RNASE1

RNASE1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DZA, 1E21, 1H8X, 1Z7X, 2E0J, 2E0L, 2E0M, 2E0O, 2K11, 2Q4G, 3F8G, 4KXH
Dynodwyr
Cyfenwau	RNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic
Dynodwyr allanol	OMIM: 180440 HomoloGene: 7919 GeneCards: RNASE1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nuclease activity; • GO:0001948, GO:0016582 protein binding; • hydrolase activity; • ribonuclease A activity; • nucleic acid binding; • endonuclease activity; • ribonuclease activity; • lyase activity;
Cydrannau o'r gell	• extracellular region; • extracellular exosome;
Prosesau biolegol	• RNA phosphodiester bond hydrolysis, endonucleolytic; • defense response to virus; • RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologau
	6035
	n/a
	ENSG00000129538
	n/a
	P07998
	n/a
	NM_198235; NM_002933; NM_198232; NM_198234
	n/a
	NP_002924; NP_937875; NP_937877; NP_937878
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Ni chefnogir y fersiwn argraffadwy bellach ac efallai y bydd gwallau rendro. Diweddarwch eich nodau tudalen a defnyddiwch y nodweddion argraffu arferol yn eich porwr.

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNASE1 yw RNASE1 a elwir hefyd yn Ribonuclease A family member 1, pancreatic (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNASE1.

RAC1
RIB1
RNS1

Llyfryddiaeth

"Functional role of glutamine 28 and arginine 39 in double stranded RNA cleavage by human pancreatic ribonuclease. ". PLoS One. 2011. PMID 21408145.
"The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity. ". Invest New Drugs. 2011. PMID 20352290.
"Increased N-glycosylation of Asnâ¸â¸ in serum pancreatic ribonuclease 1 is a novel diagnostic marker for pancreatic cancer. ". Sci Rep. 2014. PMID 25336120.
"Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase. ". Acta Crystallogr D Biol Crystallogr. 2013. PMID 24100329.
"Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.". Biophys J. 2011. PMID 21767499.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RNASE1 - Cronfa NCBI

[1]

[2]