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His research is focused on the fasting-mimicking diet (FMD). The FMD is a low-calorie, low-protein, moderate-carbohydrate, moderate-fat [[plant-based diet]] program, that he argues mimics the effects of periodic [[fasting]] or [[water fasting]]. The course lasts five days, while still aiming to provide the body with nutrition,<ref name="ScienceDaily0217">{{cite news|url=https://www.sciencedaily.com/releases/2017/02/170216103923.htm|title=Scientifically-designed fasting diet lowers risks for major diseases|date=February 16, 2017|publisher=ScienceDaily|last1=University of Southern California|access-date=June 6, 2017|archive-date=August 28, 2018|archive-url=https://web.archive.org/web/20180828192200/https://www.sciencedaily.com/releases/2017/02/170216103923.htm|url-status=live}}</ref><ref name="ABCKing2017">{{cite news|url=http://www.abc.net.au/news/2015-06-19/fasting-diets-and-longer-life-may-go-hand-in-hand/6559636|title=Fasting diets and longer life may go hand-in-hand, new research finds|date=June 19, 2015|publisher=ABC|agency=ABC Health|last1=King|first1=Jennifer|access-date=June 6, 2017|archive-date=February 18, 2018|archive-url=https://web.archive.org/web/20180218102802/http://www.abc.net.au/news/2015-06-19/fasting-diets-and-longer-life-may-go-hand-in-hand/6559636|url-status=live}}</ref> and is considered a periodic fast.<ref name="WSJ0417">{{cite news|url=https://www.wsj.com/articles/can-different-forms-of-fasting-make-you-healthier-1491962461|title=Can Different Forms of Fasting Make You Healthier?|date=April 11, 2017|publisher=Dow Jones & Company|agency=Wall Street Journal|ref=WSJLandro0417|last1=Landro|first1=Laura|access-date=June 6, 2017|archive-date=September 11, 2018|archive-url=https://web.archive.org/web/20180911172324/https://www.wsj.com/articles/can-different-forms-of-fasting-make-you-healthier-1491962461|url-status=live
Longo "founded the L-Nutra technology company and developed the ProLon fasting-mimicking diet."<ref>[https://health.usnews.com/wellness/food/articles/what-is-the-fasting-mimicking-diet Fasting-Mimicking Diet: A DIY Meal Plan]</ref>
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