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'''Secondary''' or '''peripheral lymphoid organs''' maintain mature naive lymphocytes and initiate an adaptive immune response. The peripheral lymphoid organs are the sites of lymphocyte activation by antigen. Activation leads to clonal expansion and affinity maturation. Mature lymphocytes recirculate between the blood and the peripheral lymphoid organs until they encounter their specific antigen.
Secondary lymphoid tissue provides the environment for the foreign or altered native molecules ([[antigen]]s) to interact with the lymphocytes. It is exemplified by the [[lymph node]]s, and the lymphoid follicles in [[tonsil]]s, [[Peyer's patch]]es, [[spleen]], [[adenoid]]s, [[skin]], etc. that are associated with the [[mucosa-associated lymphoid tissue]] (
==== Lymph nodes ====
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