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Researched conducted at [[Yale School of Medicine]] published in BMJ Open Gastroenterology in 2017 demonstrated improvement for those with [[irritable bowel syndrome]]<ref name = "Ali_2017">{{cite journal | vauthors = Ali A, Weiss TR, McKee D, Scherban A, Khan S, Fields MR, Apollo D, Mehal WZ | display-authors = 6 | title = Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial | journal = BMJ Open Gastroenterology | volume = 4 | issue = 1 | pages = e000164 | date = 2017-09-01 | pmid = 29018540 | pmc = 5628288 | doi = 10.1136/bmjgast-2017-000164 }}</ref>
<blockquote>"These findings reject the null hypothesis and show that a diet guided by leucocyte activation testing results in demonstrable clinical improvement in IBS. These clinical results, associated with a reduction in plasma neutrophil elastase, have implications for better understanding the role of food intolerance and the pathophysiology of IBS."<ref name = "Ali_2017" /></blockquote>
▲The '''ALCAT test''', or '''antigen leukocyte antibody test''', is one that claims to measure adverse reactions to dietary substances. It was created by American Medical Testing Laboratories and is now marketed by Cell Science Systems (also known as ALCAT Diagnostic Systems) of [[Deerfield Beach, Florida]].
A study conducted in 2014 demonstrated reactions identified as "severe" were associated with the up-regulation of [[Integrin alpha M|CD11b]] on [[CD4+ T cells and antitumor immunity|CD4]]+ and [[Cytotoxic T cell|CD8+ T cells]], suggesting a basis for further research into the mechanisms alleged.<ref>{{Cite web |url=https://www.researchgate.net/publication/262146351 |title=Food reactivity on the ALCAT leukocyte activation test is associated with upregulation of CD11b on T cells |website=ResearchGate |access-date=2017-11-22}}</ref>
The test is not supported by research and is not considered to be a reliable medical diagnostic tool; since it has not been appropriately [[Validation (drug manufacture)|validated]] it is not a suitable guide for therapeutic decisions.<ref name="pmid16047707">{{cite journal |author =Wüthrich B |title=Unproven techniques in allergy diagnosis |journal=J Investig Allergol Clin Immunol |volume=15 |issue=2 |pages=86–90 |year=2005 |pmid=16047707 |url=http://www.jiaci.org/issues/vol15issue02/1.pdf |format=pdf}}</ref><ref name="pmid20200768">{{cite journal |journal=Singapore Med J |date=January 2010 |volume=51 |issue=1 |pages=4–9 |title=Diagnostic tests for food allergy |vauthors =Gerez IF, Shek LP, Chng HH, Lee BW |pmid=20200768 |url=http://smj.sma.org.sg/5101/5101ra1.pdf}}</ref><ref name="pmid16097911">{{cite journal |journal=Med J Aust |year=2005 |volume=183 |issue=4 |pages=173–4 |author =Mullins Raymond J |author2 =Heddle Robert J |author3 =Smith Pete |title=Non-conventional approaches to allergy testing: reconciling patient autonomy with medical practitioners’ concerns |url=http://www.mja.com.au/public/issues/183_04_150805/mul10358_fm.html|quote=|pmid=16097911}}</ref><ref name="pmid9538667">{{cite journal | author=(none listed) | title=Ocena testu cytotoksyczności pokarmów (cytotoxic food test) i testu ALCAT | trans_title=Evaluation of the cytotoxic food test and the ALCAT (antigen leukocyte cellular antibody test) | journal=Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego |issn=1426-9686 | year= 1997 | volume= 2 | issue= 8 | pages= 154–9 | pmid=9538667 | doi= }}</ref><ref name="pmid14653218">{{cite journal| vauthors=Yasuhara A, Yamazaki D| title=The method of utilizing food allergy test. | journal=Rinsho Byori | year= 2003 | volume= Suppl 127 | issue= | pages= 73–8 | pmid=14653218 | doi= }}</ref><ref name="pmid19052505">{{cite journal| author=Ito K| title=Practical diagnosis of food allergy. | journal=Arerugi | year= 2008 | volume= 57 | issue= 11 | pages= 1109–16 | pmid=19052505 | doi= | pmc= }}</ref> In a position statement, the [[Australasian Society of Clinical Immunology and Allergy]] classified the ALCAT with other forms of cytotoxic tests as [[inappropriate test]]s, saying of them<blockquote>"These results have been shown to not be reproducible, give different results when duplicate samples are analysed blindly, don't correlate with those from conventional testing, and 'diagnose' food hypersensitivity in subjects with conditions where food allergy is not considered to play a pathogenic role."<ref>{{cite web|url=http://www.allergy.org.au/health-professionals/papers/unorthodox-techniques-for-diagnosis-and-treatment#s4|publisher=Australasian Society of Clinical Immunology and Allergy|title=Unorthodox Techniques for the Diagnosis and Treatment of allergy, Asthma and Immune Disorders|accessdate=2012-10-09|date=November 2007}}</ref></blockquote>▼
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==References==▼
▲== References ==
{{reflist|2}}
== External links ==
*[http://www.alcat.com/ ALCAT official website]
*[http://www.webmd.com/allergies/guide/foods-allergy-intolerance Food allergy vs. intolerance] (WebMD)
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