TIRAP: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{protein |
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{{infobox gene}} |
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|Name=toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
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'''TIRAP''' ('''TIR domain containing adaptor protein''') is an adapter molecule associated with [[toll-like receptor]]s. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates [[NF-kappa-B]], [[MAPK1]], [[MAPK3]] and [[JNK]], which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
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|image= |
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|HGNCid=17192 |
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|Symbol=TIRAP |
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|AltSymbols= |
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|EntrezGene=114609 |
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|OMIM=606252 |
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|RefSeq=NM_148910 |
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|UniProt=P58753 |
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|PDB= |
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|ECnumber= |
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|Chromosome=11 |
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|Arm=q |
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|Band=24.2 |
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|LocusSupplementaryData= |
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}} |
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'''TIRAP''' is an adapter molecule associated with [[toll-like receptor]]s. |
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[[Image:Toll-like receptor pathways revised.jpg|thumbnail|center|500px|Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations]] |
[[Image:Toll-like receptor pathways revised.jpg|thumbnail|center|500px|Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations]] |
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{{biochem-stub}} |
{{biochem-stub}} |
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{{TLR signaling pathway}} |
{{TLR signaling pathway}} |
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[[de:Tirap]] |
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[[ru:TIRAP]] |
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Latest revision as of 19:07, 9 June 2023
TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
See also
[edit]External links
[edit]- TIRAP+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
.svg){kind=small} | This biochemistry article is a stub. You can help Wikipedia by expanding it. |
- ^ a b c GRCh38: Ensembl release 89: ENSG00000150455 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032041 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.