Phenylethanolamine N-methyltransferase: Difference between revisions

Two potent PNMT inhibitors (LY134046 and LY78335) were long lasting antagonists of both ethanol intoxication and sedation. This suggests a central role that PNMT and epinephrine play in the synthesis of [[ethanol]] and [[pentobarbital]] induced sedation and intoxication.<ref>{{cite journal|last1=Mefford|first1=IN|last2=Lister|first2=RG|last3=Ota|first3=M|last4=Linnoila|first4=M|title=Antagonism of ethanol intoxication in rats by inhibitors of phenylethanolamine N-methyltransferase.|journal=Alcoholism,: clinicalClinical and experimentalExperimental researchResearch|date=February 1990|volume=14|issue=1|pages=53–7|pmid=2178473|doi=10.1111/j.1530-0277.1990.tb00446.x}}</ref>