SCN2B: Difference between revisions

SCN2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FEB, 5FDY
Identifiers
Aliases	SCN2B, ATFB14, sodium voltage-gated channel beta subunit 2
External IDs	OMIM: 601327; MGI: 106921; HomoloGene: 3373; GeneCards: SCN2B; OMA:SCN2B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,176,639 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,041,368 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; lateral nuclear group of thalamus; ; cerebellar cortex; ; cerebellar hemisphere; ; prefrontal cortex; ; right hemisphere of cerebellum; ; cerebellar vermis; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; lateral geniculate nucleus; ; olfactory tubercle; ; superior colliculus; ; medial geniculate nucleus; ; habenula; ; lateral septal nucleus; ; lateral hypothalamus; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; sodium channel regulator activity; sodium channel activity; voltage-gated sodium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; voltage-gated sodium channel complex; membrane;
Biological process	chemical synaptic transmission; nervous system development; cardiac muscle cell action potential involved in contraction; sodium ion transport; sodium ion transmembrane transport; regulation of sodium ion transmembrane transporter activity; cardiac muscle contraction; regulation of heart rate by cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; membrane depolarization during cardiac muscle cell action potential; regulation of ion transmembrane transport; ion transport; response to pyrethroid;
	Sources:Amigo / QuickGO
Orthologs
	6327
	72821
	ENSG00000149575
	ENSMUSG00000070304
	O60939
	Q56A07
	NM_004588
	NM_001014761
	NP_004579
	NP_001014761
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 00:48, 4 March 2023

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149575 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070304 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
^ "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

External links

SCN2B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: O60939 (Sodium channel subunit beta-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149575 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070304 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10198179-5] Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.

[entrez-6] "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=6327}}
+{{Infobox_gene}}
-'''Sodium channel subunit beta-2''' is a [[protein]] that in humans is encoded by the ''SCN2B'' [[gene]].<ref name="pmid10198179">{{cite journal | author = Plummer NW, Meisler MH | title = Evolution and diversity of mammalian sodium channel genes | journal = Genomics | volume = 57 | issue = 2 | pages = 323–31 | year = 1999 | month = May | pmid = 10198179 | pmc =  | doi = 10.1006/geno.1998.5735 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6327| accessdate = }}</ref>
+'''Sodium channel subunit beta-2''' is a [[protein]] that in humans is encoded by the ''SCN2B'' [[gene]].<ref name="pmid10198179">{{cite journal | vauthors = Plummer NW, Meisler MH | title = Evolution and diversity of mammalian sodium channel genes | journal = Genomics | volume = 57 | issue = 2 | pages = 323–31 |date=May 1999 | pmid = 10198179 | doi = 10.1006/geno.1998.5735 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6327}}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
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 ==See also==
@@ Line 16: / Line 11: @@
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  | vauthors=Hartshorne RP, Catterall WA |title=The sodium channel from rat brain. Purification and subunit composition. |journal=J. Biol. Chem. |volume=259 |issue= 3 |pages= 1667–75 |year= 1984 |doi=10.1016/S0021-9258(17)43460-0 |pmid= 6319405 |doi-access=free }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Adams MD, Kerlavage AR, Fleischmann RD, etal |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
-| citations =
-*{{cite journal  | author=Hartshorne RP, Catterall WA |title=The sodium channel from rat brain. Purification and subunit composition. |journal=J. Biol. Chem. |volume=259 |issue= 3 |pages= 1667–75 |year= 1984 |pmid= 6319405 |doi=  }}
+*{{cite journal   |vauthors=Isom LL, Ragsdale DS, De Jongh KS, etal |title=Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif |journal=Cell |volume=83 |issue= 3 |pages= 433–42 |year= 1996 |pmid= 8521473 |doi=10.1016/0092-8674(95)90121-3  |s2cid=13998841 |doi-access=free }}
-*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=  }}
+*{{cite journal   |vauthors=Eubanks J, Srinivasan J, Dinulos MB, etal |title=Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel |journal=NeuroReport |volume=8 |issue= 12 |pages= 2775–9 |year= 1997 |pmid= 9295116 |doi=10.1097/00001756-199708180-00025  |s2cid=21051920 }}
-*{{cite journal  | author=Isom LL, Ragsdale DS, De Jongh KS, ''et al.'' |title=Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. |journal=Cell |volume=83 |issue= 3 |pages= 433–42 |year= 1996 |pmid= 8521473 |doi=10.1016/0092-8674(95)90121-3  }}
+*{{cite journal   |vauthors=Bolino A, Seri M, Caroli F, etal |title=Exclusion of the SCN2B gene as candidate for CMT4B |journal=Eur. J. Hum. Genet. |volume=6 |issue= 6 |pages= 629–34 |year= 1999 |pmid= 9887383 |doi= 10.1038/sj.ejhg.5200220 |doi-access= free }}
-*{{cite journal  | author=Eubanks J, Srinivasan J, Dinulos MB, ''et al.'' |title=Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel. |journal=Neuroreport |volume=8 |issue= 12 |pages= 2775–9 |year= 1997 |pmid= 9295116 |doi=10.1097/00001756-199708180-00025  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Bolino A, Seri M, Caroli F, ''et al.'' |title=Exclusion of the SCN2B gene as candidate for CMT4B. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 6 |pages= 629–34 |year= 1999 |pmid= 9887383 |doi= 10.1038/sj.ejhg.5200220 }}
+*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Kim DY, Ingano LA, Carey BW, etal |title=Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 23251–61 |year= 2005 |pmid= 15833746 |doi= 10.1074/jbc.M412938200 |doi-access= free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Kim DY, Ingano LA, Carey BW, ''et al.'' |title=Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 23251–61 |year= 2005 |pmid= 15833746 |doi= 10.1074/jbc.M412938200 }}
-}}
 {{refend}}
 == External links ==
 * {{MeshName|SCN2B+protein,+human}}
+* {{PDBe-KB2|O60939|Sodium channel subunit beta-2}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Ion channels|g2}}
 [[Category:Ion channels]]
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