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{{Short description|Muscle relaxant}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
⚫
| verifiedrevid = 444349980
| Watchedfields = changed
⚫
| verifiedrevid = 447821122
| IUPAC_name = 5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
| IUPAC_name = 5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
| image = Mephenoxalone.svg
| image = Mephenoxalone.svg


<!--Clinical data-->
<!--Clinical data-->
| tradename =
| tradename = Dorsiflex, Moderamin, Control-OM
| Drugs.com = {{drugs.com|international|mephenoxalone}}
| Drugs.com = {{drugs.com|international|mephenoxalone}}
| pregnancy_category =
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_BR = C1
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-03-31 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=2023-08-03 |access-date=2023-08-16 |publisher=[[Diário Oficial da União]] |language=pt-BR |publication-date=2023-04-04}}</ref>
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_NZ = <!-- Class A, B, C -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_EU =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_status =
| legal_status =
| routes_of_administration =
| routes_of_administration =


<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
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| metabolism =
| metabolism =
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =


<!--Identifiers-->
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 70-07-5
| CAS_number = 70-07-5
| ATC_prefix = N05
| ATC_prefix = N05
| ATC_suffix = BX01
| ATC_suffix = BX01
| PubChem = 6257
| PubChem = 6257
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 2104790
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = CZ87T54W8W
| UNII = CZ87T54W8W
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07318
| KEGG = D07318
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 6021


<!--Chemical data-->
<!--Chemical data-->
| C=11 | H=13 | N=1 | O=4
| C=11 | H=13 | N=1 | O=4
| smiles = O=C2OC(COc1c(OC)cccc1)CN2
| molecular_weight = 223.225 g/mol
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = ZMNSRFNUONFLSP-UHFFFAOYSA-N
}}
}}


'''Mephenoxalone''' ('''Dorsiflex''', '''Moderamin''' '''Control-OM''') is a [[muscle relaxant]] and mild [[anxiolytic]]. It inhibits neuron transmission, that will produce skeletal muscle relaxation by inhibits the reflex arc of skeletal muscle. As the effect of muscle relaxation, mephenoxalone affects mental condition and also a treatment for nervousness and anxiety.
'''Mephenoxalone''' (trade names '''Dorsiflex''', '''Moderamin''', '''Control-OM''') is a [[muscle relaxant]]<ref>{{cite journal | vauthors = Magnenat M | title = [The utilization in psychotherapy of a tensiolytic agent with muscle relaxant effect, Control OM (mephenoxalone), alone or associated with thymoleptics] | journal = Therapeutische Umschau. Revue Therapeutique | volume = 18 | pages = 516–20 | date = December 1961 | pmid = 14468333 }}</ref> and mild [[anxiolytic]].<ref>[[Monthly Index of Medical Specialities|MIMS]]: [http://www.mims.com/USA/drug/info/mephenoxalone/ Mephenoxalone]</ref> It inhibits neuron transmission, relaxing skeletal muscles by inhibiting the [[reflex arc]].{{citation needed|date=December 2013}} As the effect of muscle relaxation, mephenoxalone affects mental condition, and is also a treatment for nervousness and [[anxiety]].

== See also ==
* [[Chlorphenesin]]
* [[Guaifenesin]]
* [[Mephenesin]]
* [[Metaxalone]]
* [[Methocarbamol]]


== References ==
== References ==
{{Reflist|2}}
{{Reflist}}
{{Unreferenced|date=March 2010}}



{{Anxiolytics}}
{{Anxiolytics}}
{{Muscle relaxants}}
{{Muscle relaxants}}
{{Sedatives}}


[[Category:Carbamates]]
[[Category:Carbamates]]
[[Category:Drugs with unknown mechanisms of action]]
[[Category:Oxazolidines]]
[[Category:Oxazolidines]]
[[Category:Phenol ethers]]
[[Category:Phenol ethers]]
[[Category:Methoxy compounds]]



{{musculoskeletal-drug-stub}}
{{musculoskeletal-drug-stub}}
{{nervous-system-drug-stub}}
{{sedative-stub}}

Latest revision as of 07:58, 16 August 2023

Mephenoxalone
Clinical data
Trade namesDorsiflex, Moderamin, Control-OM
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
Identifiers
  • 5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.658 Edit this at Wikidata
Chemical and physical data
FormulaC11H13NO4
Molar mass223.228 g·mol−1
3D model (JSmol)
  • O=C2OC(COc1c(OC)cccc1)CN2
  • InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13) ☒N
  • Key:ZMNSRFNUONFLSP-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Mephenoxalone (trade names Dorsiflex, Moderamin, Control-OM) is a muscle relaxant[2] and mild anxiolytic.[3] It inhibits neuron transmission, relaxing skeletal muscles by inhibiting the reflex arc.[citation needed] As the effect of muscle relaxation, mephenoxalone affects mental condition, and is also a treatment for nervousness and anxiety.

See also

[edit]

References

[edit]
  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Magnenat M (December 1961). "[The utilization in psychotherapy of a tensiolytic agent with muscle relaxant effect, Control OM (mephenoxalone), alone or associated with thymoleptics]". Therapeutische Umschau. Revue Therapeutique. 18: 516–20. PMID 14468333.
  3. ^ MIMS: Mephenoxalone
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