Lines of Zahn: Difference between revisions
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{{Short description|Tissue damage caused by thrombosis}} |
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'''Lines of Zahn''' are a characteristic of [[thrombus|thrombi]]<ref name="urlAtherosclerosis">{{cite web |url=http://library.med.utah.edu/WebPath/ATHHTML/ATH031.html |title=Atherosclerosis |work= |accessdate=}}</ref> that appear particularly when formed in the [[heart]] or [[aorta]]. They have visible and microscopic alternating layers (laminations) of [[platelets]] mixed with [[fibrin]], which appear lighter and darker layers of [[red blood cell]]s.<ref name="Lee">{{cite journal|vauthors=Lee R, Adlam D, Clelland CA, Channon KM | title=Lines of Zahn in coronary artery thrombus | journal=Eur Heart J | year= 2012 | volume= 33| issue= 9| pages= 1039| pmid=22345124 | doi=10.1093/eurheartj/ehs028}}</ref> Their presence implies thrombosis at a site of rapid [[blood flow]] that happened before death. In veins or smaller arteries, where flow is not as constant, they are less apparent. |
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{{Infobox medical condition (new) |
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| name = Lines of Zahn |
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| image = Pulmonary thromboembolus, recent (3626658803).jpg |
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| specialty = [[Pathology]] |
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| causes = [[Thrombosis]] |
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}} |
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'''Lines of Zahn''' are a characteristic of [[thrombus|thrombi]]. They have layers, with lighter layers of [[Platelet|platelets]] and [[fibrin]], and darker layers of [[Red blood cell|red blood cells]]. They are more present on thrombi formed with faster blood flow, more so on thrombi from the [[heart]] and [[aorta]]. They are only seen on thrombi formed before death. They are named after German–Swiss pathologist [[Friedrich Wilhelm Zahn]]. |
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== Definition == |
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Lines of Zahn are a characteristic of [[thrombus|thrombi]].<ref name=":0">{{Cite book|chapter-url=https://www.sciencedirect.com/science/article/pii/B9780120777501500155|title=Thrombosis and Bleeding Disorders - Theory and Methods|publisher=[[Academic Press]]|year=1971|isbn=978-0-12-077750-1|pages=488–534|language=en|chapter=11 - Thrombosis|doi=10.1016/B978-0-12-077750-1.50015-5}}</ref> They have visible and microscopic alternating layers (laminations).<ref name="Lee">{{cite journal | vauthors = Lee R, Adlam D, Clelland CA, Channon KM | title = Lines of Zahn in coronary artery thrombus | journal = European Heart Journal | volume = 33 | issue = 9 | pages = 1039 | date = May 2012 | pmid = 22345124 | doi = 10.1093/eurheartj/ehs028 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Saha P, Humphries J, Modarai B, Mattock K, Waltham M, Evans CE, Ahmad A, Patel AS, Premaratne S, Lyons OT, Smith A | display-authors = 6 | title = Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions | journal = Arteriosclerosis, Thrombosis, and Vascular Biology | volume = 31 | issue = 3 | pages = 506–512 | date = March 2011 | pmid = 21325673 | pmc = 3079895 | doi = 10.1161/ATVBAHA.110.213405 }}</ref> [[Platelets]] mixed with [[fibrin]] form lighter layers.<ref name="Lee" /> [[Red blood cell|Red blood cells]] form darker layers.<ref name="Lee" /> Sometimes, the term "lines of Zahn" only refers to the lighter layers.<ref>{{cite journal | vauthors = Stone J, Hangge P, Albadawi H, Wallace A, Shamoun F, Knuttien MG, Naidu S, Oklu R | display-authors = 6 | title = Deep vein thrombosis: pathogenesis, diagnosis, and medical management | journal = Cardiovascular Diagnosis and Therapy | volume = 7 | issue = Suppl 3 | pages = S276–S284 | date = December 2017 | pmid = 29399531 | pmc = 5778510 | doi = 10.21037/cdt.2017.09.01 | doi-access = free }}</ref> |
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== Evaluation == |
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Lines of Zahn can be used to confirm diagnosis of a thrombus.<ref name=":0" /> Their presence implies thrombosis at a site of rapid [[blood flow]] that happened before death. They are more common in thrombi formed in the [[heart]] or [[aorta]].<ref name=":1">{{cite journal | vauthors = Heo JH, Nam HS, Kim YD, Choi JK, Kim BM, Kim DJ, Kwon I | title = Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke | journal = Journal of Stroke | volume = 22 | issue = 1 | pages = 64–75 | date = January 2020 | pmid = 32027792 | pmc = 7005358 | doi = 10.5853/jos.2019.03440 }}</ref> In veins or smaller arteries, where flow is not as constant, they occur less frequently.<ref name=":1" /> They are also only seen on thrombi formed when blood is flowing. This is a distinguishing marker between thrombi that formed before death and after death.{{cn|date=February 2021}} |
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== History == |
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Lines of Zahn are only seen when thrombi is formed in flowing blood as it is a distinguishing marker between ante-mortem and postmortem thrombi formation. |
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== Additional images == |
== Additional images == |
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<gallery> |
<gallery> |
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File:Histopathology showing lines of Zahn in a thrombus.jpg|Thrombus showing circumferential lines of Zahn. |
File:Histopathology showing lines of Zahn in a thrombus.jpg|Thrombus showing circumferential lines of Zahn. |
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File:Laminations in a thrombus - |
File:Laminations in a thrombus - intermed mag.jpg|Intermediate magnification [[micrograph]] showing laminations in a thrombus in a fatal [[pulmonary embolism]]. [[H&E stain]]. |
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File:Laminations in a thrombus - |
File:Laminations in a thrombus - high mag.jpg|High magnification [[micrograph]] showing laminations in a thrombus in a fatal [[pulmonary embolism]]. [[H&E stain]]. |
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</gallery> |
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==References== |
== References == |
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{{reflist}} |
{{reflist}} |
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==Further reading== |
== Further reading == |
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{{refbegin}} |
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* Kumar, V. et al. (2005). Hemodynamic Disorders, Thromboembolic Disease, and Shock. ''Robbins and Cotran Pathologic Basis of Disease. 7th edition.'' Elsevier Saunders: Pennsylvania. |
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* {{cite book | vauthors = Kumar V, Abbas AK, Fausto N |title=Robbins & Cotran Pathologic Basis of Disease |date=2005 | edition = 7th | location = Pennsylvania |publisher=Elsevier/Saunders |isbn=978-0-7216-0187-8}} |
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* {{cite book|title=Underwood's pathology : a clinical approach|publisher=Churchill Livingstone|location=Edinburgh|isbn= |
* {{cite book|title=Underwood's pathology : a clinical approach|publisher=Churchill Livingstone|location=Edinburgh|isbn=978-0-7020-4672-8 |url= http://cune3.tripod.com/pathology/underwood/under06.pdf| edition=6th | veditors = Cross SS |chapter=Chapter 6: Thrombosis, Embolism and Infarction|year=2013}} |
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{{refend}} |
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{{Cardiovascular system symptoms and signs}} |
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{{Eponymous medical signs for circulatory and respiratory systems}} |
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[[Category:Symptoms and signs: Vascular]] |
[[Category:Symptoms and signs: Vascular]] |
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{{med-sign-stub}} |
Latest revision as of 20:55, 16 September 2023
Lines of Zahn | |
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A recent pulmonary thrombo-embolus with prominent lines of Zahn. The pale areas consist of fibrin and platelets. The red areas consist of erythrocytes. | |
Specialty | Pathology |
Causes | Thrombosis |
Lines of Zahn are a characteristic of thrombi. They have layers, with lighter layers of platelets and fibrin, and darker layers of red blood cells. They are more present on thrombi formed with faster blood flow, more so on thrombi from the heart and aorta. They are only seen on thrombi formed before death. They are named after German–Swiss pathologist Friedrich Wilhelm Zahn.
Definition
[edit]Lines of Zahn are a characteristic of thrombi.[1] They have visible and microscopic alternating layers (laminations).[2][3] Platelets mixed with fibrin form lighter layers.[2] Red blood cells form darker layers.[2] Sometimes, the term "lines of Zahn" only refers to the lighter layers.[4]
Evaluation
[edit]Lines of Zahn can be used to confirm diagnosis of a thrombus.[1] Their presence implies thrombosis at a site of rapid blood flow that happened before death. They are more common in thrombi formed in the heart or aorta.[5] In veins or smaller arteries, where flow is not as constant, they occur less frequently.[5] They are also only seen on thrombi formed when blood is flowing. This is a distinguishing marker between thrombi that formed before death and after death.[citation needed]
History
[edit]Lines of Zahn are named after German–Swiss pathologist Friedrich Wilhelm Zahn.[6]
Additional images
[edit]-
Thrombus showing circumferential lines of Zahn.
-
Low magnification micrograph showing laminations in a thrombus in a fatal pulmonary embolism. H&E stain.
-
Intermediate magnification micrograph showing laminations in a thrombus in a fatal pulmonary embolism. H&E stain.
-
High magnification micrograph showing laminations in a thrombus in a fatal pulmonary embolism. H&E stain.
References
[edit]- ^ a b "11 - Thrombosis". Thrombosis and Bleeding Disorders - Theory and Methods. Academic Press. 1971. pp. 488–534. doi:10.1016/B978-0-12-077750-1.50015-5. ISBN 978-0-12-077750-1.
- ^ a b c Lee R, Adlam D, Clelland CA, Channon KM (May 2012). "Lines of Zahn in coronary artery thrombus". European Heart Journal. 33 (9): 1039. doi:10.1093/eurheartj/ehs028. PMID 22345124.
- ^ Saha P, Humphries J, Modarai B, Mattock K, Waltham M, Evans CE, et al. (March 2011). "Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions". Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (3): 506–512. doi:10.1161/ATVBAHA.110.213405. PMC 3079895. PMID 21325673.
- ^ Stone J, Hangge P, Albadawi H, Wallace A, Shamoun F, Knuttien MG, et al. (December 2017). "Deep vein thrombosis: pathogenesis, diagnosis, and medical management". Cardiovascular Diagnosis and Therapy. 7 (Suppl 3): S276–S284. doi:10.21037/cdt.2017.09.01. PMC 5778510. PMID 29399531.
- ^ a b Heo JH, Nam HS, Kim YD, Choi JK, Kim BM, Kim DJ, Kwon I (January 2020). "Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke". Journal of Stroke. 22 (1): 64–75. doi:10.5853/jos.2019.03440. PMC 7005358. PMID 32027792.
- ^ Stegman JK, ed. (2006), Stedman's Medical Dictionary (28th ed.), Baltimore, MD: Lippincott, Williams, & Wilkins
Further reading
[edit]- Kumar V, Abbas AK, Fausto N (2005). Robbins & Cotran Pathologic Basis of Disease (7th ed.). Pennsylvania: Elsevier/Saunders. ISBN 978-0-7216-0187-8.
- Cross SS, ed. (2013). "Chapter 6: Thrombosis, Embolism and Infarction". Underwood's pathology : a clinical approach (PDF) (6th ed.). Edinburgh: Churchill Livingstone. ISBN 978-0-7020-4672-8.