization's List of Essential Medicines.[3]
Medical uses
[edit]Artesunate/pyronaridine is used for malaria of both the P. falciparum and P. vivax types.[1] It is not recommended for severe disease.[2]
A 2019 review (updated in 2021) found that the combination compared well to artemether/lumefantrine.[4] Benefits also appear similar to mefloquine together with artesunate.[4] It is not recommended for the prevention of malaria.[2]
Research for drug repurposing
[edit]There is some in vitro evidence that suggests artesunate/pyronaridine may be worthy of clinical trial study to determine whether it might have a role as a drug for COVID-19 treatment.[5]
References
[edit]- ^ a b c d e f g "Application for inclusion in the WHO Model List of essential medicines" (PDF). WHO. Nov 2010. Retrieved 29 June 2017.
- ^ a b c d e f g h "Pyramax 180 mg/60 mg Film-coated tablet" (PDF). EMA. Archived from the original (PDF) on 14 December 2017. Retrieved 13 December 2017.
- ^ a b c World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ a b Pryce J, Taylor M, Fox T, Hine P (June 2022). "Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria". The Cochrane Database of Systematic Reviews. 2022 (6): CD006404. doi:10.1002/14651858.CD006404.pub4. PMC 9209011. PMID 35726133.
- ^ Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, et al. (January 2021). "Repurposing Antimalarials to Tackle the COVID-19 Pandemic". Trends in Parasitology. 37 (1): 8–11. doi:10.1016/j.pt.2020.10.003. PMC 7572038. PMID 33153922.
