Picoplatin: Difference between revisions
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| ImageFile = Picoplatin.png |
| ImageFile = Picoplatin.png |
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| ImageSize = 150px |
| ImageSize = 150px |
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| IUPACName = azane; 2-methylpyridine; platinum(2+); dichloride |
| IUPACName = azane; 2-methylpyridine; platinum(2+); dichloride |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo = 181630-15-9 |
| CASNo = 181630-15-9 |
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| PubChem = 177358 |
| PubChem = 177358 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 154428 |
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| SMILES_Comment = ionic form |
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| SMILES1 = Cl[Pt-2](Cl)([NH3+])[n+]1ccccc1C |
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| SMILES1_Comment = coordination form |
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| InChI = 1/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2 |
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| InChIKey = IIMIOEBMYPRQGU-NUQVWONBAG |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C6H7N.2ClH.H3N.Pt/c1-6-4-2-3-5-7-6;;;;/h2-5H,1H3;2*1H;1H3;/q;;;;+2/p-2 |
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| StdInChIKey = IIMIOEBMYPRQGU-UHFFFAOYSA-L |
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|Section2={{Chembox Properties |
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| C=6|H=10|Cl=2|N=2|Pt=1 |
| C=6 | H=10 | Cl=2 | N=2 | Pt=1 |
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'''Picoplatin''' is a [[ |
'''Picoplatin''' is a [[platinum-based antineoplastic agent]] in clinical development by Poniard Pharmaceuticals (previously NeoRx) for the treatment of patients with solid [[tumor]]s.<ref>{{cite journal | doi = 10.1039/C0DT00292E | volume=39 | title=The status of platinum anticancer drugs in the clinic and in clinical trials | year=2010 | journal=Dalton Transactions | last1 = Wheate | first1 = Nial J.| issue=35 | pages=8113–8127 | url=https://ses.library.usyd.edu.au/bitstream/2123/9269/2/41%20Dalton%20perspective.pdf | pmid=20593091 | hdl=2123/14271 | hdl-access=free }}</ref> |
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In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone-refractory prostate cancer.<ref>[http://www.poniard.com/programs/picoplatin/clinical.html Picoplatin Clinical Results], Poniard Pharmaceuticals</ref> However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced [[small cell lung cancer]].<ref>[http://www.fiercebiotech.com/story/breaking-news-poniard-shares-crash-phiii-picoplatin-failure/2009-11-16 Poniard shares crash on Phase III picoplatin failure], fiercebiotech.com, November 16, 2009</ref> Hopes are now pinned on its use for metastatic [[colorectal cancer]]<ref>http://www.genengnews.com/specialreports/sritem.aspx?oid=69418732 Nov 2009</ref> |
In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone-refractory prostate cancer.<ref>[http://www.poniard.com/programs/picoplatin/clinical.html Picoplatin Clinical Results], Poniard Pharmaceuticals</ref> However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced [[small cell lung cancer]].<ref>[http://www.fiercebiotech.com/story/breaking-news-poniard-shares-crash-phiii-picoplatin-failure/2009-11-16 Poniard shares crash on Phase III picoplatin failure], fiercebiotech.com, November 16, 2009</ref> Hopes are now pinned on its use for metastatic [[colorectal cancer]].<ref>http://www.genengnews.com/specialreports/sritem.aspx?oid=69418732 Nov 2009</ref> |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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[[Category: |
[[Category:Platinum(II) compounds]] |
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[[Category:Organochlorides]] |
[[Category:Organochlorides]] |
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[[Category:Pyridines]] |
[[Category:Pyridines]] |
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[[Category:Platinum-based antineoplastic agents]] |
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Latest revision as of 17:10, 1 June 2022
Names | |
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IUPAC name
azane; 2-methylpyridine; platinum(2+); dichloride
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.205.233 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C6H10Cl2N2Pt | |
Molar mass | 376.14 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Picoplatin is a platinum-based antineoplastic agent in clinical development by Poniard Pharmaceuticals (previously NeoRx) for the treatment of patients with solid tumors.[1]
In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone-refractory prostate cancer.[2] However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced small cell lung cancer.[3] Hopes are now pinned on its use for metastatic colorectal cancer.[4]
References
[edit]- ^ Wheate, Nial J. (2010). "The status of platinum anticancer drugs in the clinic and in clinical trials" (PDF). Dalton Transactions. 39 (35): 8113–8127. doi:10.1039/C0DT00292E. hdl:2123/14271. PMID 20593091.
- ^ Picoplatin Clinical Results, Poniard Pharmaceuticals
- ^ Poniard shares crash on Phase III picoplatin failure, fiercebiotech.com, November 16, 2009
- ^ http://www.genengnews.com/specialreports/sritem.aspx?oid=69418732 Nov 2009