Gender-affirming hormone therapy: Difference between revisions

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Unlike feminizing hormone therapy, individuals undergoing masculinizing hormone therapy do not usually require additional hormone suppression such as estrogen suppression. Therapeutic doses of testosterone are usually sufficient to inhibit the production of estrogen to desired physiologic levels.<ref name="Bangalore_Krishna_2019" />
 
The desired effects of masculinizing hormone therapy focus on the development of masculine [[secondary sex characteristic]]s. These desired effects include: increased muscle mass, increased bone turnover,<ref>{{Cite journal |last1=Van Caenegem |first1=E |last2=Wierckx |first2=K |last3=Taes |first3=Y |last4=Schreiner |first4=T |last5=Vandewalle |first5=S |last6=Toye |first6=K |last7=Lapauw |first7=B |last8=Kaufman |first8=J-M |last9=T'Sjoen |first9=G |date=February 2015 |title=Body composition, bone turnover, and bone mass in trans men during testosterone treatment: 1-year follow-up data from a prospective case–controlled study (ENIGI) |url=https://academic.oup.com/ejendo/article-abstract/172/2/163/6660907?redirectedFrom=fulltext |journal=European Journal of Endocrinology |volume=172 |issue=2 |pages=163–171 |doi=10.1530/eje-14-0586 |pmid=25550352 |issn=0804-4643}}</ref> development of facial hair, voice deepening, increase and thickening of body hair, and more.<ref>{{Cite web | vauthors = Deutsch MB | date = 17 June 2016 | title = Overview of masculinizing hormone therapy | work = UCSF Gender Affirming Health Program | url = https://transcare.ucsf.edu/guidelines/masculinizing-therapy | access-date = 2021-11-12 | location = San Francisco, CA | publisher = The University of California | archive-date = 2023-06-19 | archive-url = https://web.archive.org/web/20230619070340/https://transcare.ucsf.edu/guidelines/masculinizing-therapy | url-status = live }}</ref>
{| class="wikitable"
|+Effects of masculinizing hormone therapy<ref name="UCSF_Transgender_Care" /><ref name="ColemanBockting2012" />
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==Safety==
Hormone therapy for transgender individuals has been shown in medical literature to be generally safe, when supervised by a qualified medical professional.<ref>{{cite journal | vauthors = Weinand JD, Safer JD | title = Hormone therapy in transgender adults is safe with provider supervision; A review of hormone therapy sequelae for transgender individuals | journal = Journal of Clinical & Translational Endocrinology | volume = 2 | issue = 2 | pages = 55–60 | date = June 2015 | pmid = 28090436 | pmc = 5226129 | doi = 10.1016/j.jcte.2015.02.003 }}</ref> There are potential risks with hormone treatment that will be monitored through screenings and lab tests such as blood count (hemoglobin), kidney and liver function, blood sugar, potassium, and cholesterol.<ref name="Transgender_Care_Testosterone" /><ref name="Transgender_Care_Estrogen" /> Taking more medication than directed may lead to health problems such as increased risk of cancer, heart attack from thickening of the blood, blood clots, and elevated cholesterol.<ref name="Transgender_Care_Testosterone" /><ref>{{cite journal | vauthors = | title = A randomized, double-blind study of two combined oral contraceptives containing the same progestogen, but different estrogens. World Health Organization Task Force on Oral Contraception | journal = Contraception | volume = 21 | issue = 5 | pages = 445–459 | date = May 1980 | pmid = 7428356 | doi = 10.1016/0010-7824(80)90010-4 }}</ref>Hormone therapy has been shown to improve the psychosocial well-being among transgender individuals. It's been seen to lower levels of distress in transgender individuals. <ref>{{Cite journal |lastlast1=Doyle |firstfirst1=David Matthew |last2=Lewis |first2=Tom O. G. |last3=Barreto |first3=Manuela |date=August 2023 |title=A systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender people |url=https://www.nature.com/articles/s41562-023-01605-w |journal=Nature Human Behaviour |language=en |volume=7 |issue=8 |pages=1320–1331 |doi=10.1038/s41562-023-01605-w |pmid=37217739 |issn=2397-3374|pmc=10444622 }}</ref>
 
=== Feminizing hormone therapy ===
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A study presented at ENDO 2019 (the [[Endocrine Society]]'s conference) shows that even after one year of treatment with testosterone, a [[transgender]] man can preserve his fertility potential.<ref>{{Cite web |title=Ovary function is preserved in transgender men at one year of testosterone therapy |work=Endocrine Society |url=https://www.endocrine.org/news-and-advocacy/news-room/2019/endo-2019--ovary-function-is-preserved-in-transgender-men-at-one-year-of-testosterone-therapy |access-date=25 March 2019 |date=23 March 2019 |archive-date=22 May 2022 |archive-url=https://web.archive.org/web/20220522015341/https://www.endocrine.org/news-and-advocacy/news-room/2019/endo-2019--ovary-function-is-preserved-in-transgender-men-at-one-year-of-testosterone-therapy |url-status=live }}</ref>
 
===FakeCounterfeit products===
Some online scammers have been targeting trans consumers with products that do not contain any hormones or contain ones that are opposite of what is advertised. This can happen when legislations outlaw or restrict access to treatments by legitimate medical professionals.<ref>{{cite news |last1=Xiang |first1=Chloe |title=A Sketchy Website Advertised Fake Hormone Pills to Trans People. Then, It Disappeared. |url=https://www.vice.com/en/article/z3mm88/a-sketchy-website-advertised-fake-hormone-pills-to-trans-people-then-it-disappeared |work=Vice |date=14 June 2023 |language=en |access-date=2 June 2024 |archive-date=25 July 2024 |archive-url=https://web.archive.org/web/20240725032506/https://www.vice.com/en/article/z3mm88/a-sketchy-website-advertised-fake-hormone-pills-to-trans-people-then-it-disappeared |url-status=live }}</ref>
 
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* [[Real-life experience (transgender)]]
* [[Hormone replacement therapy]]
* [[Feminizing hormone therapy]]
 
== References ==
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[[Category:Endocrine procedures]]
[[Category:Gender transition and medicine]]
[[Category:Medical treatments]]