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Clarified the contribution of Bruno Ceccarelli and his group to the origin of the hypothesis and the definition of the term kiss-and-run. Introduced the groundbreaking work by Alvarez de Toledo who directly demonstrated "kiss-and-run" before the term was even invented. Introduced appropriate citations |
m corrected "memebrane" |
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}}</ref><ref name="Fesce">{{cite journal|last1=Fesce|first1=R|last2=Grohovaz|first2=F|last3=Valtorta|first3=F|last4=Meldolesi|first4=J|title=Neurotransmitter release: fusion or 'kiss-and-run'?|journal=Trends in Cell Biology|date=1994|volume=4|issue=1|page=1|pages=4|pmid=14731821|url=https://www.ncbi.nlm.nih.gov/pubmed/14731821}}</ref>.
Kiss-and-run differs from full fusion, where the vesicle collapses fully into the [[plasma membrane]] and is then later retrieved by a [[clathrin]]-coat-dependent process.<ref>{{cite journal|last1=Heuser|first1=JE|last2=Reese|first2=TS|title=Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction.|journal=J.Cell Biol.|date=1973|volume=57|issue=2|pages=315-344|pmid=4348786|url=https://www.ncbi.nlm.nih.gov/pubmed/4348786}}</ref> The idea that neurotransmitter might be released in "quanta" by the transient fusion of snaptic vesicles with the presynaptic membrane was first introduced by [[Bernard Katz]] and Jose del Castillo in 1955, when the first EM images of nerve terminals first appeared. The possibility of transient fusion and rapid retrieval of vesicle
Today, there is back and forth debate over full fusion and kiss-and-run fusion and which model portrays a more accurate picture of the mechanisms behind synaptic release<ref>{{Cite journal
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