FAT4: Difference between revisions

'''Protocadherin Fat 4''', also known as '''cadherin family member 14''' (CDHF14) or '''FAT tumor suppressor homolog 4''' (FAT4), is a [[protein]] that in humans is encoded by the ''FAT4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79633| accessdate = }}</ref><ref name="pmid15003449">{{cite journal | author vauthors= Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y | title = Identification of new human cadherin genes using a combination of protein motif search and gene finding methods | journal = J. Mol. Biol. | volume = 337 | issue = 2 | pages = 307–17 |date=March 2004 | pmid = 15003449 | doi = 10.1016/j.jmb.2004.01.026 | url = | issn = }}</ref>

FAT4 is associated with the [[Hippo signaling pathway]].<ref name="pmid19048595">{{cite journal |authorvauthors=Qi C, Zhu YT, Hu L, Zhu YJ |title=Identification of Fat4 as a candidate tumor suppressor gene in breast cancers |journal=Int. J. Cancer |volume=124 |issue=4 |pages=793–8 |date=February 2009 |pmid=19048595 |pmc=2667156 |doi=10.1002/ijc.23775 |url=}}</ref>

Mutations in FAT4 are associated to {{SWL|type=mutations_associated_to|target=[[Hennekam syndrome|label=Hennekam syndrome}}]].<ref>{{Cite journal

| author1last1 = Alders

| issue = 9
| pages=1161–1167

*{{cite journal |authorvauthors=Katoh Y, Katoh M |title=Comparative integromics on FAT1, FAT2, FAT3 and FAT4. |journal=Int. J. Mol. Med. |volume=18 |issue= 3 |pages= 523–8 |year= 2006 |pmid= 16865240 |doi= 10.3892/ijmm.18.3.523|doi-access=free }}

*{{cite journal |authorvauthors=Caporaso N, Gu F, Chatterjee N |title=Genome-wide and candidate gene association study of cigarette smoking behaviors. |journal=PLoSPLOS ONE |volume=4 |issue= 2 |pages= e4653 |year= 2009 |pmid= 19247474 |doi= 10.1371/journal.pone.0004653 |editor1-last=Reitsma |editor1-first=Pieter H. |pmc=2644817 |bibcode=2009PLoSO...4.4653C |display-authors=etal|doi-access=free }}

*{{cite journal |authorvauthors=Liu Y, Blackwood DH, Caesar S |title=Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder |journal=Molecular Psychiatry |volume= 16|issue= 1|pages= HASH(0x11aa390)2–4 |year= 2010 |pmid= 20351715 |doi= 10.1038/mp.2009.107 |display-authors=etal|pmc=3883627}}

*{{cite journal |authorvauthors=Need AC, Attix DK, McEvoy JM |title=A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB |journal=Hum. Mol. Genet. |volume=18 |issue= 23 |pages= 4650–61 |year= 2009 |pmid= 19734545 |doi= 10.1093/hmg/ddp413 |pmc=2773267 |display-authors=etal}}

*{{cite journal |authorvauthors=Rose JE, Behm FM, Drgon T |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue= 7–8 |pages= 247–53 |year= 2010|pmid= 20379614 |doi= 10.2119/molmed.2009.00159 |pmc=2896464|display-authors=etal}}

*{{cite journal |authorvauthors=Ballif BA, VillénVillén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2004 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal|doi-access=free }}

*{{cite journal |authorvauthors=Johnson AD, Kavousi M, Smith AV |title=Genome-wide association meta-analysis for total serum bilirubin levels |journal=Hum. Mol. Genet. |volume=18 |issue= 14 |pages= 2700–10 |year= 2009 |pmid= 19414484 |doi= 10.1093/hmg/ddp202 |pmc=2701336|display-authors=etal}}

*{{cite journal |authorvauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}