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Lasalocid: Difference between revisions

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{{Short description|Chemical compound}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| Verifiedfields = changed
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<!--Clinical data-->
<!--Clinical data-->
| tradename =
| tradename =
| Drugs.com = {{drugs.com|international|lasalocid}}
| Drugs.com = {{drugs.com|international|lasalocid}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| pregnancy_category =
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| legal_status =
| routes_of_administration =
| routes_of_administration =


<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability =
| bioavailability =
| protein_bound =
| protein_bound =
| metabolism =
| metabolism =
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =


<!--Identifiers-->
<!--Identifiers-->
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| ATCvet = yes
| ATCvet = yes
| ATC_prefix = P51
| ATC_prefix = P51
| ATC_suffix = AH02
| ATC_suffix = BB02
| PubChem = 5360807
| PubChem = 5360807
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| DrugBank =
| ChEBI = 92181
| ChEBI = 92181
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
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<!--Chemical data-->
<!--Chemical data-->
| chemical_formula =
| chemical_formula =
| C=34 | H=54 | O=8
| C=34 | H=54 | O=8
| smiles = O=C(O)c1c(O)c(ccc1CC[C@@H](C)[C@H](O)[C@@H](C(=O)[C@@H]([C@H]3O[C@@]([C@@H]2O[C@H]([C@](O)(CC2)CC)C)(CC)C[C@@H]3C)CC)C)C
| smiles = O=C(O)c1c(O)c(ccc1CC[C@@H](C)[C@H](O)[C@@H](C(=O)[C@@H]([C@H]3O[C@@]([C@@H]2O[C@H]([C@](O)(CC2)CC)C)(CC)C[C@@H]3C)CC)C)C
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'''Lasalocid''' is an antibacterial agent and a [[coccidiostat]], which is produced by strains of ''[[Streptomyces]] lasaliensis''. It is the drug in the feed additives called '''Bovatec''' and '''Avatec'''.<ref>[https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm064879.pdf FOIA Drug Summaries.]</ref>
'''Lasalocid''' is an antibacterial agent and a [[coccidiostat]], which is produced by strains of ''[[Streptomyces]] lasaliensis''. It is the drug in the feed additives called '''Bovatec''' and '''Avatec'''.<ref>[https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm064879.pdf FOIA Drug Summaries.]</ref>


Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase (including lipid bilayer membranes). It can also transport big organic cations like dopamine.{{cn}}
Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase (including lipid bilayer membranes). It can also transport big organic cations like dopamine.{{cn|date=December 2022}}


Horses and dogs<ref>[http://veterinaryrecord.bmj.com/content/155/6/174.abstract BMJ Veterinary Record]</ref> are very susceptible to the toxic effects of lasalocid, and it should never be administered to non-target species.
Horses and dogs<ref>[http://veterinaryrecord.bmj.com/content/155/6/174.abstract BMJ Veterinary Record]</ref> are very susceptible to the toxic effects of lasalocid, and it should never be administered to non-target species.

Latest revision as of 01:08, 11 October 2023

Lasalocid
Clinical data
AHFS/Drugs.comInternational Drug Names
ATCvet code
Identifiers
  • 6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.043.077 Edit this at Wikidata
Chemical and physical data
FormulaC34H54O8
Molar mass590.798 g·mol−1
3D model (JSmol)
  • O=C(O)c1c(O)c(ccc1CC[C@@H](C)[C@H](O)[C@@H](C(=O)[C@@H]([C@H]3O[C@@]([C@@H]2O[C@H]([C@](O)(CC2)CC)C)(CC)C[C@@H]3C)CC)C)C
  • InChI=1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+/m1/s1 checkY
  • Key:BBMULGJBVDDDNI-OWKLGTHSSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. It is the drug in the feed additives called Bovatec and Avatec.[1]

Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase (including lipid bilayer membranes). It can also transport big organic cations like dopamine.[citation needed]

Horses and dogs[2] are very susceptible to the toxic effects of lasalocid, and it should never be administered to non-target species.

References

[edit]
  1. ^ FOIA Drug Summaries.
  2. ^ BMJ Veterinary Record


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