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- posterNovember 2014
Detecting Phosphorylation Determined Active Protein Interaction Network during Cancer Development by Robust Network Component Analysis
DTMBIO '14: Proceedings of the ACM 8th International Workshop on Data and Text Mining in BioinformaticsPage 49https://doi.org/10.1145/2665970.2665991Motivation: In recent disease study, many key pathogen genes/proteins are found to have not significant differential expressions, and thus, they tend to be disregarded in conventional differential expression analysis or network analysis. Meanwhile, the ...
- articleNovember 2013
Reconstruction of Transcriptional Regulatory Networks by Stability-Based Network Component Analysis
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), Volume 10, Issue 6Pages 1347–1358https://doi.org/10.1109/TCBB.2012.146Reliable inference of transcription regulatory networks is a challenging task in computational biology. Network component analysis (NCA) has become a powerful scheme to uncover regulatory networks behind complex biological processes. However, the ...
- tutorialSeptember 2013
Reconstructing transcriptional regulatory networks by probabilistic network component analysis
BCB'13: Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical InformaticsPages 96–105https://doi.org/10.1145/2506583.2506599Despite encouraging progress made by integrating multi-platform data for regulatory network reconstruction, identification of transcriptional regulatory networks remains challenging due to imperfection in current biotechnology and complexity of ...
- articleSeptember 2012
Noniterative Convex Optimization Methods for Network Component Analysis
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), Volume 9, Issue 5Pages 1472–1481https://doi.org/10.1109/TCBB.2012.81This work studies the reconstruction of gene regulatory networks by the means of network component analysis (NCA). We will expound a family of convex optimization-based methods for estimating the transcription factor control strengths and the ...
- ArticleMay 2012
Reconstruction of transcription regulatory networks by stability-based network component analysis
ISBRA'12: Proceedings of the 8th international conference on Bioinformatics Research and ApplicationsPages 36–47https://doi.org/10.1007/978-3-642-30191-9_4Reliable inference of transcription regulatory networks is still a challenging task in the field of computational biology. Network component analysis (NCA) has become a powerful scheme to uncover the networks behind complex biological processes, ...
- ArticleDecember 2010
Identification of Transcriptional Regulatory Networks by Learning the Marginal Function of Outlier Sum Statistic
ICMLA '10: Proceedings of the 2010 Ninth International Conference on Machine Learning and ApplicationsPages 281–286https://doi.org/10.1109/ICMLA.2010.48Network component analysis (NCA) and other methods based on the NCA model have become powerful bioinformatics tools to reconstruct underlying regulatory networks and recover hidden biological processes. However, due to the existence of experimental ...
- ArticleSeptember 2009
An Efficient Convex Nonnegative Network Component Analysis for Gene Regulatory Network Reconstruction
PRIB '09: Proceedings of the 4th IAPR International Conference on Pattern Recognition in BioinformaticsPages 56–66https://doi.org/10.1007/978-3-642-04031-3_6A systems biology problem of reconstructing gene regulatory network from time-course gene expression microarray data via network component analysis (NCA) is investigated in this paper. Inspired by the idea that each column of the connectivity matrix can ...
- ArticleJune 2009
An Integrative Tool for Gene Regulatory Network Reconstruction Based on Microarray Data
BIBE '09: Proceedings of the 2009 Ninth IEEE International Conference on Bioinformatics and BioengineeringPages 467–470https://doi.org/10.1109/BIBE.2009.44The transcriptional regulation of gene expression has been known to be a key mechanism in the functioning of the cell and the gene expression is influenced by the transcriptional regulatory strengths. In this paper we extend the function of a former ...
- ArticleMay 2008
Integrative network component analysis for regulatory network reconstruction
ISBRA'08: Proceedings of the 4th international conference on Bioinformatics research and applicationsPages 196–207Network Component Analysis (NCA) has shown its effectiveness inregulator identification by inferring the transcription factor activity (TFA) whenboth microarray data and ChIP-on-chip data are available. However, the NCAscheme is not applicable to many ...
