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Kenneth B. Storey

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Kenneth B. Storey, FRSC (born October 23, 1949) is a Canadian scientist whose work draws from a variety of fields including biochemistry and molecular biology. He is currently a Professor of Biology and Chemistry at Carleton University. Storey has a world-wide reputation for his research on biochemical adaptation - the molecular mechanisms that allow animals to adapt to and endure severe environmental stresses such as deep cold, oxygen deprivation, and desiccation.[1]

Kenneth Storey
Born
Kenneth Bruce Storey

October 23, 1949
Taber, Alberta
CitizenshipCanadian
AwardsRoyal Society of Canada Fellow (1990)
ISI Highly Cited Researcher (2004-present)
Scientific career
FieldsMolecular Physiology
Biochemistry
InstitutionsCarleton University, Canada
Doctoral advisorPeter W. Hochachka

Biography

Storey is a Professor of Biochemistry, cross-appointed in the Departments of Biology, Chemistry and Neuroscience and holds the Canada Research Chair in Molecular Physiology at Carleton University in Ottawa.[2]

Storey is an elected fellow of the Royal Society of Canada.[3] and of the American Association for the Advancement of Science. He has won fellowships and awards for research excellence including the Fry medal from the Canadian Society of Zoologists (2011), the Flavelle medal from the Royal Society of Canada (2010), Ottawa Life Sciences Council Basic Research Award (1998), a Killam Senior Research Fellowship (1993–1995), the Ayerst Award from the Canadian Biochemical Society (1989), an E.W.R. Steacie Memorial Fellowship from the Natural Sciences and Engineering Research Council of Canada (1984–1986), and four Carleton University Research Achievement Awards. Storey is the author of over 600 research articles, the editor of seven books, and an organizer of numerous international symposia.[4]

Research

Storey's research includes studies of enzyme properties, gene expression, protein phosphorylation, and cellular signal transduction mechanisms to seek out the basic principles of how organisms endure and flourish under extreme conditions. He is particularly known within the field of cryobiology for his studies of animals that can survive freezing, especially the frozen "frog-sicles" (Rana sylvatica) that have made his work popular with multiple TV shows and magazines.[5][6][7] Storey's studies of the adaptations that allow frogs, insects, and other animals to survive freezing have made major advances in the understanding of how cells, tissues and organs can endure freezing.[7] Storey was also responsible for the discovery that some turtle species are freeze tolerant: newly hatched painted turtles that spend their first winter on land(Chrysemys picta marginata & C. p. bellii) and adult box turtles Terrapene carolina. These turtles are unique as they are the only reptiles, and highest vertebrate life form, known to tolerate prolonged natural freezing of extracellular body fluids during winter hibernation.[8] These advances may aid the development of organ cryopreservation technology.[2] A second area of his research is metabolic rate depression - understanding the mechanisms by which some animals can sharply reduce their metabolism and enter a state of hypometabolism or torpor that allows them to survive over the long term under difficult environmental stresses. His studies have identified molecular mechanisms that underlie metabolic arrest across phylogeny and that support phenomena including mammalian hibernation, estivation, and anoxia and ischemia tolerance. Control mechanisms include transcription factor changes that alter gene expression, and reversible phosphorylation of key metabolic enzymes by protein kinases and protein phosphatases. These studies across multiple species also hold key applications for medical science, particularly for preservation technologies that aim to extend the survival time of excised organs in cold or frozen storage.[2] Additional applications include insights into hyperglycemia in metabolic syndrome and diabetes,[9] and anoxic and ischemic damage caused by heart attack and stroke.[10]

  • Plenary & keynote lectures: 56
  • Conference scientific committees: 3
  • Invited symposium lectures: 89
  • Symposia organized: 27
  • Invited university seminars: 366
  • Voluntary communications at conferences: 376
  • Total Publications: 623
    • Refereed journal articles: 491
    • Invited articles in conference proceedings: 45
    • Invited review articles: 31
    • Book chapters: 36
    • Magazine & encyclopedia articles: 13
    • Books edited: 7

Selected publications

Books

  • Storey, K.B.; Storey, J.M., eds. (2002). Sensing, Signaling & Cell Adaptation. Cell and Molecular Responses to Stress. Vol. 3. Amsterdam: Elsevier Press.

Articles

  • Storey, J.M. (2010). "Metabolic regulation and gene expression during aestivation". In Navas, C.A.; Carvalho, J.E. (eds.). Aestivation: Molecular and Physiological Aspects. Progress in Molecular and Subcellular Biology. Vol. 49. Heidelberg: Springer. pp. 25–45. doi:10.1007/978-3-642-02421-4_2. {{cite book}}: |first1= missing |last1= (help)
  • Sugimura, T.; Hayashi, Y.; Fujii, H.; Matsumoto, T.; Masui, H.; Otsuki, Y.; Yajima, M., eds. (2009). "Animal cold hardiness". Pioneer Insects Open New Fields in Biology. Kyoto, Japan: The Kinugasa-kai Foundation. pp. 40–53. {{cite book}}: |editor5-first= missing |editor5-last= (help); |first2= missing |last2= (help); More than one of |editor1-last= and |editor-last= specified (help)CS1 maint: multiple names: authors list (link)
  • Storey, KB (2005). "Hibernating mammals: can natural cryoprotective mechanisms help prolong lifetimes of transplantable organs?". In Sames, K.; Sethe, S.; Stolzing, A. (eds.). Extending the Lifespan. Munster: LIT Verlag. pp. 219–228.
  • Storey, J.M. (2005). "Freeze tolerance". In Gerday, C.; Glansdorff, N. (eds.). Extremophiles. Encyclopedia of Life Support Systems (EOLSS). Oxford, UK: Eolss Publishers. {{cite book}}: |first1= missing |last1= (help)
  • Storey, J.M. (2004). "Oxygen limitation and metabolic rate depression". In Storey, K.B. (ed.). Functional Metabolism: Regulation and Adaptation. Hoboken, NJ: Wiley-Liss. pp. 415–442. {{cite book}}: |first1= missing |last1= (help)
  • Storey, J.M. (2004). "Physiology, biochemistry and molecular biology of vertebrate freeze tolerance: the wood frog". In Benson, E.; Fuller, B.; Lane, N. (eds.). Life in the Frozen State. Boca Raton: CRC Press. pp. 243–274. {{cite book}}: |first1= missing |last1= (help)
  • Storey, K.B. (2002). "Natural hypothermic preservation: the mammalian hibernator". Cell Preservation Technology. 1: 3–16. doi:10.1089/15383440260073257.

Boards

  • Journal of Thermal Biology (since 2007)
  • Journal of Comparative Physiology B (since 1994)
  • Past member: American Journal of Physiology, Molecular Physiology, Copeia, J. Experimental Zoology,Environmental Reviews, Biochemistry & Cell Biology, Cryo-Letters, Experimental Biology Online

Professional Positions

  • Canada Research Chair (Tier 1) in Molecular Physiology, College of Natural Sciences, Carleton University, Ottawa (7/01 - present)[2]
  • Professor of Biochemistry, Departments of Biology and Chemistry, Carleton University, Ottawa (7/89 -present)
  • Professor of Biochemistry and Biology, Carleton University, Ottawa (7/85-6/89)
  • Associate Professor of Biochemistry and Biology, Carleton University, Ottawa (7/79-6/85)
  • Assistant Professor of Zoology, Duke University, Durham, North Carolina (7/74-6/79)

Professional Honours

  • Fry Award - Canadian Society of Zoologists (2011)
  • Flavelle Medal of the Royal Society of Canada (2010)
  • Graduate mentor award - Carleton University (inaugural 2010)
  • Carleton University Research Achievement Award (2008, 2003, 1998, 1992 and 1989)
  • Distinguished Alumni Award, University of Calgary (2007)
  • Professor Extraordinary, Botany & Zoology, Stellenbosch University, S. Africa (2005–2007)
  • ISI Highly Cited Researcher (2004–present)
  • Public Awareness Prize, Canadian Society of Zoologists (2000)
  • Ottawa Life Sciences Council, Basic Research Award (1998)
  • Fellow of the American Association for the Advancement of Science, elected (1997)
  • Killam Senior Research Fellowship (1993–1995)
  • Fellow of the Royal Society of Canada, elected (1990)[3]
  • Ayerst Award, Canadian Biochemical Society (1989)
  • E.W.R. Steacie Memorial Fellowship, NSERC Canada (1984–1986)

References

  1. ^ "Kenneth Storey Bio". Ask the Scientists. PBS.
  2. ^ a b c d "How research in Ottawa can preserve organs for transplant in the future" (PDF). Carleton University.
  3. ^ a b "Royal Society of Canada members at Carleton University". Carleton University.
  4. ^ Cummings, Laura. "Carleton Professor Not So Coldhearted". Research Success Stories. Carleton University. {{cite web}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  5. ^ McIlroy, Anne (3 December 2009). "Frozen frogs thaw out and hop away". The Globe and Mail. Retrieved 15 January 2010.
  6. ^ "Melted Frogsicle" (Silverlight video). Discovery Channel.
  7. ^ a b "Freeze and thaw frogs" (Silverlight video). Discovery Channel.
  8. ^ Storey, KB; Storey, JM; Brooks, SP; Churchill, TA; Brooks, RJ (1988). "Hatchling turtles survive freezing during winter hibernation". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8350–4. PMC 282428. PMID 3186730.
  9. ^ http://sandrablakeslee.com/articles/ice_age_diabetes_may05.php
  10. ^ http://health.usnews.com/usnews/health/articles/050523/23hibernate.htm

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