EPH receptor A1

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.

EPHA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1K, 2K1L, 3HIL, 3KKA
Identifiers
Aliases	EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDs	OMIM: 179610; MGI: 107381; HomoloGene: 3835; GeneCards: EPHA1; OMA:EPHA1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q34-q35 Start 143,390,289 bp End 143,408,856 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.1 Start 42,335,421 bp End 42,350,202 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen right uterine tube right lobe of liver minor salivary glands vagina left lobe of thyroid gland ectocervix mucosa of transverse colon right lung Top expressed in lip tail of embryo esophagus embryo epiblast female urethra right kidney ascending aorta male urethra genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding transmembrane-ephrin receptor activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding protein kinase binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane cytoplasm neuron projection receptor complex Biological process somatic stem cell population maintenance negative regulation of protein kinase activity activation of GTPase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell-matrix adhesion positive regulation of cell migration regulation of GTPase activity positive regulation of angiogenesis protein phosphorylation cell surface receptor signaling pathway negative regulation of cell migration cell adhesion angiogenesis positive regulation of cell population proliferation protein autophosphorylation peptidyl-tyrosine phosphorylation substrate adhesion-dependent cell spreading positive regulation of stress fiber assembly ephrin receptor signaling pathway negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2041 13835 Ensembl ENSG00000146904 ENSG00000284816 ENSMUSG00000029859 UniProt P21709 Q60750 RefSeq (mRNA) NM_005232 NM_023580 RefSeq (protein) NP_005223 NP_076069 Location (UCSC) Chr 7: 143.39 – 143.41 Mb Chr 6: 42.34 – 42.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
• Hirai H, Maru Y, Hagiwara K, et al. (1988). "A novel putative tyrosine kinase receptor encoded by the eph gene". Science. 238 (4834): 1717–20. doi:10.1126/science.2825356. PMID 2825356.
• Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
• Owshalimpur D, Kelley MJ (1999). "Genomic structure of the EPHA1 receptor tyrosine kinase gene". Mol. Cell. Probes. 13 (3): 169–73. doi:10.1006/mcpr.1999.0228. PMID 10369740.
• Kalo MS, Pasquale EB (October 1999). "Signal transfer by eph receptors". Cell and Tissue Research. 298 (1): 1–9. doi:10.1007/pl00008807. PMID 10502115. S2CID 1241074.
• Coulthard MG, Lickliter JD, Subanesan N, et al. (2002). "Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues". Growth Factors. 18 (4): 303–17. doi:10.3109/08977190109029118. PMID 11519828. S2CID 43039239.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.