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One study using [[positron emission tomography]] (PET) scans found that areas controlling speech in the left hemisphere were "reactivated" by the end of Melodic Intonation Therapy (Belin et al., 1996), in 7 patients. Further work suggests that MIT can result in significant changes in brain structure through the brain's own [[neuroplasticity]]. Right-hemisphere [[axon]] connections in 6 patients were found to be increased in volume after MIT. At least theoretically, this could allow for language processing in right homologous areas, suggesting that the right hemisphere may compensate for an impaired left hemisphere by taking up language processing responsibilities (Schlaug et al., 2009). Some evidence suggests that the positive effects of MIT can be enhanced with non-invasive brain stimulation [http://www.frontiersin.org/Auditory_Cognitive_Neuroscience/10.3389/fpsyg.2011.00230/full (Vines et al., 2011]). During MIT training sessions, the researchers applied anodal [[transcranial direct current stimulation]] (tDCS) over the equivalent of Broca's area in the right hemisphere of 6 stroke patients with [[non-fluent aphasia]]. Compared to sham stimulation, the anodal stimulation led to a significant improvement in fluency.
However, a recent study suggests that it may not be singing itself that facilitates speech production in patients with [[non-fluent aphasia]] and [[apraxia of speech]], but [[rhythm| rhythmic pacing]] and lyric type [http://brain.oxfordjournals.org/content/134/10/3083.full.pdf (Stahl et al., 2011]). The rates of correct syllable production were found to be similar when patients were singing or speaking rhythmically. Hence, the study did not reveal an effect of singing over rhythmic speech. Also, the results indicate that speech production in patients with left-hemisphere [[basal ganglia]] [[lesions]] may be particularly dependent on external rhythmic cues, such as a metronome. Patients with larger basal ganglia lesions produced more syllables correctly when they were singing or speaking with rhythmic accompaniment. Finally, the results
The critical role of [[rhythm|rhythmic pacing]] and [[formulaic speech|formulaic language]] in MIT was confirmed in a subsequent therapy study [http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00035/full (Stahl et al., 2013]). The results of the study suggest that singing and rhythmic speech may be similarly effective in the treatment of non-fluent aphasia and apraxia of speech. These findings challenge the view that singing causes a transfer of language function from the left to the right hemisphere. Instead, patients made good progress in the production of [[formulaic speech|formulaic expressions]], known to be supported by areas of the right hemisphere. Therefore, the particular sensitivity of the right hemisphere to MIT may,
== Who Benefits from Melodic Intonation Therapy ==
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